Recent progress in the chemistry of non-monoterpenoid indole alkaloids

Effect of Rhaphidophora korthalsii methanol extract on human peripheral blood mononuclear cell (PBMC) proliferation and cytolytic activity toward HepG2

“…The cytotoxicity of the plant may be due to the presence of 5,6-dihydroxyindole (DHI), which showed the cytotoxic effect toward p388. (Toyota and Ihara, 1998). DHI also proved to have the cytotoxic effect on nonmelanocytic cancer cell but not melanocytic cell (Urabe et al, 1994).…”

Synthesis of Indoles through Highly Efficient Cascade Reactions of Sulfur Ylides and N‐(ortho‐Chloromethyl)aryl Amides

“…[1] Consequently, numerous efforts have been devoted to the development of efficient methods to construct the indole architecture. [1] Consequently, numerous efforts have been devoted to the development of efficient methods to construct the indole architecture.…”

“…With the optimal reaction conditions established ( Table 1, entry 8; 5.0 equiv Cs 2 CO 3 in xylenes at RT), we next investigated the substrate scope of the reaction by employing a variety of sulfur ylides (1). As summarized in Table 2, various sulfur ylides were found to participate in this cascade process.…”

Catalyst-free alkylation of aminopyrazole by isatin in water

“…A great number of compounds bearing oxindole moieties are reported to possess significant antibacterial, antiprotozoal, antiinflammatory and antitumor properties [6,7], and they have been widely employed as potential synthons for the synthesis of alkaloids, drug candidates and clinical pharmaceuticals [8][9][10]. Isatin-based alkylation is one of the most important strategies for the construction of oxindole skeleton, especially for those bearing a hydroxyl substituent at the C-3 position which also possess various bioactivities [11,12].…”