First‐trimester maternal serum ADAM12‐s and PAPP‐A levels are altered in pregnancies conceived after assisted reproduction techniques (ART)

Sahraravand, Maarit; Laitinen, Päivi; Järvelä, Ilkka Y.

doi:10.1002/pd.4764

Cited by 5 publications

(6 citation statements)

References 61 publications

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“…ADAM12, also named meltrin‐α, has been reported to be involved in fertilization, muscle development, and cardiac hypertrophy . Recent studies demonstrate ADAM12 is involved in invasion and metastasis of tumor .…”

Section: Introductionmentioning

confidence: 99%

The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice

Zhao

Ning

Xie

et al. 2019

Journal of Bone and Mineral Research

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Pamapimod (PAM) is a novel selective p38 mitogen‐activated protein (MAP) kinase inhibitor proved to be effective in rheumatoid arthritis in phase 2 clinical trial. However, its effect on osteoclast‐associated osteoporosis and the underlying mechanisms remain unclear. In this study, we showed that PAM suppressed receptor activator of nuclear factor‐κB ligand (RANKL)‐induced osteoclast formation via inhibition of p38 phosphorylation and subsequent c‐Fos and nuclear factor of activated T cells c1 (NFATc1) expression. In addition, the downregulated NFATc1 leads to reduced expression of its targeting gene disintegrin and metalloproteinase domain‐containing protein 12 (ADAM12), which was further proven to be critical for osteoclastic bone resorption. Therefore, we treated ovariectomized (OVX) mice with PAM and revealed a protective effect of PAM on osteoporosis in vivo. In conclusion, our results demonstrated PAM can prevent OVX‐induced bone loss through suppression of p38/NFATc1‐induced osteoclast formation and NFATc1/ADAM12‐associated bone resorption. © 2018 American Society for Bone and Mineral Research.

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Section: Introductionmentioning

confidence: 99%

The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice

Zhao

Ning

Xie

et al. 2019

Journal of Bone and Mineral Research

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“…A total of 27 studies have been identified (Table ). Of those, all considered IVF, 15 considered ICSI, and five reported data concerning IVF/ICSI together . In one case, the type of ART was not specified .…”

Section: Resultsmentioning

confidence: 99%

“…All the studies except Hui et al (2005a) presented data concerning free β ‐hCG and PAPP‐A. All except Anckaert et al , Hui et al (2005 b), Niemimaa et al , Sahraravand et al and Zhong et al presented data on NT (Tables a, b and c).…”

Section: Resultsmentioning

confidence: 99%

“…In the studies of Bellver et al , Cavoretto et al , Gjerris et al , Hui et al , Matillainen et al and Sahravavand et al , they considered separately fresh and frozen embryo. Pregnancies obtained from frozen–thawed embryo transfer were excluded in the descriptive and meta‐analysis where only fresh embryo data were considered except for Tul and co‐workers' study where frozen embryo data were included in the descriptive analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The following potential biases in the methodology of the studies included in the review were evaluated: different protocols of ART, characteristics and size of the population, ultrasound and laboratory methodology, large interval of study (from 2001 to 2016) with different correction factors and statistical approaches used for conversion of the measured raw values of free β ‐hCG and PAPP‐A to MoMs. Main characteristics of considered study are provided in Table …”

Section: Methodsmentioning

confidence: 99%

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Nuchal translucency measurement, freeβ-hCG and PAPP-A concentrations in IVF/ICSI pregnancies: systematic review and meta-analysis

et al. 2017

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So far, data on the effect of assisted reproductive technologies (ART) on the components of first trimester combined screening for Down syndrome are still controversial. A systematic search of the literature was performed in order to identify the effect of ART, particularly in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) with fresh embryo transfer, on the nuchal translucency, free beta-human chorionic gonadotrophin and pregnancy-associated plasma protein-A measurements. Moreover, a meta-analysis and a descriptive graphical representation of the ratios between ART and spontaneous pregnancies (controls) values of median of the multiple of median (m MoM) were performed. Free beta-human chorionic gonadotrophin test showed slightly higher values in the ICSI group than controls (RR = 1.09, 95%CI: 1.03-1.16) but not in the IVF group (RR = 1.03, 95%CI: 0.94-1.12). Pregnancy-associated plasma protein-A values for IVF/ICSI, IVF and ICSI showed lower values in comparison with controls (RR, 95%CI 0.85, 0.80-0.90; 0.82, 0.74-0.89 and 0.83, 0.79-0.86, respectively). The nuchal translucency measurement did not show any statistical differences between study groups (IVF and ICSI) and controls (RR = 1.00, 95%CI: 0.94-1.08 and RR = 1.01, 95%CI: 0.97-1.05, respectively). These results may be due to alterations in the placentation of ART pregnancies. Differentiating further subgroups of ART pregnancies may explain the differences in biomarker concentrations, in prenatal behavior and in obstetric outcomes between ART and spontaneous pregnancies. © 2017 John Wiley & Sons, Ltd.

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Maternal serum levels of angiogenic markers and markers of placentation in pregnancies conceived with fresh and vitrified-warmed blastocyst transfer

Reljič

Porović

2019

J Assist Reprod Genet

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The aim of the study was to compare the levels of angiogenic markers and markers of placentation between pregnancies conceived with fresh (ET) and vitrified-warmed blastocyst transfer (FET). Methods Women with singleton pregnancies resulting from fresh ET or FET during the period between 2013 and 2017 were included in this prospective observational study. Fresh ET was performed in a stimulated and FET in natural cycle. At 6-7 weeks of gestation, after ultrasound confirmation of a single gestational sac with a viable embryo, serum levels of free β-hCG, pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PIGF) and fms-like tyrosine kinase (sFlt-1) were measured. Data on the patients' characteristics, pregnancy complications and outcomes were collected from a questionnaire and National Perinatal Information System of Slovenia. Results Among 211 pregnancies, 126 were achieved with fresh ET and 85 with FET. There were no significant differences in perinatal outcome, pregnancy complication and PIGF level between the fresh ET and FET group. Women achieving pregnancy with FET had significant higher levels of free β-hCG (40.20 ± 30.62 IU/L vs. 28.74 ± 23.52, p = 0.002), PAPP-A (0.09 ± 0.06 vs. 0.06 ± 0.05 IU/L, p = 0.004) and sFlt-1 (596.19 ± 283.06 vs. 436.53 ± 248.23 pg/L, p < 0.0001) compared to women having conceived with fresh ET. There were no significant differences in the levels of evaluated biomarkers between patients with different pregnancy outcomes and complications. Conclusion Levels of angiogenic markers and markers of placentation differ between pregnancies achieved with fresh ET and FET which may reflect altered implantation and early placentation with some forms of assisted reproductive technologies.

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First‐trimester maternal serum ADAM12‐s and PAPP‐A levels are altered in pregnancies conceived after assisted reproduction techniques (ART)

Abstract: ADAM12-s and PAPP-A levels are altered in several subgroups of ART pregnancies. Larger studies are required to confirm these findings.

Cited by 5 publications

References 61 publications

The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice

The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice

Nuchal translucency measurement, freeβ-hCG and PAPP-A concentrations in IVF/ICSI pregnancies: systematic review and meta-analysis

Maternal serum levels of angiogenic markers and markers of placentation in pregnancies conceived with fresh and vitrified-warmed blastocyst transfer

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