Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Ferreira, Paulo Michel Pinheiro; Araújo, Jurandy do Nascimento Silva Éverton José Ferreira de; Freitas, Rivelilson Mendes de; Costa, NagillaDaniela de Jesus; Oliveira, Janiella Buenos Aires Pereira Samara Ferreira de Carvalho; Pinheiro, Jaksilania Aires Forte; Abreu, MariaCarolina de; Pessoa, Cláudia

doi:10.5772/58627

Cited by 3 publications

(5 citation statements)

References 98 publications

(175 reference statements)

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“…Acute toxicity test in vitro on brine shrimp lethality test as initial research for further research regarding considerations in consuming Moringa oleifera leaves as vegetable soup and traditional medicinal plants brewed using water solvent with excellent and safe efficacy. The quality of the commercialized medicinal plants, the population inexperience, the origin of the plant, period and methods of collection, storage, drying, packaging, contamination by fungi and other microorganisms and the quantity ingested are factors that obscure the diagnosis and complicate the treatment in cases of poisoning by toxic plants [16]. Toxicity in the use of traditional medicinal plants may occur due to the intrinsic toxicity of the plant and the effect of acute overdose.…”

Section: Resultsmentioning

confidence: 99%

“…In carcinogenesis studies, niazimicin-treated animals showed a delay in skin carcinoma formation induced by DMBA (initiator) and TPA (12-Otetradecanoylphorbol-13-acetate, promoter), and they also revealed reducing in the number of papillomas. Antioxidants might be very effective in combating cancer [16] [20]. The Moringa oleifera extract caused emerging of apoptotic bodies, chromatin condensation, cell shrinking, DNA fragmentation and induced the generation of reactive oxygen species (ROS) in epidermoid carcinoma KB cells, and it is believed that Moringa oleifera antiproliferative activity is related to the intrinsic apoptosis pathway(s), probably because of the cytochrome c release from mitochondria following ROS production [20].…”

Section: Resultsmentioning

confidence: 99%

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The Lethality Dose and Antioxidant Activity of Moringa Oleifera Leaves Extract

Pradana

Rahmi

Muti

2022

IOP Conf. Ser.: Earth Environ. Sci.

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Moringa oleifera leaves for traditional medicinal plants and as food has been widely used in Indonesia and several regions in the world by boiling Moringa oleifera leaves using water as a solvent before consumption. Moringa oleifera leaves contain active compounds such as phenols,flavonoids and tannins. These active compounds can be helpful as an antioxidant. The purpose of this study was to evaluate the antioxidant activity and lethality dose of the aqueous extract of Moringa oleifera leaves. The method used to obtain the LC50 value is using the Brine Shrimp Lethality Test. The final concentration tested Moringa oleifera leaves were 50, 100, 500 and 1000 ppm. Antioxidant activity test using UV-Visible spectrophotometric method with DPPH to obtain the IC50 value of Moringa oleifera leaf aqueous extract. The results of the LC50 of Moringa oleifera leaf aqueous extract were 475.15 ppm, and the IC50 value of Moringa oleifera leaf aqueous extract was 217.21 mg/g with a moderate antioxidant value. This study concludes that the aqueous extract of Moringa oleifera leaves is medium toxic based on Clarkson's toxicity criterion with moderate antioxidant value.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Lethality Dose and Antioxidant Activity of Moringa Oleifera Leaves Extract

Pradana

Rahmi

Muti

2022

IOP Conf. Ser.: Earth Environ. Sci.

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“…Effect of different duration combinations for the coagulation and flocculation steps when using M. oleifera seed powder for the harvest of a mixed culture of Chlorella and Desmodesmus (seed powder concentration of 500 mg L −1 , pH 8, coagulation and flocculation rotation speeds of 150 rpm and 30 rpm, respectively). The effect of sedimentation duration (20,40, or 60 min) on the harvesting efficiency is also shown. Different letters indicate significant differences between the flocculation times after a one-way ANOVA followed by a Tukey test (p < 0.05).…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…It has also been shown to be effective for microalgae harvesting, as its seeds contain a protein that can be used as a natural organic flocculant [18,19]. In addition, it was shown to reduce bacterial content by 99.9% [20], an important aspect of the food and feed industry.…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Lam. as a Bioflocculant for Harvesting Microalgae Grown on Agricultural Wastewaters for Feed Production

et al. 2022

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Harvesting impacts the costs of microalgae production and affects the characteristics of the final product. Therefore, this study evaluated Moringa oleifera seed powder (MP) as a bioflocculant compared to two chemicals (Aluminium Sulphate—AS and Iron Chloride—IC) to harvest a mixed microalgae culture (Chlorella vulgaris and Desmodesmus sp.) grown on digestate. MP was the most stable flocculant but resulted in the lowest harvesting efficiency of 75%, compared to 94% for AS and 100% for IC. Process parameters such as pH, duration of mixing, grinding method for obtaining the powder, and granulometry had no significant effect on the harvesting efficiency of MP, reinforcing that this is a robust flocculant. The use of a water extraction step increased the harvesting efficiency of MP to 91%, albeit with the need for a higher dosage of flocculant. The algae harvested with MP complied with maximum tolerable levels for swine, cattle, and poultry regarding most trace elements. Nevertheless, all algae samples had Fe and Al contents above the recommended levels, possibly due to the entrapment of metal-rich digestate particles. Therefore, more attention should be paid to the final composition of algae when proposing flocculation as a harvesting method for feed production.

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“…and their elemental composition have been shown to possess medicinal values. 3,4 A growing concern in the development and evaluation of natural antioxidants from medicinal plants mainly in the field of preventive health care and the food industry is reported. Among those herbs, one promising species is Moringa oleifera Lam (Moringa or drumstick tree), which is native to the sub-Himalayan regions of Northwest India.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Ethanolic Extract of Moringa Oleifera Seed on Bleeding Time and Whole Blood Clotting Time of Wistar Albino Rats

Singnap¹,

Sabo²,

Idah³

et al. 2019

IJMLR

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Background: It is estimated that over 80% of people still depend mainly on the traditional use of parts of plants and herbs to treat ailments. The medicinal properties of these plants and herbs are linked to the presence of a variety of phytochemicals and their elemental composition. Justification: Every year, 1 in 4 people die of conditions related to thrombosis, with many never knowing their risk for the condition. Prevention of intravascular thrombosis, however, has a narrow therapeutic window, bleeding risk, the incidence of resistance, and unwanted drug interactions, hence the need for anti-thrombotic drugs that deliver more effective prevention of intravascular thrombosis. Aim: The research sought to investigate the effect of Moringaoleifera ethanolic seed extract on Bleeding Time (BT) and Clotting Time (CT), in Wistar albino rats. Materials and Methods: Forty (40)Wistar rats were weighed and randomly divided into two groups, group I=15 rats for BT, group II=15 rats for CT and 10 rats for control tests. After the administration of ethanolic extract of M. oleifera seed at the dose of 100mg/kg, 200mg/kg and 400mg/kg (administered to a group of 5 rats per dose) for 28 days, BT and CT were determined using Tail transection and Lee & White method respectively. The data were analysed using GraphPadPrism (7.03). Result: There was a statistically significant increase at P <0.0001 of BT and CT compared to the control (administered with only distilled water). Conclusion: The prolonged BT and CT indicate that the seed extract of M. oleifera could pose an antagonising effect on both the primary (platelets) and secondary haemostatic activities, a property that can be explored in the management of thrombotic diseases.

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Safety and Efficacy of Moringa oleifera Lamarck (1785) — Therapeutic and Toxicological Properties

Cited by 3 publications

References 98 publications

The Lethality Dose and Antioxidant Activity of Moringa Oleifera Leaves Extract

The Lethality Dose and Antioxidant Activity of Moringa Oleifera Leaves Extract

Moringa oleifera Lam. as a Bioflocculant for Harvesting Microalgae Grown on Agricultural Wastewaters for Feed Production

Investigating the Effect of Ethanolic Extract of Moringa Oleifera Seed on Bleeding Time and Whole Blood Clotting Time of Wistar Albino Rats

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