Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells

Truong, Xuan T.; Park, Seo-Hee; Lee, Yu-Geon; Jeong, Hang Yeon; Moon, Jae‐Hak; Jeon, Tae‐Il

doi:10.3390/ijms18081809

Cited by 36 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding inhibition of tyrosinase activity, G. pfeifferi was the most effective fungal species (15.89 mg KAE/g extracts), followed by G. resinaceum (14.76 mg KAE/g), G. applanatum (14.58 mg KAE/g), and G. lucidum (12.74 mg KAE/g). The presence of protocatechuic and chlorogenic acids in G. pfeifferi extract could justify the anti‐tyrosinase activity performed in the present study [45,46] . Contrary to our results, previously published data did not show any inhibitory effects of G. applanatum and G. recinaceum H 2 O extracts on tyrosinase activity [7] .…”

Section: Resultscontrasting

confidence: 99%

Anti‐Inflammatory, Antioxidant and Enzyme Inhibition Activities in Correlation with Mycochemical Profile of Selected Indigenous Ganoderma spp. from Balkan Region (Serbia)

Rašeta

Popović

Beara

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

The aim of this research work was to study the bioactivity potentials (antioxidant, anti‐inflammatory, and enzyme inhibitory) of ethanol (EtOH), water (H2O) and chloroform (CHCl3) extracts of G. applanatum, G. lucidum, G. pfeifferi and G. resinaceum as well as their mycochemical profile: the total content of phenolics (TP) and sugars (TS) and LC/MS/MS detection of phenolics. LC/MS/MS profile showed that p‐hydroxybenzoic and protocatechuic acids were mostly found. The highest ABTS and DPPH activities were detected in polar G. applanatum extracts (159.84±0.59 mg TE/g d.w., IC50=0.85±0.30 μg/mL, respectively), while G. resinaceum CHCl3 extract was the most potent in NO assay (IC50=41.21±0.18−81.89±0.81 μg/mL). The highest TP and TS were generally determined in G. applanatum EtOH extracts. Enzyme inhibitory effects were determined in H2O extracts. Generally, CHCl3 extracts showed the most powerful anti‐inflammatory potential. These results suggest that analyzed species are a promising source of bioactive compounds and may be considered as candidates for new food supplements or drug formulations.

show abstract

Section: Resultscontrasting

confidence: 99%

Anti‐Inflammatory, Antioxidant and Enzyme Inhibition Activities in Correlation with Mycochemical Profile of Selected Indigenous Ganoderma spp. from Balkan Region (Serbia)

Rašeta

Popović

Beara

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…The reports stated that trough the suppression of melanogenic enzymes and microphthalmia-associated transcription factor (Mitf) in α-melanocyte stimulating hormone-stimulated mouse melanoma cells PCA can decrease melanin content and cellular tyrosinase activity. 37 A study in Spain also investigated the anti-collagenase activity of FA by measuring antioxidant defense parameters based on their photoprotective ability. 38 In a review of FA concerning its cosmeceutical properties it was reported that the compound has the potential to inhibit melanin formation through competitive inhibition of tyrosinase.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids

Girsang

Lister

Ginting

et al. 2020

Mol Cell Biomed Sci

View full text Add to dashboard Cite

Background: Skin-aging is a progressive changes in the skin combine with cumulative extrinsic factors which are mostly caused by free radicals caused by exposure to lots of free radicals molecules from pollutant, wrongly food intake, or too much sun bathing. These free radicals can be tackled by a treatment using antioxidants. Prevention of aging can be done by escalating antioxidant intake. Protocatechuic acid (PCA) and Ferulic acid (FA) have been known for their scavenging properties on free radicals and antiaging activity. Antioxidant and antiaging activity of both compounds have not been compared comprehensively before. Hence, current study was conducted to compare the potential of PCA and FA for their antioxidant and antiaging activities using various methods.Materials and Methods: Antioxidant analysis of PCA and FA was conducted using H2O2 scavenging assay, 2,2’-azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazil (DPPH), and ferric reducing antioxidant power (FRAP). Meanwhile, antiaging activities of PCA and FA were examined using inhibitory activities of tyrosinase, collagenase, elastase, hyaluronidase and tyrosinase.Results: IC50 of scavenging activity of ABTS were 125.18 µg/mL (PCA) and 35.55 µg/mL (FA), inhibition activity of collagenase were 126.16 µg/mL (PCA) and 52.85 µg/mL (FA) and inhibition activity of tyrosinase were 246.42 µg/mL (PCA), 253.58 µg/mL (FA).Conclusion: In conclusion, FA has better ABTS scavenging and collagenase inhibition activities compared to PCA. Meanwhile, PCA has better activity of tyrosinase inhibition than FA.Keywords: antioxidant, antiaging, ferulic acid, protocatechuic acid

show abstract

“…In this study, we found that the ES extract had strong antioxidant effects, inhibited tyrosinase, and regulated whitening-related protein expression. The activities might be attributed to gallic acid and protocatechuic acid detected in ES extract [ 33 , 34 ]. Therefore, ES appears to have the potential to be used for the development of natural cosmetics for skin whitening for effective reduction or prevention of excessive melanin pigmentation in the skin.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and skin-whitening effects of aerial part of Euphorbia supina Raf. Extract

Kang

Jeon

Cha

et al. 2018

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundEuphorbia supina (ES) has been widely used in folk medicine owing to its antibacterial, hemostatic, and anti-inflammatory properties. The aim of this study was to evaluate the antioxidant and skin-whitening effects of a 70% ethanol extract of ES.MethodsThe aerial parts of ES plant were extracted with 70% ethanol. The viability of B16F10 cells was evaluated by MTT assay to determine the non-toxic doses for further experiments. The tyrosinase and cellular tyrosinase activities were then measured using an enzyme-substrate assay. In addition, the expression of whitening-related proteins was measured using western blot.ResultsThe antioxidant activity of the ES samples increased in a dose-dependent manner, as confirmed by their radical scavenging activities in the 2,2-diphenyl-1-1-picrylhydrazyl and 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) assays. The ES extract significantly reduced tyrosinase activity and melanin content in a dose-dependent manner. Furthermore, it decreased α-melanocyte stimulating hormone (MSH)-induced protein expression of tyrosinase and microphthalmia-associated transcription factor (MITF).ConclusionsOur results indicate that the ES extract attenuated α-MSH-stimulated melanin synthesis by modulating tyrosinase and MITF expression. Therefore, the ES extract could be a promising therapeutic agent to treat hyperpigmentation and as an ingredient for skin-whitening cosmetics.

show abstract

Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells

Cited by 36 publications

References 21 publications

Anti‐Inflammatory, Antioxidant and Enzyme Inhibition Activities in Correlation with Mycochemical Profile of Selected Indigenous Ganoderma spp. from Balkan Region (Serbia)

Anti‐Inflammatory, Antioxidant and Enzyme Inhibition Activities in Correlation with Mycochemical Profile of Selected Indigenous Ganoderma spp. from Balkan Region (Serbia)

Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids

Antioxidant and skin-whitening effects of aerial part of Euphorbia supina Raf. Extract

Contact Info

Product

Resources

About