Serum PAPP-A Levels at 10–14 Weeks of Gestation Are Altered in Women After Assisted Conception

In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies

“…Our study also found a statistically significant reduction in the PAPP-A concentration in hormonally stimulated IVF/ ICSI pregnancies compared with controls. This is in agreement with previous studies (10,11,(13)(14)(15)(16)(17). In spontaneous FET and HRT-FET pregnancies, the PAPP-A levels were reduced but did not reach statistical significance compared with controls.…”

“…Also, a functional delay in fetal and placental development and the higher risk of obstetric complications associated with ART can lead to changes in marker concentrations (15,19). Several studies have suggested that exogenous hormone treatment is the main reason for reduced PAPP-A levels (11,15,16,21). In our study, we found that PAPP-A levels were reduced in hormonally stimulated IVF/ICSI pregnancies, but we also found that PAPP-A levels were decreased in nonstimulated FET cycles.…”

“…Several studies have reported a higher FPR in the ART group even after adjustment for maternal age (10,11,14). Tul et al (16) found a higher FPR in pregnancies conceived after ICSI. Amor et al (11) found a higher FPR in both fresh and frozenthawed embryos, but only in hormonally stimulated pregnancies.…”

First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10–14 weeks of gestation

“…Table 2). Some studies have found decreased levels of maternal serum PAPP-A in IVF (10-12, 14, 16) and in ICSI (12,14). Other studies, however, showed no differences in median PAPP-A MoM between naturally conceived pregnancies and pregnancies after IVF (7,13,15) or after ICSI (7, 10, 15).…”

First‐trimester maternal serum ADAM12‐s and PAPP‐A levels are altered in pregnancies conceived after assisted reproduction techniques (ART)

“…4,[29][30][31][32][33] Some previous studies have also found decreased levels of PAPP-A in the subgroup of IVF pregnancies. 4,[30][31][32]34,35 In FET pregnancies, PAPP-A concentrations were unaffected when compared with those in the natural conception in several previous studies. 29,30,32,36 However, two previous studies showed that PAPP-A levels were decreased in FET pregnancies, but only in FET cycles accompanied by any hormonal treatment.…”