Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

Dina, Raluca Costina; Vladu, Iulia; Dina, C.; Mitrea, Adina

doi:10.2478/v10255-012-0008-2

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…AGEs are glycated proteins, lipids, and nucleic acids that present with chronic exposure to hyperglycemia, inflammation, and oxidative stress [ 3 , 7 ]. AGEs are considered a marker of metabolic memory [ 5 , 8 ]. AGEs can accumulate in tissues through aging, dietary intake, and smoking.…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between micro-macrovascular complications and skin autofluorescence in patients with diabetes mellitus, renal failure, and cardiac diseases has been previously investigated [ 8 , 9 , 11 , 12 ], and SAF is an independent predictor of long-term cardiovascular complications. However, limited studies reported AGEs levels [ 13 – 15 ] or SAF [ 5 , 16 ] in patients with obesity. Body mass index (BMI) was found to be inversely correlated with SAF in patients with obesity [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, limited studies reported AGEs levels [ 13 – 15 ] or SAF [ 5 , 16 ] in patients with obesity. Body mass index (BMI) was found to be inversely correlated with SAF in patients with obesity [ 5 ]. Increased AGEs and decreased soluble AGE receptors were detected in patients with obesity [ 5 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Body mass index (BMI) was found to be inversely correlated with SAF in patients with obesity [ 5 ]. Increased AGEs and decreased soluble AGE receptors were detected in patients with obesity [ 5 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components

APAYDIN¹,

YAVUZ²

2022

Turkish Journal of Medical Sciences

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Background/aim Obesity, diabetes mellitus, and metabolic syndrome (MetS) are associated with increased accumulated skin advanced glycation end products. We aimed to evaluate the association of MetS components with skin autofluorescence (SAF) in patients with morbid obesity. Material and methods Eight hundred and one patients with morbid obesity and 94 age-matched controls with normal body mass index (BMI) and normal glucose metabolism were included. Advanced glycation end products (AGEs) were measured using SAF in the forearm, with an AGE reader. Results The prevalence of MetS in patients with morbid obesity was 65.5% (n = 525). Type 2 diabetes mellitus (type 2 DM) and hypertension were present in 40.9% (n = 328) and 43.7% (n = 357). Patients with morbid obesity and those with MetS had higher SAF measurements compared with the control group, 1.85 ± 0.44 arbitrary unit (AU) and 1.86 ± 0.43 AU vs. 1.72 ± 0.30 AU, respectively (p = 0.016). There was no difference in SAF levels between patients with and without MetS. SAF measurements of patients without MetS were not statistically different from the control group (p = 0.076). Patients with five MetS criteria had higher SAF measurements compared with patients with fewer MetS components (p = 0.019). There was no difference in SAF levels between patients with type 2 DM, impaired glucose metabolism, and patients with normal glucose metabolism (p = 0.513). Conclusion Although MetS and type 2 DM are known as factors related to increased SAF levels, obesity can cause elevated SAF measurements in different ways independent of concomitant comorbid diseases. Larger studies with longer follow-ups are needed to enlighten the underlying mechanism.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components

APAYDIN¹,

YAVUZ²

2022

Turkish Journal of Medical Sciences

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Atomic force microscopy investigation of the interaction of low-level laser irradiation of collagen thin films in correlation with fibroblast response

Stylianou

Yova

2015

Lasers Med Sci

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Low-level red laser (LLRL)-tissue interactions have a wide range of medical applications and are garnering increased attention. Although the positive effects of low-level laser therapy (LLLT) have frequently been reported and enhanced collagen accumulation has been identified as one of the most important mechanisms involved, little is known about LLRL-collagen interactions. In this study, we aimed to investigate the influence of LLRL irradiation on collagen, in correlation with fibroblast response. Atomic force microscopy (AFM) and fluorescence spectroscopy were used to characterize surfaces and identify conformational changes in collagen before and after LLRL irradiation. Irradiated and non-irradiated collagen thin films were used as culturing substrates to investigate fibroblast response with fluorescence microscopy. The results demonstrated that LLRL induced small alterations in fluorescence emission and had a negligible effect on the topography of collagen thin films. However, fibroblasts cultured on LLRL-irradiated collagen thin films responded to LRLL. The results of this study show for the first time the effect of LLRL irradiation on pure collagen. Although irradiation did not affect the nanotopography of collagen, it influenced cell behavior. The role of collagen appears to be crucial in the LLLT mechanism, and our results demonstrated that LLRL directly affects collagen and indirectly affects cell behavior.

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Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

Abstract: Background and Aim: Skin autofluorescence (AF) is a method used to detect the accumulation of Advanced Glycation End Products (AGEs)

Cited by 2 publications

References 14 publications

Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components

Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components

Atomic force microscopy investigation of the interaction of low-level laser irradiation of collagen thin films in correlation with fibroblast response

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