Sulfate-Reducing Bacteria Colonize Pouches Formed for Ulcerative Colitis but Not for Familial Adenomatous Polyposis

Abstract

Sulfate-reducing bacteria are exclusive to patients with a background of ulcerative colitis. Not all ulcerative colitis pouches harbor sulfate-reducing bacteria because two ulcerative colitis pouches in this study were free of the latter. They are not present in familial adenomatous polyposis pouches or in ileostomy effluent collected from patients with ulcerative colitis. Total bacterial counts increase in ulcerative colitis pouches after stoma closure. Levels of Lactobacilli, Bifidobacterium, Bacteroides sp, Clostridium perfringens, enterococci, and coliforms were similar in both pouch groups. Because sulfate-reducing bacteria are specific to ulcerative colitis pouches, they may play a role in the pathogenesis of pouchitis.

Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India

“…Earlier reports indicate higher levels of breath methane in UC and colonic polyposis patients than in controls and detected higher rates of methanogenic bacteria from fecal specimens of patients than from those of controls (12,25). That there were higher numbers of SRB and higher rates of sulfidogenesis in UC patients than in controls supported our findings (4,5). The colonic mucosa colonized by SRB and showing simultaneous production of H 2 S has the potential to cause colonic injury in UC patients (13,19).…”

The Modern View of the Pathogenesis and Laboratory Diagnostics of Ulcerative Colitis (Literature Review)

“…Бактероиды вульгатус (Bacteroides vulgatus) входят в состав микрофлоры толстой кишки здорового че-ловека, при ВЗК обнаруживаются в повышенной концентрации и выделяют ферменты, расщепляю-щие муцин [19]. Дисбаланс микрофлоры приводит к повышенной продукции бактериями сероводо-рода, блокирующего метаболизм короткоцепочеч-ных жирных кислот в эпителии толстой кишки, что приводит к энергетическому голоданию эпителия и является одним из важных аспектов патогене-за ЯК [17,18,42].…”

The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis

“…As a supplemental control group, three patients (two men, one woman, median age 47 years, range [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] with UC and active pouchitis at inclusion were kept on antibiotics for the whole 12-week study period and biopsies were taken as for the main study group.…”