A bőr-autofluoreszcencia és a konvencionális glykaemiás markerek kapcsolata diabeteses betegekben

Abstract

Relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetesIntroduction: Skin autofl uorescence has a well-known signifi cance for screening diabetes and early diagnosis of vascular complications. It predicts cardiovascular events better than hemoglobin A1c, hence skin autofl uorescence is a marker of cumulative tissue glycemic load whereas hemoglobin A1c refl ects changes occurring in the previous 6-8 weeks. Aim: The aim of the authors was analyze the relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetes. Method: Skin autofl uorescence measurements were performed in 2010 in 18 patients (10 men and 8 women with normal glomerular fi ltration rate; age, 61.4±13.8 years) with long term follow-up (2624 months, 476 laboratory results). Relationships between skin autofl uorescence values and fasting blood glucose, hemoglobin A1c levels and metabolic parameters obtained before and after skin autofl uorescence measurements were analysed using Spearman rank test. Results: The average skin autofl uorescence value was 2.88±0.65 arbitrary units. There were no signifi cant correlations between skin autofl uorescence and hemoglobin A1c levels obtained before (7.84±1.08%, p = 0.07) and after the skin autofl uorescence measurements (7.45±1.18%, p = 0.71). Skin autofl uorescence values also failed to show relationship with fasting blood glucose obtained before (p = 0.09) and after (p = 0.29) the skin autofl uorescence measurements. Conclusions: In patients with diabetes skin autofl uorescence may provide novel information about glycemic burden. Skin autofl uorescence values (which may presumably provide a more accurate estimation of the cardiovascular risk) do not correlate with hemoglobin A1c and fasting blood glucose Keywords: skin autofl uorescence, hemoglobin A1c, cardiovascular riskMácsai, E., Rakk, E., Miléder, M., Fulcz, Á. [Relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetes]. Orv. Hetil., 2015, 156(33) EREDETI KÖZLEMÉNYRövidítések AGE = glikációs végtermékek; CABG = coronaria arteria bypass graft; CACS = coronaria arteria kalcifi kációs score; CGMS = (continuous glucose monitoring system) szövetiglü-kóz-szint monitorozása; CKD = krónikus veseelégtelenség; GFR = glomerulusfi ltrációs ráta; HbA 1c = hemoglobin-A-1c; IGT = csökkent glükóztolerancia; PAD = perifériás artériás betegség; RAGE = (receptor for AGE) glikációs végtermékek receptora; SAF = bőr-autofl uoreszcencia; T1DM = diabetes mellitus 1-es típus; T2DM = diabetes mellitus 2-es típus