Rubella Seroprevalence in Women with Bad Obstetric History

Hassan, Hala Mohamed Majeed

doi:10.19080/jojiv.2016.01.555560

Cited by 3 publications

(5 citation statements)

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“…Women with abnormal TSH demonstrated a higher mean value for angiopoietin (93.78 pg/ml) and IL-17 (125.81 pg/ml) than women with normal TSH as the mean value was 89.23 pg/ml for angiopoietin and 115.53 pg/ml for IL-17. However, the mean value of IL-6 was about the same for women with normal (23.14 pg/ml) and abnormal (23.16 pg/ml) TSH, Table (8). Angiopoietin mean value was higher in small size family (93.2 pg/ml) as compared to large size (>3 crowding index) family (86.29 pg/ml).…”

Section: Discussionmentioning

confidence: 88%

“…In addition, IL-17 mean value was higher in women with age of < 30 years (119.06 pg/ml, P>0.05) as compared to women with age of ≥30 years (115.41 pg/ml). However, IL-6 mean value was about the same in women with age of <30 (23.28 pg/ml, P>0.05) and those with age of ≥30 years (23.04 pg/ml), Table (8). Angiopoietin mean value was higher in rural women (91.72 pg/ml, P>0.05) as compared to urban women (88.9 pg/ml).…”

Section: Table 5 Mean Values Of Angiopoietin1 Il-6 and Il-17 In Women...mentioning

confidence: 87%

“…In addition, IL-6 mean value was higher in uneducated (24.16 pg/ml, P>0.05) than in educated (22.23 pg/ml) women. However, Angiopoietin mean value was higher in educated (91.5 pg/mL>0.05) as compared to uneducated (88.47 pg/ml) women, Table (8). Women with history of congenital anomalies demonstrated a high angiopoietin mean value (110 pg/ml, P>0.05) than those without (89.59 pg/ml).…”

Section: Table 5 Mean Values Of Angiopoietin1 Il-6 and Il-17 In Women...mentioning

confidence: 89%

“…Angiopoietin-1 plays a vital role in the development of vasculogenesis and angiogenesis in human placenta [7]. Previous studies performed in Iraq indicated a significant association between infections, autoantibodies induction and hormones and bad obstetric outcomes [8][9][10][11][12][13][14][15][16][17][18]. Thus this study was conducted to determine the association between IL-6, IL-17 and angiopoietin in women with BOH in relation to some infections, TPO, TGA, TSH, SES and demographic characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

2019

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Background: Bad obstetric history [BOH] is associated with microbiological infections and abnormal immunological responses.Study design: Descriptive Case Control Study.Aim: to determine the association of interleukin-6 (IL-6), interleukin-17 (IL-17) and angiopoietin with infectivity inn female within Bad obstetric history, in Kirkuk city, Iraq.Materials and method: The study included 547 Bad obstetric histories within Bad obstetric history and 291 female with normal pregnancy outcome. The test performed to detect IL-6, IL-17 and angiopoietin in 60 women with BOH, of them 20 were pregnant and 20 were non-pregnant at time of enrolment in the study. In addition, 20 female with inevitable abortion be included in the study. Also thee study included 28 women with normal pregnancy as control and 14 of them were pregnant and 14 were non-pregnant. Serological study carried out to determine IL-6, IL-17 and Angiopoietin using ELISA kits.Results: IL-17 significantly lower in parvovirus 19 acute infection. Angiopoietin was significantly lower in Toxoplasma gondii infected women, while IL-6 was significantly higher in acute rubella infection as compared to non-infected. Angiopoietin was significantly higher in women with positive TPO autoantibodies. Smoking, animal exposure and low haemoglobin (<11) were associated with decrease in IL-6, while IL-17 was significantly higher in women with history of animal exposure.Conclusion: IL-6, IL-17 and angiopoietin may be influenced by infections in women with BOH, however, this need to be evaluated in a large scale study.

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Section: Discussionmentioning

confidence: 88%

Section: Table 5 Mean Values Of Angiopoietin1 Il-6 and Il-17 In Women...mentioning

confidence: 87%

Section: Table 5 Mean Values Of Angiopoietin1 Il-6 and Il-17 In Women...mentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

2019

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“…Van Nguyen et al (2013) explain that the pregnant women that not received rubella vaccination, their fetuses or new born has a congenital cataract [34]. Additionally, there was a significant difference in rubella IgG seroprevalence between women with BOH and control [16], while other study not shows such significant difference [12]. Mahmood et al confirm that the seropositive results by ELISA are not specific or less significant because of the probability of false positive that may be as a result of infection with other microorganism [35].…”

Section: Methodsmentioning

confidence: 99%

Molecular Diagnosis of TORCH Infection of Pregnant Women in Iraq

Al-Taie

Abdullah²,

Al-Attar

2019

Int J Med Sci

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Background: TORCH complex (Toxoplasma gondii, others, Rubella virus, Cytomegalovirus, and Herpes simplex virus) infections in pregnant women may attribute to bad obstetric outcomes.Objective: To investigate the role of TORCH as an etiology of bad obstetric outcome using a molecular technique.Materials and Methods: The samples were collected from women with Bad Obstetric History attending clinics in Mosul and Baghdad hospitals in Iraq over a period from (15/4/2013) to (1/6/2014) and from (1/5/2017) to (1/11/2017). The women included in the study were with mean age of (26±6.1) years and a range of 22 to 39 years. Blood samples, throat and cervical swabs were collected from 300 women ELISA positive seroprevalence of TORCH for PCR testing.Results: DNA and RNA were extracted and Real-Time PCR indicates negative results for T.gondii, Rubella and HSV I&II, but were CMV positive in only four samples represented (1.3%) from total 300 positive samples in ELISA tests.Conclusion: ELISA test is considered as a preliminary and screening test for TORCH infections. Real Time PCR is an essential tool in the research laboratory. It has engendered wider acceptance than the conventional PCR due to its improved rapidity, sensitivity, reproducibility and the reduced risk of carry-over contamination

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Seroprevalence of Rubella IgG in Women of Reproductive Age Group in a Tertiary Care Teaching Hospital

Karunakaran¹,

Madhavan²,

Devadasan³

et al. 2022

J. Pure Appl. Microbiol.

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Rubella is a highly contagious infection caused by the rubella virus. Mothers who develop rubella early in pregnancy have a 90% chance of transmitting the infection to their unborn babies. Adverse effects on the fetus include stillbirth and congenital rubella syndrome. Pregnant women are not regularly screened for rubella antibodies in government hospitals in Kerala. Therefore, to raise awareness of healthcare providers, it is necessary to collect epidemiological data on the seroprevalence of rubella in this vulnerable group. Several sociodemographic variables as potential predictors of immunity to rubella were also analyzed. A cross-sectional descriptive study was conducted at Govt TD Medical College in Alappuzha, Kerala, of 604 women of childbearing potential who attended the Out patient department of the Obstetrics and gynecology division for the year from June 2016 to June 2017. Rubella-specific IgG (Quantitative) ELISA was done on patients after obtaining informed consent and filling out a questionnaire through direct interview. The test sera were considered seropositive (>15 IU/ml), seronegative (<13 IU/ml), or intermediate (13 -15 IU/ml) as per the manufacturer’s instructions. Rubella seroprevalence in the study group was found to be 73.3%. Around 26.65% were nonimmune to rubella infection. About 27.4% of antenatal cases in the present study were susceptible to rubella. The primigravidae had lower seroprevalence(28.5%) than multigravidae. The percentage of seropositivity was found to increase with age. Our observations show that women of childbearing age are highly susceptible to rubella. High seroprevalence without regular childhood vaccination indicates continued infection transmission of the rubella virus in the community. Hence there is a need for proper sero surveillance in this group who has not been vaccinated, before conception to eradicate CRS and Rubella.

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Rubella Seroprevalence in Women with Bad Obstetric History

Cited by 3 publications

References 0 publications

Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

Molecular Diagnosis of TORCH Infection of Pregnant Women in Iraq

Seroprevalence of Rubella IgG in Women of Reproductive Age Group in a Tertiary Care Teaching Hospital

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