Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study

Abstract

Objectives Infections after implant placement are the main reasons for the failure of implant treatments. The present study aimed to evaluate the antibacterial effects of nanocurcumin inside the implant fixture against Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. Materials and Methods Twenty seven implants were classified in three groups for testing the antibacterial effect of nanocurcumin, chlorhexidine (as negative control), and distilled water (as negative control). Each group was then divided into three subgroups to study the effect of the applied torque on the antimicrobial effect of nanocurcumin. All implant abutment assemblies were submerged in bacteria suspension and were incubated at 37°C for 24 hours. The contents of each implant were removed to count the colony of bacteria on the surface of plates containing nutrient agar. Results Results indicated that the inhibitory rate of bacteria by nanocurcumin was above 99% in all bacteria. Besides, by increasing the amount of applied torque from 10 to 35 N.cm, the CFU of bacteria in exposure to nanocurcumin significantly were decreased (p‐value < 0.01). Conclusion The results of this study revealed that nanocurcumin can be used inside the implant fixture in order to use antimicrobial effects and further stabilization and success of the implant.

Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds

“…In these studies, ER stress, Wnt/β-catenin, Akt/GSK3β, and Keap1/Nrf2/HO-1 signaling pathways were introduced as potential mechanisms of curcumin for the The scaffolds of coaxial electrospun nanofibers using GO and Zn-CUR complex for bone regeneration [52] (adopted with permission). 6 Stem Cells International induction of osteoblastic differentiation of MSCs. These findings demonstrated that curcumin can prevent osteoclast and osteoblast differentiation through the BMP/Smad and JNK/Bax mechanisms.…”

“…Recently, it received significant attentions as a medicinal plant due to its unique therapeutic benefits including antipathogenic, antioxidant, anti-inflammation, antiangiogenic, anticancer, and antidiabetic effects, as treatment for central nervous system and cardiovascular disorders, in skin diseases and the cosmetic industry, lung diseases, antiatherosclerotic, ophthalmic, cystic fibrosis and osteoporosis, beta-thalassemia, etc. [5][6][7][8]. Also, it was reported as a valuable material in nutritional supplements due to the pleiotropic pharmacological properties [9].…”

“…Despite its multitarget biological effects, there are limitations to its clinical use due to its low absorption, bioavailability, and short half-life. Recently, several nanoparticles such as solid lipid nanoparticles, nanostructured lipid carriers, liposomes, micelles, nanogels, and magnetic nanoparticles are developed as novel and potential therapeutic strategies to improve therapeutic effects of various drugs such as curcumin [5][6][7][8][9][10][11].…”

Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin

“…Curcumin, a natural polyphenolic hydrophobic product, is extracted from the rhizomes of Curcuma longa. It has various medicinal properties including antioxidant and anti-inflammatory, antimicrobial, antifungal, antiviral and antiangiogenic, anticancer, and antiatherosclerotic effects [4][5][6][7][8][9][10][11].…”

Preparation, Physicochemical Assessment and the Antimicrobial Action of Hydroxyapatite–Gelatin/Curcumin Nanofibrous Composites as a Dental Biomaterial

“…Curcumin (diferuloylmethane) is achieved from the Curcuma longa (Turmeric) rhizome. Lately, it has received important attention as a medicinal plant owing to its distinctive therapeutic benefits including antimicrobial, anti-pathogenic, antioxidant and anti-inflammatory, anti-angiogenic, anticancer, and anti-diabetic effects [ 9 , 10 , 11 , 12 ]. Despite its outstanding biological effects, there are limitations to its clinical use owing to its low bioavailability.…”