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Inflammation and thrombosis are two major complications of blood-contacting catheters that are used as extracorporeal circuits for hemodialysis and life-support systems. In clinical applications, complications can lead to increased mortality and morbidity rates. In this work, a biomimetic erythrocyte membrane zwitterion coating based on poly(2-methacryloyloxyethyl phosphorylcholine-co-dopamine methacrylate) (pMPCDA) copolymers is uniformly and robustly modified onto a polyvinyl chloride (PVC) catheter via mussel-inspired surface chemistry. The zwitterionic pMPCDA coating exhibits excellent antifouling activity and resists bacterial adhesion, fibrinogen adsorption, and platelet adhesion/activation. The material also demonstrates great hemocompatibility, cytocompatibility, and anticoagulation properties in vitro. Additionally, this biocompatible pMPCDA coating reduces in vivo foreign-body reactions by mitigating inflammatory response and collagen capsule formation, due to its outstanding ability to resist nonspecific protein adsorption. More importantly, when compared with a bare PVC catheter, the pMPCDA coating exhibits outstanding antithrombotic properties when tested in an ex vivo rabbit perfusion model. Thus, it is envisioned that this biomimetic erythrocyte membrane surface strategy will provide a promising way to mitigate inflammation and thrombosis caused by the use of blood-contacting catheters.

Antibacterial wound dressing is essential for inflammation control and accelerated wound healing. This study investigates polyzwitterion-functionalized silver nanoparticles (AgNPs) with enhanced antibacterial performance in an injectable wound dressing hydrogel. A...

The clinical treatment of wounds with medical cotton gauze often encounters inflammation and excessive immune response triggered by bacterial infections, which can significantly prolong the wound healing process. It is, therefore, of great significance to develop functional gauzes with broad-spectrum antibacterial and anti-inflammatory activities. Herein, we report a convenient, robust, and practical strategy to functionalize medical cotton gauze by covalently immobilizing plant-derived gallic acids. The obtained GA@Gauze exhibits not only excellent biosafety and washing durability but also broad-spectrum bacterial antiadhesion and bactericidal activities. More importantly, in vivo experiments confirm that GA@Gauze can effectively reduce the bacterial invasion and regulate inflammatory responses, resulting in faster production of collagen fibers and accelerated wound healing. Therefore, this simple and powerful route has great potential for fabricating the next-generation functional gauzes for clinical treatment of wounds.

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