In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies

First‐trimester maternal serum ADAM12‐s and PAPP‐A levels are altered in pregnancies conceived after assisted reproduction techniques (ART)

“…4,[30][31][32]34,35 In FET pregnancies, PAPP-A concentrations were unaffected when compared with those in the natural conception in several previous studies. 29,30,32,36 However, two previous studies showed that PAPP-A levels were decreased in FET pregnancies, but only in FET cycles accompanied by any hormonal treatment. 4,33 There is also a study where PAPP-A level was decreased only in ICSI-FET cycles but not in IVF-FET cycles.…”

Validation of Correction Factors for Serum Markers for First-Trimester Down Syndrome Screening in Singleton Pregnancies Conceived with Assisted Reproduction

“…Most studies showed decreased PAPP-A levels in ART pregnancies combined with unaltered levels of fβ-hCG [9,13,14,16,17,20,21] increased fβ-HCG levels [12,22,23,24] or even decreased fβ-hCG levels [15,25]. Two studies reported only an increase in fβ-hCG levels [10,26], and some studies reported no changes in maternal serum values in ART pregnancies [11,18,19].…”

“…In ART pregnancies maternal serum marker levels change during the first trimester affecting the risk assessment for DS [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. Counseling for prenatal screening of women carrying an ART pregnancy is complicated due to contradictory reports in FTS performance in ART pregnancies.…”

“…Counseling for prenatal screening of women carrying an ART pregnancy is complicated due to contradictory reports in FTS performance in ART pregnancies. Several studies reported higher false-positive rate (FPR) compared to spontaneously conceived pregnancies [5,6,7,8,9,10,11], some studies found higher FPR even after correction for maternal age [12,13,14,15] and others reported similar FPR [16,17,18,19,20]. Whether the prevalence of fetal chromosomal abnormalities in ART pregnancies is different from naturally conceived pregnancies is however unclear.…”

In VitroFertilisation: Perinatal Risks and Early Childhood Outcomes

“…79,80 However, this increase in false-positive rate was not confirmed in a recent, smaller, study. 81 This may reflect the relative inaccuracy of ultrasound dating, with the precise dating available for IVF pregnancies being largely ignored. [82][83][84] Further larger studies will be required before recommendations for adjustment of risk calculations for IVF pregnancies can be made.…”