Pro-apoptotic effect of<i>Persea americana</i>var.<i>Hass</i>(avocado) on Jurkat lymphoblastic leukemia cells

Bonilla-Porras, Angélica R; Salazar-Ospina, Andrea; Jiménez-Del-Río, Marlene; Pereañez-Jimenez, Andres; Vélez-Pardo, Carlos

doi:10.3109/13880209.2013.842599

Cited by 28 publications

(15 citation statements)

References 28 publications

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“…Previous results have shown that early stage premalignant cell lines TE1177/HPV16/ E6 and TE1177/HPV16/E7 contain high levels of ROS; incubation with D003 extract increased their basal levels and induced apoptosis, but only caused a small increase in the primary parent TE1177 cells [11]. This was also found to be true in Jurkat lymphoblastic leukemia cells where avocado extract induced ROS-dependent apoptosis [46]. In the current study, we observed that DMBA treated buccal mucosa contained higher levels of ROS and that topical application of avocado D003 extract further increased the ROS levels.…”

Section: Discussionsupporting

confidence: 63%

“…Garcinol from fruit rind of Garcinia spp., for example, has been found to inhibit cell proliferation in DMBAinduced HCP carcinogenesis [39]. Avocado extract has been shown to: i) inhibit EGRK/RAF/MEK/ERK1/2 pathways [8] and Cyclin D1 (our unpublished data) and over-expression of MEK/ERK1/2 that partially overcomes D003 reduced cell proliferation [8]; ii) up-regulate p21 [7] and our unpublished data); and, iii) enhance ROS and induction of apoptosis [7,11,46]. It has been reported that targeting EGFR in the DMBA/HCP model reduces cell proliferation [47].…”

Section: Discussionmentioning

confidence: 99%

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Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracene (DMBA)- Induced Carcinogenesis in Hamster Cheek Pouches

Ding¹,

Casto²,

Deng³

et al. 2014

Med chem

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracene (DMBA)- Induced Carcinogenesis in Hamster Cheek Pouches

Ding¹,

Casto²,

Deng³

et al. 2014

Med chem

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show abstract

“…The analysis of intracellular ROS production was carried out according to Bonilla-Porras et al [21]. Briefly, 5 × 10 4 cells were incubated with dichlorofluorescein diacetate (DCF-DA) at 10 μM final concentration for 25 min at 37 °C in the dark.…”

Section: Methodsmentioning

confidence: 99%

Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

Bonilla-Ramirez

Galiano

Quiliano

et al. 2019

Malar J

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Background The challenge in anti-malarial chemotherapy is based on the emergence of resistance to drugs and the search for medicines against all stages of the life cycle of Plasmodium spp. as a therapeutic target. Nowadays, many molecules with anti-malarial activity are reported. However, few studies about the cellular and molecular mechanisms to understand their mode of action have been explored. Recently, new primaquine-based hybrids as new molecules with potential multi-acting anti-malarial activity were reported and two hybrids of primaquine linked to quinoxaline 1,4-di- N -oxide (PQ–QdNO) were identified as the most active against erythrocytic, exoerythrocytic and sporogonic stages. Methods To further understand the anti-malarial mode of action (MA) of these hybrids, hepg2-CD81 were infected with Plasmodium yoelii 17XNL and treated with PQ–QdNO hybrids during 48 h. After were evaluated the production of ROS, the mitochondrial depolarization, the total glutathione content, the DNA damage and proteins related to oxidative stress and death cell. Results In a preliminary analysis as tissue schizonticidals, these hybrids showed a mode of action dependent on peroxides production, but independent of the activation of transcription factor p53, mitochondrial depolarization and arrest cell cycle. Conclusions Primaquine–quinoxaline 1,4-di- N -oxide hybrids exert their antiplasmodial activity in the exoerythrocytic phase by generating high levels of oxidative stress which promotes the increase of total glutathione levels, through oxidation stress sensor protein DJ-1. In addition, the role of HIF1a in the mode of action of quinoxaline 1,4-di- N -oxide is independent of biological activity.

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“…P. americana fruits are commonly known as “avocados.” Nowadays, a likely anticancer activity of P. americana (avocado) seeds, most often thrown away, has generated growing scientific interest. Indeed, the ethanol extract of P. americana seeds was found stimulating apoptosis of Jurkat lymphoblastic cells [ 17 ]. The cytotoxic effect of the same extract was also reported on breast cancer cell line (MCF-7) and human liver cancer cell line (HepG2) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis

Essono

Mvondo

Ngadjui

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Endometriosis is an estrogen-dependent disease with conventional therapies which do not have desirable effectiveness and possess many side effects. Scientific evidences suggest that medicinal plants with antioxidant, anti-inflammatory, and/or antiproliferative properties are potential alternatives for the treatment of endometriosis. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro and in vivo. This study therefore is aimed at investigating the effects of such an extract on an experimental model of endometriosis. Endometriosis was induced by grafting uterine fragments onto the peritoneum of female Wistar rats. After checking the success of the transplantation surgery, animals with endometriosis were orally treated with the ethanol extract of P. americana seeds at the doses of 12.5, 25, and 50 mg/kg. The positive control was treated with letrozole (10 mg/kg) while the negative control received the vehicle. Treatments lasted 7 days and animals were sacrificed thereafter. Endometrial implant volume was determined. Estradiol and progesterone levels were measured in serum samples and endometriosis lesions. The oxidative status of endometriosis lesions was evaluated. Histological analysis of endometriosis lesions, uterus, and ovaries was also performed. Results showed that the ethanol extract of P. americana seeds decreased endometrial implant volume (p<0.001) and serum levels of estradiol and progesterone (p<0.01). The levels of estradiol also decreased in endometriosis lesions at doses of 12.5 and 50 mg/kg (p<0.001). Both malondialdehyde and glutathione levels increased in endometriosis lesions (p<0.001). The ectopic endometrium height decreased and the number of antral follicles and corpora lutea (p<0.05) increased while that of luteinized unruptured follicles decreased (p<0.001). In conclusion, the ethanol extract of P. americana seeds displayed an antiendometriosis effect suggesting that it could be a potential alternative for the treatment of endometriosis.

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Pro-apoptotic effect ofPersea americanavar.Hass(avocado) on Jurkat lymphoblastic leukemia cells

Cited by 28 publications

References 28 publications

Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracene (DMBA)- Induced Carcinogenesis in Hamster Cheek Pouches

Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracene (DMBA)- Induced Carcinogenesis in Hamster Cheek Pouches

Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis

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