Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Xiao, Jing; Chen, Weijun; Feng, Xiaogang; Liu, Wenyi; Zhang, Zhenxing; He, Li; Ye, Zhibin

doi:10.2147/cia.s130690

Cited by 25 publications

(22 citation statements)

References 17 publications

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“…In this line, similar results were those reported by Ishii et al (sample: n = 615) [14] and more recently by Yan et al (sample: n = 4256) [15]. In particular, in the latter study SUA was found to be positively correlated with BMD also in males (sample: n = 943) and associations with similar strengths and direction were reported in two other studies dealing with male subjects [25,26].…”

Section: Discussionsupporting

confidence: 91%

Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition

Bonaccorsi

Trentini

Greco

et al. 2019

IJMS

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Despite convincing experimental evidence, epidemiological studies on the effects of serum uric acid (SUA) on bone health are still conflicting since factors influencing SUA bioavailability have not been adequately considered. To shed some light on this issue, we investigated the impact of adiposity and menopause status on the relationship between SUA and bone health. We examined SUA in relation to bone mineral density (BMD) at different skeletal sites and with markers of bone metabolism in 124 pre-menopausal and 234 post-menopausal women and assessed whether adiposity, evaluated by anthropometry and dual x-ray absorptiometry (DXA), might have a discriminant role. After conservative adjustment (covariates: age, hormones treatment, smoking and time since menopause), SUA showed a significant and positive association with total hip BMD (β = 0.220, p < 0.01) among postmenopausal women, maintained also after adjustment for legs adiposity. Notably, stratification for waist circumference quartiles revealed that the correlation between SUA and total hip BMD was significant (r = 0.444, p = 0.001) in the highest quartile (91–100 cm). Our results suggest that SUA might be beneficial for bone health in postmenopausal women being characterized by a more android fat distribution, ascribing to SUA a discriminant role during menopause transition, potentially relevant also for men.

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Section: Discussionsupporting

confidence: 91%

Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition

Bonaccorsi

Trentini

Greco

et al. 2019

IJMS

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“… 44 Furthermore, in another recently published study by Xiao et al, serum UA levels were positively correlated with lumbar spine BMD and T-values in Chinese Han males (n=385) aged >50 years, suggesting the protective effect of UA on bone density at the lumbar spine. 45 …”

Section: Discussionmentioning

confidence: 99%

Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population

Kaushal¹,

Vohora²,

Jalali³

et al. 2018

TCRM

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PurposeOxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Reactive oxygen species are reported to suppress osteoblast generation and differentiation and enhance osteoclast development and activity. Increasing evidence suggests favorable effect of serum uric acid (UA) on bone metabolism due to its antioxidant properties. Therefore, we investigated the association between serum UA levels and bone mineral density (BMD) in healthy adult Indian subjects.Materials and methodsWe reviewed the medical records of 524 subjects who had undergone preventive health check-ups in a tertiary care hospital that included UA and BMD measurements at femur neck, total femur, and lumbar spine. Subjects concomitantly taking drugs or having a medical condition that would affect the bone metabolism or UA levels were excluded.ResultsThe final analysis included 310 subjects (mean age: 47.2±12.2 years; females: 43.5%; males: 56.5%). Study population was categorized into two groups based on the group median value for UA (ie, 5.4 mg/dL). BMD was significantly higher at all skeletal sites in subjects with UA >5.4 mg/dL compared to subjects with UA ≤5.4 mg/dL (p<0.001). On correlation analysis, UA was positively associated with BMD at all skeletal sites (r=0.211–0.277; p<0.05). The correlation remained significant after controlling for age (p<0.05) and lifestyle factors (smoking, alcohol use, physical activity, and diet; p<0.05) independently. UA significantly (p<0.001) accounted for 4.5%–7.7% of the variance in BMD (r2=0.045–0.077) in unadjusted model and 1.6%–3.2% of the variance (p<0.05) when adjusted for age and body mass index combined at lumbar spine and right femur neck, respectively.ConclusionWe conclude that raised UA levels are associated with higher BMD at all skeletal sites and UA may have a protective role in bone metabolism owing to its antioxidant effect.

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“…That might be another reason why risk of bone loss in these patients did not increase. A protective effect of uric acid (UA) on lumbar spine BMD has been reported in male patients [36] and hypothesized its potent antioxidant effect or via its interaction with the vitamin D/parathyroid hormone pathway [37], but high levels of serum UA (sUA) could cause oxidative stress and microinflammation as a pro-oxidant [38]; the role that high sUA/gout plays in OPF is also paradoxical [39][40][41]. In our study, likewise, hyperuricemia showed a positive effect on OP.…”

Section: Prevalence Of Bone Loss and Odd Ratiosmentioning

confidence: 99%

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

et al. 2020

BMC Musculoskelet Disord

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Backgroud: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients. Method: A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression. Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P < 0.001) and SLE (39.6%, P = 0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P < 0.001), OA (P = 0.02) and SLE (P = 0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of 'score below the expected range for age', osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors. Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

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Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Cited by 25 publications

References 17 publications

Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition

Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition

Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

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