Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

Abstract

Background: Bad obstetric history [BOH] is associated with microbiological infections and abnormal immunological responses.Study design: Descriptive Case Control Study.Aim: to determine the association of interleukin-6 (IL-6), interleukin-17 (IL-17) and angiopoietin with infectivity inn female within Bad obstetric history, in Kirkuk city, Iraq.Materials and method: The study included 547 Bad obstetric histories within Bad obstetric history and 291 female with normal pregnancy outcome. The test performed to detect IL-6, IL-17 and angiopoietin in 60 women with BOH, of them 20 were pregnant and 20 were non-pregnant at time of enrolment in the study. In addition, 20 female with inevitable abortion be included in the study. Also thee study included 28 women with normal pregnancy as control and 14 of them were pregnant and 14 were non-pregnant. Serological study carried out to determine IL-6, IL-17 and Angiopoietin using ELISA kits.Results: IL-17 significantly lower in parvovirus 19 acute infection. Angiopoietin was significantly lower in Toxoplasma gondii infected women, while IL-6 was significantly higher in acute rubella infection as compared to non-infected. Angiopoietin was significantly higher in women with positive TPO autoantibodies. Smoking, animal exposure and low haemoglobin (<11) were associated with decrease in IL-6, while IL-17 was significantly higher in women with history of animal exposure.Conclusion: IL-6, IL-17 and angiopoietin may be influenced by infections in women with BOH, however, this need to be evaluated in a large scale study.