Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation

Abstract

Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.

Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas Disease

“…This, alongside the limited knowledge of COVID-Chagas coinfection, has posed great challenges to counteracting multiple pandemics at once. Prevention programs for CD have been impaired to such an extent that there may be a reversal in progress [ 10 ]. COVID-19 and CD share more in terms of biological processes and pathophysiology.…”

Gestão Hospitalar Em Tempos De Pandemia: Um Relato De Experiência

“…A ligação do vírus à ECA2 promove também danos ao endotélio vascular, assim como a liberação de neuraminidases em razão da invasão pelo protozoário, estando altamente associadas à hipercoagulabilidade e à trombose. Ambas as patologias comungam de uma desregulação nos fatores de coagulação justificada por bases imunológicas: ao adentrar o organismo desencadeiam a ativação das respostas imunes inata e adquirida, culminando no crescimento das plaquetas séricas e na formação das NETs (redes extracelulares de neutrófilos), bem como uma suprarregulação de citocinas; monócitos; fibrinogênio; fator XII da cascata de coagulação, D-dímero e outros (PÉREZ-CAMPOS MAYORAL et al, 2021).…”

Re: “Immunothrombotic dysregulation in chagas disease and COVID‑19: a comparative study of anticoagulation”

“…We read with interest the recent article of Mayoral et al [ 1 ] “Immunothrombotic dysregulation in chagas disease and COVID‑19: a comparative study of anticoagulation”. First of all, we would like to point out to the authors that the correct spelling is “Chagas” disease, not “chagas” disease.…”