Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice

Bakre, Adewale G.; Aderibigbe, Adegbuyi Oladele; Ademowo, Olusegun G.

doi:10.1016/j.jep.2013.08.006

Cited by 90 publications

(74 citation statements)

References 35 publications

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“…These results are in according to [118], who documented that moringa leaf extracts are non-lethal at 2000 mg/kg and [104], whose publication demonstrated that ethanol extract from moringa leaves were not toxic to mice and revealed a LD 50 higher than 6.4 g/kg in oral acute toxicity studies. Nevertheless, i.p.…”

Section: Leaves Flowers and Rootssupporting

confidence: 58%

“…In this event, it is possible that these activities are mediated through the enhancement of central inhibitory mechanism involving release γ-amino butyric acid (GABA) [104]. These findings partially justified the traditional use of M. oleifera parts for the treatment of epilepsy.…”

Section: Action On Central Nervous System (Cns)mentioning

confidence: 94%

“…Abortifacient Leaves, roots [113], [114] Against Plasmodium falciparum and Schistosoma mansoni cercariae Seeds [105], [106] Analgesic Roots [27], [84] Antiatherosclerotic Leaves [69] Anticlastogenic Leaves, pods [63], [64] Anti-constipant Flowers [109] Anticonvulsant Leaves, roots [27], [103], [104] Antiespasmodic Leaves, seeds [80] Antihelminthic Seeds [53] Anti-inflammatory Seeds, leaves, roots [80], [81], [82], [83] Antioxidant Leaves, seeds [24], [25], [26], [63], [67], [68], [70] Antipyretic Leaves [18] Antitumor Seeds, stem, leaves [68], [72], [87], [88] Antiulcerogenic Leaves, seeds [65], [66] Bactericidal Leaves, stem, pods [17], [93], [97], [94], [95], [96] Bradycardic/Hipotensive Seeds [77], [78], [79] Diuretic Seeds [80] Fungicide Leaves, seeds [91], …”

Section: Part Of Plant Referencementioning

confidence: 99%

See 2 more Smart Citations

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Ferreira¹,

Araújo²,

Freitas³

et al. 2014

Pharmacology and Therapeutics

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Section: Leaves Flowers and Rootssupporting

confidence: 58%

Section: Action On Central Nervous System (Cns)mentioning

confidence: 94%

Section: Part Of Plant Referencementioning

confidence: 99%

See 1 more Smart Citation

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Ferreira¹,

Araújo²,

Freitas³

et al. 2014

Pharmacology and Therapeutics

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“…(Bakre et al, 2013;Saha et al, 2013), and finally, ethanol extracts typically dissolve in water or aqueous physiologic solutions (e.g., 0.9% normal saline used to buffer IV drugs) that facilitate intravenous injection for future pre-clinical/clinical assays both in mice or in patients with leukemia. Extracts were concentrated to a solid paste using a rotavapor, lyophilized and stored at À20 C until used.…”

Section: Introductionmentioning

confidence: 99%

Pro-apoptotic effect ofPersea americanavar.Hass(avocado) on Jurkat lymphoblastic leukemia cells

Bonilla-Porras

Salazar-Ospina

Jiménez-Del-Río

et al. 2013

Pharmaceutical Biology

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Context: Therapy for leukemia has a limited efficacy. There is a need to search for alternative anti-leukemia therapies. Persea americana Mill var. Hass (Lauraceae) is a tropical fruit (avocado) that might be used against cancer. Objective: To investigate whether P. americana induces death in Jurkat lymphoblastic leukemia cells. Materials and methods: Four ethanol extracts (0.1, 0.5, 1, 2 and 5 mg/mL) from avocado fruit (endocarp, whole seed, seed and leaves) were analyzed against Jurkat cells. Hydrogen peroxide generation by oxidation of 2 0 ,7 0 -dichlorodihydrofluorescein diacetate to the fluorescent compound 2 0 ,7 0 -dichlorfluorescein assay, acridine orange/ethidium bromide staining, flow cytometry analysis of annexin-V/7-amino-actinomycin, mitochondrial membrane potential and immunocytochemistry detection of transcription factor p53, caspase-3 and apoptosis-inducing factor (AIF) were evaluated. Results: Endocarp, seed, whole seed, and leaf (0.1 mg/mL) extracts induced significant apoptosis in Jurkat cells (p50.001) in an oxidative stress-dependent fashion via mitochondrial membrane depolarization (52-87%), activation of transcription factor p53 (6.3-25.4%), protease caspase-3 (8.3-20%) and predominance of AIF reactivity (20.6-36%) in all extracts. Similar results were obtained with 0.5 mg/mL extracts. However, extract !1 mg/mL concentration induced necrosis (100%). Conclusions: P. americana extracts function as a pro-apoptotic compound. Leukemic cells are eliminated through an oxidative stress mechanism. This study contributes to the understanding of the molecular mechanism of the avocado and its therapeutic action on leukemia.

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“…Oleifera is commonly referred to as either Horse Radish tree (referring to the taste of its roots) or Drumstick tree (describing the shape of its pods) (Shih et al, 2011) while less frequently referred to as 'The Tree of Life' or 'Miracle Tree' due to its economical importance and versatility (Abe and Ohtani 2013; Bakre et al, 2013). A single genus with 14 known species, M. oleifera is the most widely known and utilized of these (Morton, 1991).…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera (Shajna): the wonderful indigenous medicinal plant

Taher

Nyeem

Ahammed

et al. 2017

Asian J. Med. Biol. Res

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'The Tree of Life' or 'Miracle Tree' is the name of the plant of Moringa oleifera (Shajna). Moringa oleifera is one of the important plants in plant kingdom. Its leaves and fruits are used as vegetable in Indian sub continent, at the same time each part of the plant rich with some important medicinal values. It is now considered as a valuable source of several unique products for the medicines against various diseases. The present review is to focus on the nutritive values, physico-chemical properties, phyto-chemicals and pharmacological activities of M. oleifera. Various parts of the plant like seeds, leaves, flowers, bark and fruits have been investigated for their significant pharmacological activity. Phyto-chemicals like flavanoid, anthraquinone, alkaloids, essential oils, tannic acid, carotene, glucose have been reported for significant antioxidant, hepatoprotective, anticancer, aphrodisiac, antiinflammatory, antihyperlipidaemic, antihyperglycaemic and antiulcer activities of Drumstick tree and emphasizes the need for further exploring available information.

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Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice

Cited by 90 publications

References 35 publications

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Pro-apoptotic effect ofPersea americanavar.Hass(avocado) on Jurkat lymphoblastic leukemia cells

Moringa oleifera (Shajna): the wonderful indigenous medicinal plant

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