Stimuli-responsive protein-based micro/nano-waveguides

Hou, Zhi‐Shan; Sun, Siming; Zheng, Bo-Yuan; Yang, Ruizhu; Li, Aiwu

doi:10.1039/c5ra15538j

Cited by 11 publications

(9 citation statements)

References 41 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deep transport of diagnostic and/or therapeutic light to targeted cells could be performed by the use of optical passive and active FL waveguides. [ 23–27 ] The passive waveguiding property is based on the total internal reflection phenomenon, which provides optical confinement of the propagating light wave in transparent elongated dielectric structures (e.g., fibers, tubes, and tapes). Another type of passive light propagation is FL waveguiding in which visible FL is excited from organic dyes incorporated into waveguiding structure.…”

Section: Introductionmentioning

confidence: 99%

“…The FL signal, excited by the input optical beam, propagates as an FL wave in the transmitting waveguide. [ 23,28–31 ] In biomedical technology, such optical waveguides are fabricated from natural and synthetic polymer and hydrogel biocompatible materials and used for drug‐delivering imaging, light‐controlled therapy, cell‐based sensing, and optogenetics. [ 29,32–35 ]…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long‐Range Fluorescence Propagation in Amyloidogenic β‐Sheet Films and Fibers

Apter

Fainberg

Handelman

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

Newly developed PEGylated phenylalanine peptide derivatives (PEG‐F6) can self‐assemble to form hybrid multifunctional nanostructures of homogeneous thin polymer films and amyloid‐like fibers. Both adopt a β‐sheet architecture and acquire the unique properties of visible fluorescence (FL) found in β‐sheet amyloid fibrils also associated with neurodegenerative diseases. A new paradigm observed in PEG‐F6 amyloid‐like fibers is reported, which demonstrates unique FL and optical absorption (OA) covering the entire visible region. Despite the full overlap of the FL and OA spectra, the FL propagates for an unexpectedly large distance of hundreds of micrometers in these fibers. A new non‐waveguiding mechanism of FL light energy transfer in amyloidogenic fibers is proposed based on photon reabsorption theory. The discovered quasi‐white FL of PEG‐F6 β‐sheet amyloidogenic fibers and films consists of the newly observed green FL band along the known blue FL band. The proof‐of‐concept of long sub‐millimeter range FL propagation in specially grown amyloidogenic PEG‐F6 fiber‐photonic probes is reported. The results indicate that FL can propagate in nanoscale fibers and suggest biomedical applications for FL monitoring of disease‐related ultrathin amyloid fibrils and in integrated photonics for optogenetics.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long‐Range Fluorescence Propagation in Amyloidogenic β‐Sheet Films and Fibers

Apter

Fainberg

Handelman

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

“…To achieve such a dream, choosing natural biomaterials such as nucleic acids, peptides, proteins, and polysaccharides as the substitutes of fossil source‐based synthetic chemicals is a promising way. Correspondingly, micro/nanoscale fabrication on natural biomaterials receives great of importance, and a spatially definable property with high precision to exactly position biomaterials on a surface is highly desirable toward biodegradable and biocompatible green electronic, optical, sensor, energy, and environmental devices . Typical examples down this road include silk fibroin, polysaccharides, and DNA origami‐mediated lithography .…”

Section: Introductionmentioning

confidence: 99%

Water‐Based Photo‐ and Electron‐Beam Lithography Using Egg White as a Resist

Jiang

Yang

et al. 2017

Adv Materials Inter

View full text Add to dashboard Cite

human life. [1][2][3] To achieve such a dream, choosing natural biomaterials such as nucleic acids, [4][5][6] peptides, [7] proteins, [8,9] and polysaccharides [10] as the substitutes of fossil source-based synthetic chemicals is a promising way. Correspondingly, micro/ nanoscale fabrication on natural biomaterials receives great of importance, [11] and a spatially definable property with high precision to exactly position biomaterials on a surface is highly desirable [12][13][14][15][16][17][18] toward biodegradable and biocompatible green electronic, [19][20][21][22] optical, [23][24][25][26][27][28][29] sensor, [30] energy, [31] and environmental devices. [32] Typical examples down this road include silk fibroin, [12][13][14] polysaccharides, [10] and DNA origami-mediated lithography. [5] These approaches are part of great efforts to develop "green" lithographic processing in semiconductor industry that is eligible to lessen the exposure of workers and environment toward noxious chemical and reduce waste. [13] The adoption of these strategies allows the replacement of organic solvent with water to cast and develop a resist, accompanied with the exclusion of environmentally harmful components from material processing and fabrication. However, so far the lithographic processes based on existing natural biomaterials are difficult to be exploited in scale-up industrial application, because their limited quantities, high material, and processing cost as well as small deposition area impede the practical engineering of these biomaterials. [9] Moreover, the less-controlled variation on polymorph and polydispersity of biomaterials often influences the repeatability of results. [33] Recently, our group reported the use of phase-transited lysozyme nanofilm as the resist for photolithography and electron-beam lithography (EBL), with the cost being decreased and practical applicability being potentially demonstrated. [17] Continuous efforts along this way further require much cheaper material and simpler fabrication process for large-scale industrial uses. In this respect, we pay attention to egg white due to the following reasons. First, egg white is a very common natural biomaterial just taken from egg as our daily food, which makes it has great natural abundance with a low cost. Second, in contrast to other natural competitors usually requiring strict demands on the purity, polydispersity, and polymorph stability, egg white is a combination of multiple functional nutrients, [34] which could be directly utilized without further purification and Complex lithographic steps and the use of toxic chemicals in these processes are in conflict with a sustainable human society. Development of new inexpensive and green resist, simple alternative procedures, and nontoxic solvents is the key to move recyclable micro/nanofabrication from laboratory level to industrial application in large scale. Herein, precise control on protein fragmentation/aggregation upon photo/electron irradiation is conceived into egg white-based green resist...

show abstract

“…[11][12][13] Until now, various twodimensional and three-dimensional micro-nano photonic devices with high quality have been successfully demonstrated by femtosecond laser processing. [14][15][16][17] Whispering gallery mode (WGM) microcavities which possess high quality factor (Q) and small volume have shown promising applications in many areas such as sensing, 18 lasing 5,6 and optical information processing. 19 In addition, they have been widely used in fundamental researches, such as cavity quantum electrodynamics.…”

mentioning

confidence: 99%