Stem Cell Therapy: Curcumin Does the Trick

Sharifi, Simin; Vahed, Sepideh Zununi; Ahmadian, Elham; Dizaj, Solmaz Maleki; Abedi, Atefeh; Khatibi, Seyed Mahdi Hosseiniyan; Samiei, Mohammad

doi:10.1002/ptr.6482

Cited by 49 publications

(27 citation statements)

References 106 publications

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“…Curcumin also contributes to the differentiation of some stem cells [ 44 ] and promotes apoptosis in leukemia cells in vitro [ 45 ]. It appears that certain nutrients, vitamins, and antioxidants such as flavonoids could play roles in maintaining the self-renewal of stem cells and could also stimulate the proliferation and differentiation of progenitors, which are required for the replacement of mature cells in the blood and tissues [ 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…It appears that certain nutrients, vitamins, and antioxidants such as flavonoids could play roles in maintaining the self-renewal of stem cells and could also stimulate the proliferation and differentiation of progenitors, which are required for the replacement of mature cells in the blood and tissues [ 46 , 47 , 48 ]. Because certain natural compounds have been found inhibit the growth of tumor cells lines, the synergic supplementation with antioxidants could promote the normal growth of stem cells needed for healing (for example) while also reducing tumorogeneicity potential [ 44 ]. These antioxidants could also push normal HSC stem cells into desired phenotypes specific for certain disorders [ 46 , 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

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The Bluegreen Algae (AFA) Consumption over 48 h Increases the Total Number of Peripheral CD34+ Cells in Healthy Patients: Effect of Short-Term and Long-Term Nutritional Supplementation (Curcumin/AFA) on CD34+ Levels (Blood)

Merino

Cabaña-Muñoz

Pelaz³

2020

JPM

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Several active principles from plants could trigger the release of stem cells from the bone marrow. Stem cell mobilizers have shown side effects in patients. Thus, the purpose of this paper is to find the natural products from plants (curcuminoids, glycosinolate of sulforaphane, AFA bluegreen algae), which could be potential stem mobilizes without adverse side effects. The antioxidant curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-2,5-dione], glycosinolate of sulforaphane (broccoli) or AFA (Aphanizomenon flos) extract promote beneficial effects in patients. The number of circulating stem cells were monitored by HSC marker-CD34 by flow cytometry in peripheral blood from healthy subjects. CD34 is a hematological stem cells (HSC) marker. A double-blind study was conducted in 22 healthy subjects. We have evaluated whether short-term AFA—Aphanizomenon flos aquae—algae or curcuminoids consumption (powder or liquid formulation) over 48 consecutive hours could increase the total number of peripheral CD34+ blood cells (n = 22, n = 5 subjects/group). The total number of circulating CD34+ cells were quantified after short-term and long-term nutritional supplementation; their levels were compared with their own basal levels (n = 5/group, controls: before taking any supplement) or placebo-treated patients (n = 7); their average age was 54 years old. We also evaluated whether long-term nutritional supplementation with several nutraceuticals could enhance HSC mobilization by increasing the total number of peripheral CD-34+ cell after seven or 38 consecutive days of administration (n = 5, with seven placebo-treated patients). The long-term administration take place with these doses/day [curcuminoids: 2000 mg/day, equivalent to 120 mg of curcuminoids/day), glycosinolate of sulforaphane (66 mg/day), plus AFA Algae bluegreen extract (400 mg/day)]. On the last day (10 a.m.) of treatment, blood samples were collected six hours after taking these supplements; the average age was 54 years old. Notably, the blue green AFA algae extract consumption over 48 h enhances HSC mobilization by increasing the total number of peripheral CD34+ cells. The long-term administration with curcuminoids, glycosinolate of sulforaphane, and AFA bluegreen algae extract also increased the total number of CD34-HSC cells after seven or 38 days of consecutive of administration in healthy subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Bluegreen Algae (AFA) Consumption over 48 h Increases the Total Number of Peripheral CD34+ Cells in Healthy Patients: Effect of Short-Term and Long-Term Nutritional Supplementation (Curcumin/AFA) on CD34+ Levels (Blood)

Merino

Cabaña-Muñoz

Pelaz³

2020

JPM

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“…It is poorly absorbed orally and can be rapidly metabolized and removed from the circulatory system. There are several ways to resolve these problems; and the use of curcumin nanoparticles is the main way to increase bioavailability for curcumin (Sharifi et al, 2019; A. K. Singh et al, 2013). The field of nanotechnology has been the most active field of research in modern biotechnology and has been significantly developed.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study

Negahdari

Ghavimi

Barzegar

et al. 2020

Clinical & Exp Dental Res

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Objectives Infections after implant placement are the main reasons for the failure of implant treatments. The present study aimed to evaluate the antibacterial effects of nanocurcumin inside the implant fixture against Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. Materials and Methods Twenty seven implants were classified in three groups for testing the antibacterial effect of nanocurcumin, chlorhexidine (as negative control), and distilled water (as negative control). Each group was then divided into three subgroups to study the effect of the applied torque on the antimicrobial effect of nanocurcumin. All implant abutment assemblies were submerged in bacteria suspension and were incubated at 37°C for 24 hours. The contents of each implant were removed to count the colony of bacteria on the surface of plates containing nutrient agar. Results Results indicated that the inhibitory rate of bacteria by nanocurcumin was above 99% in all bacteria. Besides, by increasing the amount of applied torque from 10 to 35 N.cm, the CFU of bacteria in exposure to nanocurcumin significantly were decreased (p‐value < 0.01). Conclusion The results of this study revealed that nanocurcumin can be used inside the implant fixture in order to use antimicrobial effects and further stabilization and success of the implant.

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“…Curcumin (1,7-bis (4-hydroxy-3-mrthoxyphenyl) -1,6-heptadiene-3,5-dione) is extracted from rhizome of the turmeric [7,8]. Curcumin has long been utilized as a safe coloring agent in Asia and is applied in traditional medicine for several therapeutic purposes [9].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Nanocrystals: Production, Physicochemical Assessment, and In Vitro Evaluation of the Antimicrobial Effects against Bacterial Loading of the Implant Fixture

et al. 2020

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Background: This study aimed to prepare and study physicochemical properties as well as the antibacterial action of curcumin nanocrystals inside the implant fixture against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Enterococcus faecalis (E. faecalis). Methods: Curcumin nanocrystals were prepared via precipitation combined with the spray drying method. The produced curcumin nanocrystals were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FTIR). Moreover, the in vitro antimicrobial effect of curcumin nanocrystals inside the implant fixture was assessed against E. coli, S. aureus, and E. faecalis. All implant-abutment assemblies were immersed in bacterial suspensions and were incubated at 24, 48, and 72 h. The contents of each implant were cultured to count the colony of bacteria at 37 °C for 24 h. Results: The prepared curcumin nanocrystals with a mean particle size of 95 nm and spherical morphology exhibited a removal rate of 99.99% for all bacteria. In addition, the colony-forming unit (CFU) of bacteria in exposure to nanocrystals significantly was reduced (p < 0.010) by increasing the time. Conclusions: Curcumin nanocrystals can be used inside the implant fixture as an antimicrobial agent in order to more stabilization of the implant.

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Stem Cell Therapy: Curcumin Does the Trick

Cited by 49 publications

References 106 publications

The Bluegreen Algae (AFA) Consumption over 48 h Increases the Total Number of Peripheral CD34+ Cells in Healthy Patients: Effect of Short-Term and Long-Term Nutritional Supplementation (Curcumin/AFA) on CD34+ Levels (Blood)

The Bluegreen Algae (AFA) Consumption over 48 h Increases the Total Number of Peripheral CD34+ Cells in Healthy Patients: Effect of Short-Term and Long-Term Nutritional Supplementation (Curcumin/AFA) on CD34+ Levels (Blood)

Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study

Curcumin Nanocrystals: Production, Physicochemical Assessment, and In Vitro Evaluation of the Antimicrobial Effects against Bacterial Loading of the Implant Fixture

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