Sub-acute oral toxicity and in vivo antioxidant properties of Oxalis cernua

Belghoul, Meriama; Baghiani, Abderrahmane; Khennouf, Seddik; Arrar, Lekhmici

doi:10.1016/j.sajb.2020.07.004

Cited by 3 publications

(2 citation statements)

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“…Belghoul et al (2020) reported that the medium lethal dose (LD50) value of V. tuberculatum was higher than 2000 mg/kg bw. [16] Similarly, Manzoor Ullah et al (2022) reported that up to 2 g/kg of VA extract can be considered safe because of its LD50 value of more than 2 g/kg. [17] The results of toxicity studies indicate that VA plant extract can be classified under category 5 of the Globally Harmonized System of Classification and Labeling of Chemicals (UN 2011).…”

Section: Introductionmentioning

confidence: 99%

“…[9] Viscum album L. (VA) (Loranthaceae), known as mistletoe, is an ever green semi-parasitic plant, growing on various trees. Belghoul et al (2020) reported that the medium lethal dose (LD50) value of V. tuberculatum was higher than 2000 mg/kg bw. [16] Similarly, Manzoor Ullah et al (2022) reported that up to 2 g/kg of VA extract can be considered safe because of its LD50 value of more than 2 g/kg.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Antioxidant Activities of Viscum album L.: First Report on Interaction of Phenolics with Survivin Protein using in silico Analysis

et al. 2023

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Mistletoe, Viscum album L., (VA) known as “Ökse Otu” in Turkey, is a hemiparasitic shrub that grows especially on the trunks and crowns of broadleaf trees. This study is aimed to determination of the VA’s antioxidant compounds and evaluate their in vitro activities growing on twelve different host trees and determination of in silico approach of compounds against survivin protein. At the same time, the active ingredients determined in HPLC analysis, were performed with molecular docking and molecular dynamics analysis on survivin protein, an apoptosis inhibitor protein in cancer. Antioxidant activities of methanolic extracts of organs of VA were determined. Phytochemical properties of different organs of VA samples taken from different hosts varied as well. Total phenolic content was determined at the highest rate in fruits, followed by leaves and branches, respectively. Total flavonoid content was determined in the highest amounts in the leaves, followed by branches and fruits, respectively. Antioxidant activity values were evaluated with DPPH (using DPPH as a radical), ABTS (using ABTS as radical cation) and FRP tests. The antioxidant activity of the branches of the plant was determined at the highest rate, followed by leaves and fruits, respectively. During in silico analysis, Quercetin, Rosmarinic acid and Catechin were found to bind to survivin protein effectively. These substances can have the potential to become active pharmaceutical ingredients by working with different proteins in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of Antioxidant Activities of Viscum album L.: First Report on Interaction of Phenolics with Survivin Protein using in silico Analysis

et al. 2023

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Biological activities of Viscum tuberculatum aqueous leaf extract

Yirgu

Mekonnen

Eyado

et al. 2022

Pharmaceutical Biology

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Effects of Newboldia laevis (ogirisi) on mercury chloride – induced kidney damage in adult male Wistar rats

2023

JoSVAS

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Drug-induced injury is a key cause of kidney disease. Mercuric chloride, an antineoplastic agent used for treating various malignancies can cause kidney injury and induce nephrotoxicity. This study was to determine the effects of Newbouldia laevis on mercury chloride- induced kidney damage in adult male Wistar rats. Twenty-five adult male Wistar rats weighing between 110 – 200g were used for this study. The animals were allocated to five groups: A to E with five rats per group. Group A served as the control group and was administered 1ml of distilled water daily. Group B received a low dose of Newbouldia laevis (200mg/kg body weight) for 28 days along with Mercuric chloride (10mg/kg body weight). Group C received an intermediate dose of Newbouldia laevis (400mg/kg) for 28 days with Mercuric chloride (10mg/kg). Group D received a high dose of Newbouldia laevis (800mg/kg) for 28 days with Mercuric chloride (10mg/kg). Group E received only Mercuric chloride (10mg/kg) daily for 28 days. Rats in each group were allowed unrestricted access to water and feed during the experiment. Intracardial collection of blood from the Wistar rats was carried out in each group and the kidney function were assessed. The kidney tissues were processed for light microscopy study. Group A kidney tissues showed normal tubules, glomeruli, and interstitial spaces. Group E showed mercuric chloride-induced kidney injury: perivascular infiltrates of inflammatory cells; patchy tubular necrosis. Group D showed amelioration of the damages caused by Mercuric chloride. It can be concluded that Newbouldia laevis ameliorated Mercuric chloride – induced kidney damage in dose-dependent-pattern.

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Sub-acute oral toxicity and in vivo antioxidant properties of Oxalis cernua

Cited by 3 publications

References 34 publications

Determination of Antioxidant Activities of Viscum album L.: First Report on Interaction of Phenolics with Survivin Protein using in silico Analysis

Determination of Antioxidant Activities of Viscum album L.: First Report on Interaction of Phenolics with Survivin Protein using in silico Analysis

Biological activities of Viscum tuberculatum aqueous leaf extract

Effects of Newboldia laevis (ogirisi) on mercury chloride – induced kidney damage in adult male Wistar rats

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