Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

Seiva, Fábio Rodrigues Ferreira; Chuffa, Luiz Gustavo de Almeida; Braga, Camila Pereira; Amorim, João Paulo de Arruda; Fernandes, Ana Angélica Henrique

doi:10.1016/j.fct.2012.07.009

Cited by 75 publications

(58 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quercetin (75 mg/kg, administered in 30 day-old male Wistar rats over 42 days) has been shown to normalize HDLcholesterol, reduce insulin, leptin, glucose and creatinine levels and increased glutathione peroxidase and superoxide dismutase activities after MSG subcutaneous application (4 mg/g administered in neonatal rats from 2. to 12.day) (Seiva et al 2012). …”

Section: Prevention Of Msg Toxic Effectsmentioning

confidence: 99%

Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review

Husarova¹,

Ostatníková²

2013

JMED

View full text Add to dashboard Cite

Monosodium Glutamate (MSG) is one of the world's most widely used food additives. Its toxic effects have been shown in numerous animal studies, however in most of them, the method of administration and the doses were not similar to human MSG intake. In this paper we review animal and human studies in which MSG effects on central nervous system, adipose tissue and liver, reproductive organs and other systems have been shown and we discuss their implications for human MSG intake.

show abstract

Section: Prevention Of Msg Toxic Effectsmentioning

confidence: 99%

Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review

Husarova¹,

Ostatníková²

2013

JMED

View full text Add to dashboard Cite

show abstract

“…Moreover, quercetin normalized glucose levels and minimized the extracts related toxic effects on liver and kidney functions. These effects are associated with the powerful antioxidant properties of quercetin 62 . Anthocyanins of soybean have antioxidant effect and can be useful for the treatment of diabetes, cardiovascular disorders and cancers 63 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

The present study was initiated to quantify the Isoflavones content that accumulated in soybean transgenics with RnPPARγ gene by using high performance liquid chromatography. The effects of methanolic leaves extract of transformed soybean in 3T3-L 1 adipocyte cell line. The RnPPARγ transgenic soybean variety JS335 was developed and transgenics were confirmed by PCR and Southern blot techniques. The quantification of isoflavones compounds by HPLC showed that methanolic leaves extracts of transformed soybean contained Genistein (1.67µg/g extract), Daidzein (2.76µg/g extract), Rutin (32.06µg/g extract) and Quercetin (48.40µg/g extract) and methanolic leaves extracts of nontransformed soybean contained Genistein (1.23µg/g extract), Daidzein (2.33µg/g extract), Rutin (26.16µg/g extract) and Quercetin (43.03µg/g extract) by comparing the chromatogram of the reference standards. In the present study revealed that secondary metabolite content was higher in the transformed plant than non-transformed plants. After treatment of transformed methanolic leaves, extracts on 3T3-L 1 mature adipocytes significantly ameliorated lipid droplet accumulation and droplet reduction in adipocytes might be the result of lipid metabolism by lipolysis.

show abstract

“…The ovariumMDA is a decomposition product of peroxidized polyunsaturated fatty acids that as marker for detection of ROS reactivity toward lipid peroxidation 20,21 .This altered lipid profile accompanied with elevation in reactive oxygen species formation and reduction of antioxidant activities, including SOD and GSH-Px 9,22 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin C-E ve Monosodyum Glutamata Bağlı Ovaryan Toksisite

Rohmawati¹,

Istiananingsih²,

Nurdiana³

et al. 2014

Cukurova Medical Journal

View full text Add to dashboard Cite

Purpose: Our study aimed to investigate the combinatorial effect of vitamin C and E on oxidative stress, the number of folicles, and hormonal level in female rats orally exposed to monosodium glutamate (MSG). Materials and Methods:Female, twelve weeks old Wistar rats ingested with of MSG at dose 140 mg/200 gram body weight (bw) with or without combination of vitamin C and E. Twenty five rats were divided into five group (n = 5 each), control group, MSG-treatment group, MSG-treatment + 0.2 mg/g bw vitamin C + 0.04 IU/g bw vitamin E (MSG + CE1), MSG-treatment + 0.4 mg/g bw vitamin C + 0.04 IU/g bw vitamin E (MSG + CE2), and MSG-treatment + 0.6 mg/g bw vitamin C + 0.04 IU/g bw vitamin E (MSG + CE1). Analysis of malondialdehyde (MDA) level was done colorimetrically. Analysis of the number of ovarian follicles was done histopathologically with hematoxylin eosin staining. Analysis of 17β-estradiol and follicle stimulating hormone (FSH) levels were done by ELISA technique. Results: There were significantly (P < 0.05) increased ovarium MDA levels and atresia follicle number in groups exposed to MSG compared to non-exposure group. The level of FSH, 17β-estradiol, the number of primary, secondary, de Graaf follicles were significantly lower in MSG-treatment group compared to control group (P < 0.05). The administration of combined vitamin C and E (second and third dose) significantly (P < 0.05) decreased the MDA levels and the number of atresia follicle compared to the MSG-exposed groups, to reach level in control group (P > 0.05). MSG + CE2 and MSG + CE3 significantly increased FSH level, number of primary follicles, compared to MSG-treatment group (P < 0.05), to reach similar level in control group (P > 0.05). All dose of combined vitamin C and E significantly increased 17β-estradiol level and the number of secondary and de Graaf follicles compared to MSG-treatment group (P < 0.05), to reach significantly higher level compared to control group (P < 0.05). Conclusion:The present data suggest that combination of vitamin C and E as in this study inhibited ovarium toxicity caused by MSG treatment. Keywords: glutamate; antioxidant; folliculogenesis; hormone; lipid peroxidation Sadece MSG verilmiş grup ile karşılaştırıldıklarında; C ve E vitaminlerinin tüm dozlarının, 17β-estradiol düzeyi ile sekonder ve graff folikül sayılarını anlamlı olarak arttırdıkları tespit edilmiştir (P < 0.05). C ve E vitaminlerinin verildiği gruplarda, 17β-estradiol düzeyi ile sekonder ve graffolikül sayıları, kontrol grubunun üzerindeki düzeylere ulaşmıştır (P < 0.05).Sonuç: Bulgularımız C ve E vitamin kombinesinin MSG'ya maruz kalmaya bağlı olarak gelişen ovaryum toksisitesini inhibe ettiği sonucunu ortaya koymuştur.

show abstract

Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

Cited by 75 publications

References 41 publications

Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review

Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review

Untitled

Vitamin C-E ve Monosodyum Glutamata Bağlı Ovaryan Toksisite

Contact Info

Product

Resources

About