The clinical treatment of wounds
with medical cotton gauze often
encounters inflammation and excessive immune response triggered by
bacterial infections, which can significantly prolong the wound healing
process. It is, therefore, of great significance to develop functional
gauzes with broad-spectrum antibacterial and anti-inflammatory activities.
Herein, we report a convenient, robust, and practical strategy to
functionalize medical cotton gauze by covalently immobilizing plant-derived
gallic acids. The obtained GA@Gauze exhibits not only excellent biosafety
and washing durability but also broad-spectrum bacterial antiadhesion
and bactericidal activities. More importantly, in vivo experiments
confirm that GA@Gauze can effectively reduce the bacterial invasion
and regulate inflammatory responses, resulting in faster production
of collagen fibers and accelerated wound healing. Therefore, this
simple and powerful route has great potential for fabricating the
next-generation functional gauzes for clinical treatment of wounds.