Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population

Kaushal, Neelam; Vohora, Divya; Jalali, Rajinder K.; Jha, Sujeet

doi:10.2147/tcrm.s147696

Cited by 19 publications

(15 citation statements)

References 45 publications

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“…The study also confirmed no significant association between SUA and total body BMD in young adults, women, non-obese, and smokers. This finding is supported by several epidemiological studies using different study designs and population samples (23,24,(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) as listed in Table 2. These epidemiological studies aimed to elucidate the relation between SUA and bone health.…”

Section: Discussionsupporting

confidence: 64%

“…These epidemiological studies aimed to elucidate the relation between SUA and bone health. Many cross-sectional studies have confirmed the positive association between SUA and BMD in both genders and all age groups after adjustment for potential confounders (28,36,38). In other cross-sectional studies, the positive association was dependant on a significant interaction of SUA level with age and vitamin C level (40), central adiposity, or obesity among postmenopausal women (23,24,26).…”

Section: Discussionmentioning

confidence: 92%

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Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

et al. 2021

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BackgroundOxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental studies couldn’t draw a clear conclusion on the relation between SUA and bone health. We aim to investigate the association between SUA and bone mineral density (BMD) at different skeletal sites among healthy Qataris.MethodologyA cross-sectional analysis including total-body and site-specific bone mineral density scores and other serological markers of 2981 healthy Qatari adults (36.4 ± 11.1 years) from the Qatar biobank database was conducted. The study participants were divided into quartiles based on the level of SUA, and the BMD was measured using dual-energy X-ray absorptiometry (DXA). Multiple regression analyses were applied to investigate the association between SUA and BMD adjusting for multiple confounding factors.ResultsHigh levels of SUA were significantly associated with the increased bone mineral density of the total body and at site-specific skeletal locations after adjusting for age and gender (p-value < 0.001). Further adjustment for body mass index (BMI), smoking, vitamin D, alkaline phosphatase, and estimated glomerular filtration rate (eGFR) levels attenuated the association but the association remained significant for individuals with high SUA levels (p-value ≤ 0.01).The association between SUA and BMD was not significant in non-obese, females, young adults, and smokers. However, no interaction was found between SUA and age, gender, BMI and smoking.ConclusionHigher SUA levels are associated with a high bone density among healthy Qatari adults. However, such observation demands further investigations to outline the underlying mechanisms.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 92%

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

et al. 2021

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“…The exact mechanism(s) by which all these events occur remains unclear [ 44 , 45 ]. This is to inform that the results for the correlation analysis between BMD and serum UA in a subset of this population have recently been published [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Kaushal

Vohora

Jalali

et al. 2018

Osteoporosis and Sarcopenia

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ObjectivesAn understanding of bone mineral density (BMD) pattern in a population is crucial for prevention and diagnosis of osteoporosis and management of its complications in later life. This study aimed to screen the bone health status and factors associated with osteoporosis in an apparently healthy Indian population.MethodsA retrospective review of medical records was done in a tertiary-care hospital for the subjects who had undergone preventive health-check-ups that included BMD measurements at femur-neck, total-femur, and lumbar-spine.ResultsWe evaluated 524 subjects (age, 50.0 ± 12.4 years) including 41.2% female and 58.8% male subjects. Osteoporosis was present in 6.9% subjects (female, 11.1%; male, 4.2%) and osteopenia in 34% subjects (female, 40.3%; male, 29.9%). Absolute BMD was higher in male subjects (P < 0.001) compared to female subjects at all bone sites. Prevalence of osteoporosis increased with age in female subjects, but not in male subjects. Osteoporosis rates in the age-groups of 30–39, 40–49, 50–59, 60–69, and ≥70 years were 3%, 3.4%, 14.3%, 18.6%, and 36.4%, respectively in female subjects while prevalence in male subjects was 0%, 4%, 6.5%, 4.3%, and 5.6%, respectively, at lumbar spine. Height (r = 0.234–0.358), weight (r = 0.305–0.388), body mass index (r = 0.143–0.285) and physical activity (r = 0.136–0.153) were positively; and alkaline phosphatase (r = −0.133 to −0.203) was negatively correlated with BMD (all P < 0.01) at all sites. These parameters retained significant correlation after controlling for age and sex. No correlation of serum 25-hydroxy-vitamin-D and calcium was noted with BMD (P > 0.05) at any site.ConclusionsFurther data on absolute BMD, T scores, and prevalence rates of osteoporosis/osteopenia on multiple bone sites have been presented in this article.

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“…In a study consisting of 310 healthy Indian participants, Kaushal et al (12) categorized indiviuals into two groups based on the uric acid levels and found that height, weight and body mass index (BMI) in the group with serum uric acid 5.4 mg/dL and above were statistically significantly higher compared to the group with serum uric acid below 5.4 mg/dL. They noted that alkaline phosphatase, 25 (OH) D, fasting blood glucose and hemoglobin A1c (HBA1c) levels were similar between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Postmenopozal kadınlarda ürik asit ile kemik mineral yoğunluğu arasındaki ilişkinin değerlendirilmesi: tek merkezli retrospektif çalışma

Dilekçi¹,

Dilekçi

2020

Journal of Health Sciences and Medicine

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Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population

Cited by 19 publications

References 45 publications

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Postmenopozal kadınlarda ürik asit ile kemik mineral yoğunluğu arasındaki ilişkinin değerlendirilmesi: tek merkezli retrospektif çalışma

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