A DNase-mimetic artificial enzyme for the eradication of drug-resistant bacterial biofilm infections

Abstract

The construction of multifunctional nano-enzymes is a feasible strategy for fighting multi-drug resistant (MDR) bacterial biofilm-associated infections. Extracellular DNA (eDNA) is an important functional part of biofilm formation, including the...

Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle

“…To date, targeted eDNA technology is no longer limited to DNase. Bing et al designed an eDNAase-simulated artificial enzyme based on graphene-oxide-based naturalistic acid–cerium (IV) composite (GO-NTA-Ce) ( Figure 7 a) [ 150 ]. Qu et al also designed cerium (IV) complexes (eDNAase mimics) for targeting and hydrolyzing eDNA in biofilm [ 151 ].…”

Poly(oxanorbornene)s bearing triphenylphosphonium and PEGylated zinc(ii) phthalocyanine with boosted photobiological activity and singlet oxygen generation

“…Therefore, the scientific community has been performing studies to develop new methods and antibacterial agents against bacterial drug resistance in recent years. [1][2][3][4][5] The development of new antibacterial agents which are effective against drug-resistant bacterial infections requires new molecular targets and antibacterial strategies. 6 In this sense, amphiphilic poly(oxanorbornene)s are important molecular platforms used in the development of antibacterial materials.…”

Orthogonal light-triggered multiple effects based on photochromic nanoparticles for DNA cleavage and beyond

“…In contrast, irreparable DNA damage can induce apoptosis of cells and even cause pathological changes. [2][3][4] In view of the negative effect of DNA damage on cells, the controllable cleavage of the DNA of pathogenic cells is regarded as a promising method for disease treatment, such as cancer treatment, [5][6][7][8] antibacterial infections, [9][10][11][12] etc. Nucleases (e.g.…”