Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

Lemos, Janaína de Alcântara; Oliveira, Anna Eliza Maciel de Faria Mota; Araújo, Raquel Silva; Townsend, Danyelle M.; Ferreira, Lucas Antônio Miranda; Barros, André Luís Branco de

doi:10.1016/j.biopha.2021.112137

Cited by 15 publications

(8 citation statements)

References 186 publications

(201 reference statements)

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“…In this case, it was impossible to establish an optimal phytostimulant concentration or any encapsulation effect. However, encapsulation of this additive has many advantages, such as protection of the active agent, reduction in the amount of phytostimulant, and controlled release of the encapsulated molecule [ 69 , 70 ]. The amount of moisture in the seedlings growing in each mixture was higher than 80%, similar to that reported in the tests without phytostimulant ( Table 4 ) and on substrates with extracted eucalyptus fiber.…”

Section: Resultsmentioning

confidence: 99%

Extracted Eucalyptus globulus Bark Fiber as a Potential Substrate for Pinus radiata and Quillaja saponaria Germination

Ferrer-Villasmil,

Fuentealba,

Reyes-Contreras

et al. 2024

Plants

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This study aimed to explore alternative substrates for growing forest species using eucalyptus bark. It evaluated the potential of extracted Eucalyptus globulus fiber bark as a substitute for commercial growing media such as coconut fiber, moss, peat, and compost pine. We determined the physicochemical parameters of the growing media, the germination rate, and the mean fresh and dry weights of seedlings. We used the Munoo-Liisa Vitality Index (MLVI) test to evaluate the phytotoxicity of the bark alone and when mixed with commercial substrates. Generally, the best mixture for seed growth was 75% extracted eucalyptus bark fiber and 25% commercial substrates. In particular, the 75E-25P (peat) mixture is a promising substitute for seedling growth of Pinus radiata, achieving up to 3-times higher MLVI than the control peat alone. For Quillaja saponaria, the best growth substrate was the 50E-50C (coconut fiber) mixture, which had the most significant MLVI values (127%). We added chitosan and alginate-encapsulated fulvic acid phytostimulants to improve the performance of the substrate mixtures. The fulvic acid, encapsulated or not, significantly improved MLVI values in Q. saponaria species and P. radiata in concentrations between 0.05 and 0.1% w/v. This study suggests that mixtures with higher levels of extracted fiber are suitable for growing forest species, thus promoting the application of circular economy principles in forestry.

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Section: Resultsmentioning

confidence: 99%

Extracted Eucalyptus globulus Bark Fiber as a Potential Substrate for Pinus radiata and Quillaja saponaria Germination

Ferrer-Villasmil,

Fuentealba,

Reyes-Contreras

et al. 2024

Plants

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“…Numerous types of bioactive low-molecular weight metabolites present in plant latex such as alkaloids, flavonoids, have been effectively associated with nanomaterials ( Mehan et al., 2022 ). Several studies revealed that nanoencapsulation of pharmacologically active plant phytochemicals can increase the therapeutic efficiency in cancer treatment ( de Alcantara Lemos et al., 2021 ). Nano-formulatons are notably important for effective delivery of poorly soluble and low-bioavailable pharmaceuticals.…”

Section: Latex-bearing Plants and Nanotechnologymentioning

confidence: 99%

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Mazur

Bałdysz²,

Warowicka³

et al. 2022

Front. Plant Sci.

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Latex-bearing plants have been in the research spotlight for the past couple of decades. Since ancient times their extracts have been used in folk medicine to treat various illnesses. Currently they serve as promising candidates for cancer treatment. Up to date there have been several in vitro and in vivo studies related to the topic of cytotoxicity and anticancer activity of extracts from latex-bearing plants towards various cell types. The number of clinical studies still remains scarce, however, over the years the number is systematically increasing. To the best of our knowledge, the scientific community is still lacking in a recent review summarizing the research on the topic of cytotoxicity and anticancer activity of latex-bearing plant extracts. Therefore, the aim of this paper is to review the current knowledge on in vitro and in vivo studies, which focus on the cytotoxicity and anticancer activities of latex-bearing plants. The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. The cytotoxic effect of the plant’s crude latex, its fractions or isolated compounds, is analyzed, along with a study of cell apoptosis, chromatin condensation, DNA damage, changes in gene regulation and morphology changes, which can be observed in cell post plant extract addition. The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. It is solely based on the green-synthesis approach, which presents an interesting alternative to chemical-based nanoparticle synthesis. We have analyzed the cytotoxic effect of these particles on cells. Data regarding the cytotoxicity of such particles raises their potential to be involved in the design of novel cancer therapies, which further underlines the significance of latex-bearing plants in biotechnology. Throughout the course of this review, we concluded that plant latex is a rich source of many compounds, which can be further investigated and applied in the design of anticancer pharmaceuticals. The molecules, to which this cytotoxic effect can be attributed, include alkaloids, flavonoids, tannins, terpenoids, proteases, nucleases and many novel compounds, which still remain to be characterized. They have been studied extensively in both in vitro and in vivo studies, which provide an excellent starting point for their rapid transfer to clinical studies in the near future. The comprehensive study of molecules from latex-bearing plants can result in finding a promising alternative to several pharmaceuticals on the market and help unravel the molecular mode of action of latex-based preparations.

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“…Na área farmacêutica, o avanço da nanotecnologia é responsável por trazer muitas inovações no desenvolvimento de formulações com alto desempenho, como as nano e microemulsões (LOBÃO, 2011), que podem modificar profundamente a velocidade de liberação do princípio ativo, oferecendo benefícios que incluem o aumento da solubilidade, absorção e controle da biodisponibilidade de fármacos, alterando os parâmetros farmacocinéticos, diminuindo a toxicidade e aumentando a eficácia clínica dos medicamentos (FORMARIZ et al, 2005;LEMOS et al, 2021).…”

Section: Introductionunclassified

Caracterização de uma microemulsão contendo um derivado do dilapiol extraído de Piper aduncum (Piperaceae)

Barros

Pinto²,

Santos³

et al. 2023

PRW

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A nanotecnologia é uma inovação farmacêutica que visa veicular ativos em formulação microemulsinada com capacidade de liberar fármacos de forma modificada, uma alternativa para aplicação cutânea. O objetivo do estudo foi caracterizar uma microemulsão contendo um derivado de dilapiol (EBD) para administração tópica. Os componentes da formulação contendo o EBD (ME-EBD) foram padronizados, pesados e homogenizados por uma prancha agitadora em uma temperatura ambiente. A formulação foi analisada por Zetasizer Nano, para a centrifugação usou-se um tempo de 3 horas a 3500 rpm, na variação de temperatura avaliou de -4 ºC a 25 ºC. Foi obtido um diâmetro das partículas (45,1 nm), índice de polidispersão (0,286), condutividade (0,027 mS/cm) e potencial Zeta (-26,4 mV). Após a centrifugação não houve alterações significativas no diâmetro das partículas, assim como, nos ciclos alternados de gelo/degelo. A ME-EBD mostrou-se um sistema estável, de fase única, interfase O/A, gotículas <100 nm. Portanto, a microemulsão contendo o derivado de dilapiol mostrou ser uma alternativa para veiculação tópica de fármacos.

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Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

Cited by 15 publications

References 186 publications

Extracted Eucalyptus globulus Bark Fiber as a Potential Substrate for Pinus radiata and Quillaja saponaria Germination

Extracted Eucalyptus globulus Bark Fiber as a Potential Substrate for Pinus radiata and Quillaja saponaria Germination

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Caracterização de uma microemulsão contendo um derivado do dilapiol extraído de Piper aduncum (Piperaceae)

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