A Uniform and Robust Bioinspired Zwitterion Coating for Use in Blood‐Contacting Catheters with Improved Anti‐Inflammatory and Antithrombotic Properties
Abstract:Inflammation and thrombosis are two major complications of blood-contacting catheters that are used as extracorporeal circuits for hemodialysis and life-support systems. In clinical applications, complications can lead to increased mortality and morbidity rates. In this work, a biomimetic erythrocyte membrane zwitterion coating based on poly(2-methacryloyloxyethyl phosphorylcholine-co-dopamine methacrylate) (pMPCDA) copolymers is uniformly and robustly modified onto a polyvinyl chloride (PVC) catheter via muss… Show more
“…This method involves a simple synthetic principle and can couple various antibacterial substances, drugs, and biomolecules to achieve surface functionalization through various click reactions, allowing more diverse applications of hydrogel coatings. Liu prepared a polymer zwitterion coating based on poly(2-methacryloyloxyethylphosphorylcholine-co-dopamine methacrylate) (pMPCDA) copolymers with anti-inflammatory and antithrombotic properties [52], which are also used for blood-contacting catheters. In order to prepare such a uniform and stable coating, the PVC surface was amino functionalized by co-deposition of polydopamine (PDA) and polyvinyl imine.…”
Section: Introduction Of Catechol Groups On the Substrate Surfacementioning
Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.
“…This method involves a simple synthetic principle and can couple various antibacterial substances, drugs, and biomolecules to achieve surface functionalization through various click reactions, allowing more diverse applications of hydrogel coatings. Liu prepared a polymer zwitterion coating based on poly(2-methacryloyloxyethylphosphorylcholine-co-dopamine methacrylate) (pMPCDA) copolymers with anti-inflammatory and antithrombotic properties [52], which are also used for blood-contacting catheters. In order to prepare such a uniform and stable coating, the PVC surface was amino functionalized by co-deposition of polydopamine (PDA) and polyvinyl imine.…”
Section: Introduction Of Catechol Groups On the Substrate Surfacementioning
Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.
“…Currently, in vitro antibacterial and animal models 79,87,88 of hydrogel coatings have been described, but their usage in clinical trials is rarely mentioned. An infection rate and cost analysis of UTIs with coated and un-coated catheters showed a 45% reduction in catheter-associated infections and lower cost in patients who use silver hydrogel catheters.…”
Section: The Clinical Application Of Hydrogel-coated Urethral Cathetersmentioning
Catheters are commonly used in hospital treatment, but most of the medical materials used in the production of catheters are hydrophobic, with high surface friction and weak antibacterial properties, so a large amount of money is spent on the treatment of catheter-related urinary tract infections worldwide every year. To improve the comfort of patients, weaken the friction and damage between urinary catheters and urethra, and reduce economic burden, coating the urethral catheter surface is a good strategy. Because of the softness, lubricity and functional network structure (load or graft different substances) of hydrogel, it has a wide range of applications for medical devices. In recent years, the studies of hydrogel coatings in urethral catheters have received more and more attention. This review mainly summarized the research progress of hydrogel coating in recent years, including its function and the method of guiding the grafting of hydrogel to the substrate, and the prospects in the future.
“…[62][63][64] In addition to their anticoagulant functions, zwitterionic coatings can act as anti-inflammatory agents by avoiding macrophage recognition and blocking the adhesion of inflammation-associated proteins. 57,65 In the development of such coatings, there are three essential points to be considered: the adequate coverage of the coating on the device surface, overall electrical neutrality of the zwitterionic groups, and formation of a bound water layer on highly hydrated surfaces. 66,67 Zwitterionic coatings also have inherent disadvantages; the polar interaction between the zwitterionic part and the surrounding aqueous medium (i.e., blood) reduces the stability of the coating, especially its mechanical properties.…”
Section: Zwitterionic Coatingsmentioning
confidence: 99%
“…66,67 Zwitterionic coatings also have inherent disadvantages; the polar interaction between the zwitterionic part and the surrounding aqueous medium (i.e., blood) reduces the stability of the coating, especially its mechanical properties. 57 The main methods used to increase the mechanical strength of the coating include pre-treating the device, adding bridging molecules between the device and the zwitterionic layer and increasing the mechanical strength inside the zwitterionic coating. Liu et al first achieved the amino-functionalisation of a poly(vinylchloride) (PVC) surface by co-depositing polydopamine (PDA) and polyethyleneimine (PEI) to provide uniform and stable substrate conditions for zwitterionic polymers.…”
Section: Zwitterionic Coatingsmentioning
confidence: 99%
“…Zwitterionic coatings are inspired by the external surfaces of mammalian erythrocyte membranes, which are rich in phospholipids and have zwitterion head groups with innate antifouling and anticoagulant abilities. 57 Zwitterionic ionic groups are crucial in zwitterionic coatings due to their anticoagulant function, which have equal amounts of positive and negative charges on the same side chain of the group. Equal and opposite charges attract water molecules through electrostatic interactions, forming a strong hydration layer that inhibits anti-nonspecific protein adhesion.…”
Extracorporeal membrane oxygenation (ECMO) is an invasive and last-resort treatment for circulatory and respiratory failure. Prolonged ECMO support can disrupt the coagulation and anticoagulation systems in a patient, leading to...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.