Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

Abstract

Backgroud: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients. Method: A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression. Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P < 0.001) and SLE (39.6%, P = 0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P < 0.001), OA (P = 0.02) and SLE (P = 0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of 'score below the expected range for age', osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors. Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

The prevalence of osteoporosis in rheumatoid arthritis patient: a systematic review and meta-analysis

“…To investigate the effect of each study on the pooled prevalence, we conducted a sensitivity analysis in which pooled prevalence are estimated omitting one study at a time. The highest pooled prevalence (28.1%, 95%CI 24.4–31.8%) was obtained by omitting the study of Innala et al 3 and the lowest pooled prevalence (27.0%, 95%CI 23.3–30.7%) was obtained by omitting the study of Hu et al 43 .…”

Factors affecting the incidence of postoperative periprosthetic fractures following primary and revision hip arthroplasty: a systematic review and meta-analysis

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The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study

“…Multiple studies have consistently shown an elevated prevalence of OP 7,33 and an increased susceptibility to fragility fractures 8 in individuals diagnosed with SLE. These observational studies align with our findings from the MR analysis, which established a causal effect of SLE on OP.…”