Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas Disease

Pradhan, Aishwarya Umesh; Uwishema, Olivier; Wellington, Jack; Nisingizwe, Philemon; Thambi, Vimala Devi; Onyeaka, Chinyere Vivian Patrick; Onyeaka, Helen

doi:10.1016/j.amsu.2022.104414

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…• Buruli ulcer • Chagas disease The NTDs are mainly diseases in developing countries, as shown in the maps of some of the NTDs down if compared to the map of poverty shown earlier in the chapter (Figure 6) [77][78][79][80][81][82][83][84]. However, due to a lack of funding, the WHO published a 2021 booklet as a road to end the NTDs by 2030 by integrating their prevention and control (Figure 7) [76].…”

Section: Neglected Tropical Diseases Related To Povertymentioning

confidence: 99%

Impact of Poverty on Health

Alqassim¹

2023

Healthcare Access - New Threats, New Approaches

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Poverty is not merely the absence of money but the absence of resources to get the necessities of life. Poverty and health are always in a reciprocal relationship. This relation came to light in 1948 when the WHO defined health as complete physical, mental and social wellbeing. In 1987, the Alma-Ata declaration opened the discussion on health inequity. This opened the door for thousands of projects, proposals, and publications on this relation. Although the relationship between poverty and infectious diseases was clear, there was inequity in funding. The Global Fund invests US$ 4 billion annually for AIDS, tuberculosis, and Malaria, while other diseases lack funds. That is why they were considered neglected tropical diseases. However, the relationship between health and poverty is not limited to infectious diseases but includes noninfectious problems like malnutrition and injuries. In this chapter, we will assess the association between poverty as a predictor and health as an outcome.

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Section: Neglected Tropical Diseases Related To Povertymentioning

confidence: 99%

Impact of Poverty on Health

Alqassim¹

2023

Healthcare Access - New Threats, New Approaches

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“…Providing appropriate well-equipped toilets and free immunisations for affected communities are effective solutions to contain HAV outbreaks [ 13 ]. Further emphasis should be put on the immunisation of vulnerable populations, like the elderly and those suffering from co-morbidities [ [33] , [34] , [35] ]. However, financial constraints and the need to prioritise health budgets put constraints on HAV vaccine administration.…”

Section: Recommendationsmentioning

confidence: 99%

Hepatitis A virus outbreak in Lebanon: Is it a matter of concern?

Uwishema

Abbass

Rai

et al. 2022

Annals of Medicine &Amp; Surgery

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“…As per the World Health Organization (WHO) reports there are more than 20 Neglected tropical diseases (NTDs) which contains several contagious illnesses of tropical and subtropical regions including Buruli ulcer, [1] chagas disease, [2] dengue, chikungunya, [3] dracunculiasis (guinea-worm disease), [4] echinococcosis, [5] foodborne trematodes, [6] human African trypanosomiasis (sleeping sickness), [7] leishmaniasis, [8] leprosy (Hansen's disease), [9] lymphatic filariasis etc. To combat NTDs, the WHO) has implemented five main management approaches: enhanced water and sanitation, vector control, increased disease management, preventative chemotherapy, and neglected zoonotic illnesses.…”

Section: Introductionmentioning

confidence: 99%

Alternative Approaches for the Treatment of Chagas Disease

Chaudhary,

Rajge,

Khandale

et al. 2024

ChemistrySelect

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Chagas disease (CD), or American trypanosomiasis, caused by the parasitic protozoa Trypanosoma cruzi, is a substantial global health burden. This comprehensive review explored the multifaceted landscape of CD treatment, providing a historical perspective on the development and discontinuation of benznidazole (BNZ) and nifurtimox (NF), the primary medications. Efforts towards a pediatric version of BZN in Brazil address demographic‐specific treatments, while concerns over drug resistance prompt the exploration of alternative medications like Amiodarone, Allopurinol, Posaconazole, Ravuconazole, and Fexinidazole, which were clinically tested as antichagasic drugs. In recent years, some of the synthesized derivative (1,3‐thiazoles, 4‐thiazolidinones, 2‐styrylquinolines, imidazole‐containing nitrophthalazine, and some others) were found to better activity as compared to standard drug. Traditional herbal alternatives (Resveratrol, curcumin, 1,8‐cineole, β‐pinene, and some others) rooted in traditional practices show promise, with various plant extracts exhibiting anti‐parasitic properties. The frontier of nanomedicine unfolds with studies on solid nanomedicines, PLA‐nanoparticles, ZIF‐8, BNZ carriers, and PLGA nanoparticles, showcasing improved drug delivery systems and controlled release mechanisms. The absence of a definitive vaccine accentuates ongoing research in recombinant antigens, peptide‐based vaccines, and nanoparticle formulations, with notable candidates like TcG1, TcG2, TcG4, MASPpep‐KLH, adenovirus vectors, Tc24 protein, and integrin activators. A novel strategy combining a recombinant protein vaccine with low dose BZN treatment presents promising results in a mouse model, emphasizing the urgency for further research and potential advancements in CD therapeutics.

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Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas Disease

Cited by 4 publications

References 22 publications

Impact of Poverty on Health

Impact of Poverty on Health

Hepatitis A virus outbreak in Lebanon: Is it a matter of concern?

Alternative Approaches for the Treatment of Chagas Disease

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