Review of Recent Advances in Carbon Nanotube Biosensors Based on Field-Effect Transistors

Abstract

The extraordinary physiochemical properties of carbon nanotubes (CNTs) stimulated their wide application in biosensing research. Nanotube characteristics of fast electron transport, large surface area, high strength, excellent catalytic activity and good chemical stability contribute to ultrasensitive, highly selective and stable CNT biosensors. Among the various CNT biosensors, the field-effect transistor (FET) architecture has received tremendous attention due to the advantages of high performance, miniaturization, and capability for mass production. In this paper, we address recent advances in the development of CNT biosensors based on FETs. The synthesis and properties of CNTs are discussed, along with their integration into biosensors. Recent progress in device fabrication, including CNT functionalization, attachment, and bioreceptor immobilization in CNT-based FET biosensors are highlighted. Examples in medical, food and environmental fields are illustrated.

Carbon-Based Nanomaterials for Biomedical Applications: A Recent Study

“…On the basis of their target recognition and transduction mechanisms, these biosensors are largely categorized into electrochemical and electronic CNT-based biosensors and optical biosensors. CNTs have been renowned as promising materials for improving electron transfer, which makes them appropriate for combining electrochemical and electronic biosensors (Jacobs et al, 2010; Holzinger et al, 2014; Kumar et al, 2015; Wang et al, 2015; Yang et al, 2015; Hou et al, 2016; Zribi et al, 2016).…”

Graphene field-effect transistors as bioanalytical sensors: design, operation and performance

“…The discovery of low-dimensional semiconductors with extremely high surface-to-bulk ratios prompted the design of various highly-sensitive FET sensors for the detection of ions and molecules. 18,19 Among these, silicon nanowire FETs (Si-NWFETs) and carbon nanotube FETs (CNTFETs) have both been extensively demonstrated as bioanalytical sensors [20][21][22] and even ultimately miniaturized into single-molecule FETs with biomolecules. [23][24][25] Despite good sensing performance, the development of 1D-FETs remains hindered today by practical challenges in the synthesis, manipulation and scalable integration of 1D nanomaterials.…”

Role of nanoparticles in tackling COVID-19 pandemic: a bio-nanomedical approach

“…As carbon allotropes (graphite, diamonds, and amorphous carbon) exist, carbon nanotubes such as fullerene, graphene oxide, and graphene quantum dots are now becoming popular and highly regarded [44]. Carbon family member has inimitable characteristics and has been widely used in various biological applications including tissue engineering, biosensing, imaging, drug delivery, cancer therapy, and diagnosis [45,46].…”