Sistema ABO e formas anatomoclínicas da doença de Chagas crônica

Teixeira, Vicente de Paula Antunes; Martins, Esmeralda; Almeida, Hipólito de Oliveira; Soares, Suellen; Souza, Hélio Moraes de; Morais, Cicílio Alves de

doi:10.1590/s0037-86821987000300007

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…A previous study in a small number of HIV-infected patients have shown that subjects with blood group B and also those who are Rh negative show decreased susceptibility to HIV infection [21]. Other infectious diseases, such as Chagas’ disease and dengue fever, have a more aggressive and symptomatic course in AB-group individuals [22, 23]. Infection with HTLV-1 has also been more frequently observed in blood group AB [24].…”

Section: Discussionmentioning

confidence: 99%

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Onsten¹,

Callegari-Jacques²,

Goldani³

2013

TOAIDJ

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Objective:To analyze the frequency of and odds for and against HIV infection based on ABO blood type in a large sample of blood donors.Background:Coevolution between pathogens and hosts may explain the ABO system of polymorphisms. HIV-infected cells add ABO(H) blood group antigens to the viral envelope. Naturally occurring antibodies against ABO(H) antigens that are present in normal human sera are able to neutralize ABO-expressing HIV in vitro. Blood donors are ideal for studying blood groups and HIV infection in vivo because all donors are routinely typed and tested.Methods:All blood donors who donated blood between 1994 and 2010 were tested for HIV (ELISA antibody tests and Western blot test or immunofluorescence testing) and were ABO typed (direct and reverse grouping tests). HIV infection based on the ABO blood group was analyzed using the chi-square test and game theory.Results:The total number of examined blood donors during this period was 271,410, of whom 389 were infected with HIV. B-group donors were more infected than non-B donors (p= 0.006).Conclusions:A more restricted antigen recognition capacity of anti-Galα1-3Gal in blood groups AB and B and a weaker antigen-binding capacity of anti-A antibodies may contribute to a higher frequency of HIV infection in blood group B.

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Section: Discussionmentioning

confidence: 99%

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Onsten¹,

Callegari-Jacques²,

Goldani³

2013

TOAIDJ

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“…The possibility exists, for instance, that cured chagasic patients of groups AB and B are immunotolerant to Galal-3 antigens, presenting lower levels of residual antilaminin antibodies. In fact, Teixeira et al (19) demonstrated that individuals of blood group O display less morbidity to T. cruzi infection than those of blood groups AB and B. In addition, the variation of anti-laminin titers within the groups (Table 3) may be explained by the heterogeneity of the patient blood groups.…”

Section: Discussionmentioning

confidence: 99%

Anti-Trypanosoma cruzi and anti-laminin antibodies in chagasic patients after specific treatment

et al. 1988

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The antibody response to Trypanosoma cruzi epimastigote and trypomastigote stages, as well as to laminin, was studied in several groups of chagasic patients. In six patients who were cured of the parasite, the serum antibody titers as revealed by indirect immunofluorescence and hemagglutination tests against epimastigotes (conventional serology) and a complement-mediated lysis test with living trypomastigotes did not differ from those of normal individuals. In seven presumably cured patients, although the complement-mediated lysis test turned negative, conventional serology remained positive. Sera from this group of so-called "dissociated" patients presented significant lower mean antibody titers against epimastigote but not trypomastigote stages than did sera from 14 untreated patients (P < 0.01). Most of the antibodies against trypomastigotes, including the residual levels found in cured patients, were absorbed by mouse laminin. In fact, significantly higher titers of anti-laminin antibodies were observed in sera from untreated chagasic patients (1.131 + 0.458) and cured patients (1.103 ± 0.572) than in sera from eight normal individuals (0.459 ± 0.402) (P < 0.01). The anti-laminin titers were higher in sera of patients of blood group A or O than in those of patients of group B or AB. In Western blotting (immunoblotting) analysis against trypomastigotes, sera from chronic untreated patients recognized many polypeptide bands ranging from 26 to 160 kilodaltons, whereas no protein bands were observed with sera from cured patients. Only faint bands of parasite proteins were observed with sera of dissociated patients. In conjunction, the above data suggest that the anti-trypomastigote antibodies which persist after parasitological cure of patients with Chagas' disease are due mainly to cross-reactive epitopes from mouse lamimn.

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“…[ 105 ]. In Brazil, the variants IL17A and IL17F are associated with the development of cardiomyopathy [ 106 ] In the African/African-American population, p.Arg514-Gly, a polymorphism of ACE2, is associated with cardiovascular and pulmonary conditions [ 107 ] In Genome-wide Association Study (GWAS) in Italian and Spanish hospitals, a 3p21.31 gene cluster encompassed the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1 genes [ 108 ] Genetic polymorphisms of Interferon-γ Production In the Brazilian population, genotypes and alleles of IL12B and IL-10 could be associated with a failure to regulate Th1 responses, IFNγ production, and an increased risk of chronic CD cardiomyopathy [ 109 ] Interferon-gamma gene (IFNG) + 874 T/A polymorphism could be related to a predisposition to CD in the South American population [ 110 ] The single nucleotide polymorphism (SNP) rs6598045 of the interferon-induced transmembrane protein 3 (IFITM3) gene correlates with COVID-19 fatality rates [ 111 ] Populations with a low allele frequency of rs1990760 (T allele) in IFIH1 (InterFeron-Induced Helicase 1; MDA5) are associated with less IFN-beta expression and potential susceptibility to COVID-19 infection [ 112 ] ABO blood group system Inconclusive studies found an increase in blood group B patients dying suddenly from CD [ 113 ] The histo-blood group system explored by GTA, GTB, FUT II, and FUT III glycosyltransferases found that B plus AB secretor phenotypes are related to megaesophagus and megacolon in CD [ 114 ] GWAS found blood group A is associated with COVID-19 and respiratory failure [ 111 ] Type A blood is associated with the risk of in-hospital death [ 115 ] Ethnicity CD with megacolon, calibre and length of the rectosigmoid depends on altitude, ethnicity, and diet [ 116 ] COVID-19 presents an increased risk depending on the population studied, e.g. Black and Asian compared to white subjects had increased risk infection of COVID-19 [ 117 ] In Mexico, native peoples have a higher risk of death due to COVID-19 [ 118 ] Dysregulated immunothrombosis Hypercoagulability The activation of haemostasis is related to the activation and increase of various molecules, e.g.…”

Section: Introductionmentioning

confidence: 99%

Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation

et al. 2021

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Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.

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Sistema ABO e formas anatomoclínicas da doença de Chagas crônica

Cited by 7 publications

References 5 publications

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Anti-Trypanosoma cruzi and anti-laminin antibodies in chagasic patients after specific treatment

Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation

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