The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Onsten, Tor Gunnar Hugo; Callegari-Jacques, Sídia M.; Goldani, Luciano Zubaran

doi:10.2174/1874613601307010047

Cited by 16 publications

(26 citation statements)

References 24 publications

(26 reference statements)

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“…Thus, Zuckerman and McDonald [ 19 ] found an excess of group A and a corresponding deficit of group O in 378 cases of acute hepatitis during a probable outbreak of hepatitis B in the British Air Force. Moreover, a study conducted in 2013 on Brazilians infected with HIV [ 11 ] revealed that the highest proportion of people infected with HIV has been observed in those of blood group B. The lowest proportion was observed in groups A and O.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

ABO/Rh Blood Groups and Risk of HIV Infection and Hepatitis B among Blood Donors of Abidjan, Côte D’Ivoire

Siransy¹,

Nanga²,

Zaba³

et al. 2015

EuJMI

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Hepatitis B and HIV infection are two viral infections that represent real global public health problems. In order to improve their management, some hypotheses suggest that genetic predispositions like ABO and Rh blood groups would influence the occurrence of these diseases.The aim of the present study was to examine the association between ABO and Rhesus blood groups and the susceptibility to HIV infection and hepatitis B.We conducted a cross-sectional and analytical study in a population of voluntary blood donors in the Blood Transfusion Center of Abidjan. All blood donors who donated blood between January and June 2014 were tested for HBs antigen and anti-HIV antibodies (ELISA tests) and were ABO typed.The total number of examined blood donors during this period was 45,538, of which 0.32% and 8.07% were respectively infected with HIV and hepatitis B virus. O-group donors were more infected than non-O donors.Our study is an outline concerning the search for a link between ABO and Rh blood groups and hepatitis B and HIV infection. Further studies should be conducted to confirm the interaction between these two infections and contribute to the search for new therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

“…Blood donors are ideal for this purpose, as all donors are routinely subjected to ABO blood group antigen and antibody typing and laboratory tests to detect these two infections [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

ABO/Rh Blood Groups and Risk of HIV Infection and Hepatitis B among Blood Donors of Abidjan, Côte D’Ivoire

Siransy¹,

Nanga²,

Zaba³

et al. 2015

EuJMI

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“…These results suggest that ABO incompatibility at the time of primary virus exposure may offer some protection. Finally, a retrospective 16-year study of 271,000 Brazilian blood donors reported a slightly higher incidence of HIV among group B donors (286). Among the 389 HIV ϩ donors (0.01%) found upon screening, 14% were group B individuals, a rate which was slightly higher than that in the general population (9%; OR, 1.5 [95% CI, 1.13 to 2]).…”

Section: Hivmentioning

confidence: 95%

Blood Groups in Infection and Host Susceptibility

2015

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SUMMARY Blood group antigens represent polymorphic traits inherited among individuals and populations. At present, there are 34 recognized human blood groups and hundreds of individual blood group antigens and alleles. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. Blood groups can play a direct role in infection by serving as receptors and/or coreceptors for microorganisms, parasites, and viruses. In addition, many blood group antigens facilitate intracellular uptake, signal transduction, or adhesion through the organization of membrane microdomains. Several blood groups can modify the innate immune response to infection. Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures. Microorganisms can also stimulate antibodies against blood group antigens, including ABO, T, and Kell. Finally, there is a symbiotic relationship between blood group expression and maturation of the gastrointestinal microbiome.

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“…Abdulazeez et al [29] on the other hand, had reported that blood group AB individuals were more prone to HIV-1 than HIV-2 while HIV-1 prevalence was significantly higher among rhesus D positive subjects than their rhesus D negative counterparts. Another contradictory result was from Onsten et al [30] who reported a higher frequency of HIV infection in blood group B compared to non-B donors. On the other hand, Mohammadali and Pourfathollah [31] reported a significant association between HIV infection and blood group A.…”

Section: Resultsmentioning

confidence: 96%

Incidence of Vertical-Transmission of HIV and Its Correlation with Maternal Gestational Age at Antenatal Booking in Port-Harcourt, Nigeria

Buseri

Eze

Golden

2019

JAMMR

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Background: Pregnancy associated with human immunodeficiency virus (HIV)- infection poses risk to the fetus due to vertical-transmission. This can be prevented through administration of antiretroviral drugs. Our objective was to investigate the incidence of vertical-transmission of HIV and its correlation with maternal gestational age at antenatal booking with immediate commencement of antiretroviral therapy in Port-Harcourt, Nigeria. Methods: All antenatal attendees and their HIV-exposed newborns were screened for HIV-infection between April, 2016 and May, 2017 using qualitative rapid ELISA kits and HIV-DNA PCR technique. The HIV-positive antenatal attendees were placed on daily single-dose triple antiretroviral regimen (efavirenz, lamivudine, tenofovir, 600/300/300mg tablet) with multivitamins from the first day of booking and continued afterward. The HIV-exposed babies were placed on 5ml daily single-dose triple antiretroviral chemoprophylaxis on the first day of delivery and continued until blood collection at 6 weeks for HIV diagnosis. Statistical Package for Social Science (SPSS) software (version 17.0) was used for data analysis. Results: We found 4.34% overall prevalence of HIV-1 infection among the antenatal attendees and 7.57% incidence of mother-to-child transmission. There was significant difference between gestational age at booking with commencement of ART and the number of HIV-positive babies (χ2=7.113, df=2, P<0.05). There was no vertical transmission among the attendees who booked at first trimester, 35.7% at second trimester and 64.3% at third trimester. There was no statistically significant gender difference (P>0.05) between the number of infected males, 42.9% and females, 57.1%. Conclusion: High incidence of vertical-transmission of HIV was obtained from those HIV-positive mothers who registered late for antenatal care. Therefore, strong advocacy for early entry into antenatal care is solicited.

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The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Cited by 16 publications

References 24 publications

ABO/Rh Blood Groups and Risk of HIV Infection and Hepatitis B among Blood Donors of Abidjan, Côte D’Ivoire

ABO/Rh Blood Groups and Risk of HIV Infection and Hepatitis B among Blood Donors of Abidjan, Côte D’Ivoire

Blood Groups in Infection and Host Susceptibility

Incidence of Vertical-Transmission of HIV and Its Correlation with Maternal Gestational Age at Antenatal Booking in Port-Harcourt, Nigeria

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