Serum uric acid is associated with quantitative ultrasound parameters in men: data from the Camargo cohort

Hernández, José L.; Nan, Daniel; Martínez, Josefina; Pariente, Emilio; Sierra, Isabel; González‐Macías, Jesús; Olmos, José M.

doi:10.1007/s00198-015-3083-4

Cited by 11 publications

(8 citation statements)

References 33 publications

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“…In 2011, Nabipour et al12 first reported that high serum UA concentrations were associated with high BMD values at all sites, including LS, TH, FN and WB, in a population-based cohort of 1,705 older men (aged ≥70 years). A recent study on 868 men older than 50 years showed that the BMD at LS, FN and TH was significantly higher in men with higher serum UA levels 15. In Chinese males with diabetes mellitus (54.14±11.49 years), higher serum UA was positively associated with higher BMD at all sites 16.…”

Section: Discussionmentioning

confidence: 94%

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Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Xiao¹,

Chen²,

Feng³

et al. 2017

CIA

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ObjectivesWe aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age.MethodsA cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites.ResultsSerum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA.ConclusionOur results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age.

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Section: Discussionmentioning

confidence: 94%

“…Many studies12,15–17 noticed a protective effect of UA on BMD at all sites, or only at LS. In 2011, Nabipour et al12 first reported that high serum UA concentrations were associated with high BMD values at all sites, including LS, TH, FN and WB, in a population-based cohort of 1,705 older men (aged ≥70 years).…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Xiao¹,

Chen²,

Feng³

et al. 2017

CIA

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“…Among 32 studies, 21 28 29 30 31 32 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 and 11 23 24 25 26 27 60 61 62 63 64 65 considered VIT D and SUA as the outcome, respectively. Within the 21 studies with VIT D outcome, 6 31 32 44 48 49 50 provided data of SUA and VIT D levels as continuous variables, 14 28 29 30 31 32 45 46 47 49 52 53 54 57 59 assessed association between SUA level as continuous data and categorical VIT D status, while 3 55 56 58 provided categorical data for both.…”

Section: Resultsmentioning

confidence: 99%

“…Within the 21 studies with VIT D outcome, 6 31 32 44 48 49 50 provided data of SUA and VIT D levels as continuous variables, 14 28 29 30 31 32 45 46 47 49 52 53 54 57 59 assessed association between SUA level as continuous data and categorical VIT D status, while 3 55 56 58 provided categorical data for both. For the 11 studies with SUA outcome, 1 64 had continuous data for both VIT D and SUA levels, 9 23 24 25 27 60 61 62 63 65 provided continuous data for VIT D level and categorical SUA status, and 2 25 26 provided categorical data for both.…”

Section: Resultsmentioning

confidence: 99%

“…Most of them(23) were crosssectional studies. Their participants were either from the general population or had specific diseases, with mean age ranging from 36.9 to 76.9 years.Among 32 studies, 21[28][29][30][31][32][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] and 11[23][24][25][26][27][60][61][62][63][64][65] considered VIT D and SUA as the outcome, respectively. Within the 21 studies with VIT D outcome, 6[31,32,44,[48][49][50] provided data of SUA and VIT D levels as continuous variables, 14…”

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Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

et al. 2020

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Association between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin D and serum uric acid, extracted the data, and conducted analysis by direct and network meta-analysis. The present review included 32 studies, of which 21 had vitamin D as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3 studies of 0.512 (95% confidence interval: 0.199, 0.825) and a significant pooled odds ratio between vitamin D deficiency and hyperuricemia of 1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups with hyperuricemia and normouricemia was non-significant at 0.138 (−0.430, 0.707) ng/ml, and the pooled mean difference of serum uric acid between categories of 25(OH)D were also non-significant at 0.072 (−0.153, 0.298) mg/dl between deficiency and normal, 0.038 (−0.216, 0.292) mg/dl between insufficiency and normal, and 0.034 (−0.216, 0.283) mg/dl between deficiency and insufficiency. In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study.

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Serum Uric Acid and Biomarkers of Lumbar Spine Bone Mineral Density

Yang¹,

Ishii

2017

Biomarkers in Bone Disease

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Serum uric acid is associated with quantitative ultrasound parameters in men: data from the Camargo cohort

Abstract: Higher serum uric acid levels in men older than 50 years are positively associated with QUS parameters. These data might suggest a better bone quality in men with elevated serum uric acid values.

Cited by 11 publications

References 33 publications

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

Serum Uric Acid and Biomarkers of Lumbar Spine Bone Mineral Density

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