2011
DOI: 10.1590/s0100-40422011000100015
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Abstract: , 50670-901 Recife -PE, BrasilRecebido em 12/2/10; aceito em 6/7/10; publicado na web em 16/11/10 SYNTHESIS AND PRELIMINARY EVALUATION OF ANTINOCICEPTIVE ACTIVITY OF NOVEL ISOXAZOLYL-ARYL-HYDRAZONES. New 2-isoxazoline aldehydes were synthesized, in good yields, from cycloadduct of the 1,3-dipolar cycloaddition reaction between endocyclic enecarbamate and carboethoxyformonitrile oxide (CEFNO). Condensation of these 2-isoxazoline aldehydes with several phenyl-hydrazines produced new isoxazolyl-aryl-hydrazones, w… Show more

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Cited by 6 publications
(2 citation statements)
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References 11 publications
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“…The azomethine proton (-NHNACH-) formed is an important source for new drug development (9). In recent years, the hydrazones have received considerable attention for displaying a variety of biological activities, such as antituberculotic, antimicrobial (27), antitumor (28), analgesic (29), and anti-inflammatory (30) properties. Some of these compounds have been described as more efficient than standard antibiotics (27).…”
Section: Discussionmentioning
confidence: 99%
“…The azomethine proton (-NHNACH-) formed is an important source for new drug development (9). In recent years, the hydrazones have received considerable attention for displaying a variety of biological activities, such as antituberculotic, antimicrobial (27), antitumor (28), analgesic (29), and anti-inflammatory (30) properties. Some of these compounds have been described as more efficient than standard antibiotics (27).…”
Section: Discussionmentioning
confidence: 99%
“…Various other nitrogen‐containing five‐membered heterocyclic compounds such as triazole, [7–8] imidazole[1,2‐ a ]pyridine, [9–11] etc., have also been explored for their biological activity. Isoxazoline‐based molecules have attracted considerable attention because of their ability to generate various cyclic and acyclic compounds and diverse biological profiles such as anti‐inflammatory, [12] anticancer, [13] antifungal, [14] antibacterial, [15] antioxidant, [16] anti‐asthmatic, [17–18] antinociceptive, [19–20] hypoglycemic, [21] antimalarial, [22] antituberculosis, [23] and antithrombotic activity [24] . Some compounds with the isoxazoline pharmacophore are found to be highly active and recommended in drug discovery [6,25] such as roxifiban acetate ( 2 ) acting as glycoprotein IIb/IIIa antagonists, [26] ( S , R )‐3‐(4‐hydroxyphenyl)‐4,5‐dihydro‐5‐isoxazole acetic acid methyl ester (ISO‐1; 3 ) acting as an inhibitor of the proinflammatory cytokine MIF, [27–28] and glucose‐based spiro‐isoxazolines 4 acting as antidiabetic compounds [21] .…”
Section: Introductionmentioning
confidence: 99%