Reference Values of Skin Autofluorescence

Koetsier, M.; Lutgers, Helen L.; Jonge, Charlotte de; Links, Thera P.; Smit, Andries J.; Graaff, Reindert

doi:10.1089/dia.2009.0113

Cited by 166 publications

(246 citation statements)

References 22 publications

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“…Because of these special fluorescent characteristics their accumulation on skin collagen can be estimated noninvasively using a skin autofluorescence (AFR) reader, also called an AGE reader [11]. Recent evidence has shown that AFR increases with age and is increased in patients with diabetes [12][13][14]. In COPD, it has been shown that CML is increased in epithelial lining fluid from peripheral airways as compared to healthy ex-and current smokers [15].…”

Section: Introductionmentioning

confidence: 99%

Plasma advanced glycation end-products and skin autofluorescence are increased in COPD

Gopal

Reynaert

Scheijen

et al. 2013

European Respiratory Journal

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Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and oxidative stress. These conditions may lead to the formation of advanced glycation end-products (AGEs).In this study we investigated in 88 COPD patients and 55 control subjects (80% ex-smokers) the association of the plasma protein-bound AGEs N e -(carboxymethyl)lysine (CML), pentosidine, N e -(carboxyethyl)lysine (CEL), and AGE accumulation in skin by skin autofluorescence (AFR), with lung function.Mean¡SD lysine and ex-smokers 27.7¡6.4 nmol?mmol -1 lysine) and AFR (COPD 3.33¡0.67 arbitrary units (AU), never-smokers 2.24¡0.45 AU and ex-smokers 2.31¡0.47 AU) were increased in COPD patients compared to controls. Disease state was inversely associated with CML, and linearly associated with CEL and AFR. Performing regression analyses in the total group, CEL and AFR showed a negative association and CML a positive association with lung function, even after correction for potential confounders.In conclusion, CEL and AFR were negatively and CML was positively associated with disease state. In the total group only the AGEs showed an association with forced expiratory volume in 1 s. Our data suggest that AGEs are involved in the pathophysiology of COPD, although their exact role remains to be determined. @ERSpublications Advanced glycation end-products are involved in the pathophysiology of COPD, but their exact role remains unknown

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Section: Introductionmentioning

confidence: 99%

Plasma advanced glycation end-products and skin autofluorescence are increased in COPD

Gopal

Reynaert

Scheijen

et al. 2013

European Respiratory Journal

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“…AF was lower in non-smokers than in smokers [11]. In persons with low skin reflectance (<10%), skin AF was dependent on skin colour, but was still related to age [12,13]. In our group, we did not find any connection of AGEs with smoking and also with age.…”

Section: Discussionmentioning

confidence: 46%

Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

Dina

Vladu

Dina

et al. 2012

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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“…Egészséges kaukázusi típusú kontrollszemélyekben mér-ve a SAF értéke az életkorral, kisebb mértékben a dohányzással mutatott összefüggést, a nemek között is találtak eltérést [33]. Erősebben pigmentált bőrű betegcsoportban a SAF értékei alacsonyabbak, kevésbé jelzik a diabeteses szövődményeket [34].…”

Section: A Bőr-autofl Uoreszcencia éRtékét Befolyásoló Tényezőkunclassified

A bőr-autofluoreszcencia és a konvencionális glykaemiás markerek kapcsolata diabeteses betegekben

et al. 2015

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Relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetesIntroduction: Skin autofl uorescence has a well-known signifi cance for screening diabetes and early diagnosis of vascular complications. It predicts cardiovascular events better than hemoglobin A1c, hence skin autofl uorescence is a marker of cumulative tissue glycemic load whereas hemoglobin A1c refl ects changes occurring in the previous 6-8 weeks. Aim: The aim of the authors was analyze the relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetes. Method: Skin autofl uorescence measurements were performed in 2010 in 18 patients (10 men and 8 women with normal glomerular fi ltration rate; age, 61.4±13.8 years) with long term follow-up (2624 months, 476 laboratory results). Relationships between skin autofl uorescence values and fasting blood glucose, hemoglobin A1c levels and metabolic parameters obtained before and after skin autofl uorescence measurements were analysed using Spearman rank test. Results: The average skin autofl uorescence value was 2.88±0.65 arbitrary units. There were no signifi cant correlations between skin autofl uorescence and hemoglobin A1c levels obtained before (7.84±1.08%, p = 0.07) and after the skin autofl uorescence measurements (7.45±1.18%, p = 0.71). Skin autofl uorescence values also failed to show relationship with fasting blood glucose obtained before (p = 0.09) and after (p = 0.29) the skin autofl uorescence measurements. Conclusions: In patients with diabetes skin autofl uorescence may provide novel information about glycemic burden. Skin autofl uorescence values (which may presumably provide a more accurate estimation of the cardiovascular risk) do not correlate with hemoglobin A1c and fasting blood glucose Keywords: skin autofl uorescence, hemoglobin A1c, cardiovascular riskMácsai, E., Rakk, E., Miléder, M., Fulcz, Á. [Relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetes]. Orv. Hetil., 2015, 156(33) EREDETI KÖZLEMÉNYRövidítések AGE = glikációs végtermékek; CABG = coronaria arteria bypass graft; CACS = coronaria arteria kalcifi kációs score; CGMS = (continuous glucose monitoring system) szövetiglü-kóz-szint monitorozása; CKD = krónikus veseelégtelenség; GFR = glomerulusfi ltrációs ráta; HbA 1c = hemoglobin-A-1c; IGT = csökkent glükóztolerancia; PAD = perifériás artériás betegség; RAGE = (receptor for AGE) glikációs végtermékek receptora; SAF = bőr-autofl uoreszcencia; T1DM = diabetes mellitus 1-es típus; T2DM = diabetes mellitus 2-es típus

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Reference Values of Skin Autofluorescence

Cited by 166 publications

References 22 publications

Plasma advanced glycation end-products and skin autofluorescence are increased in COPD

Plasma advanced glycation end-products and skin autofluorescence are increased in COPD

Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

A bőr-autofluoreszcencia és a konvencionális glykaemiás markerek kapcsolata diabeteses betegekben

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