Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids

Abstract

<jats:p>Background: Skin-aging is a progressive changes in the skin combine with cumulative extrinsic factors which are mostly caused by free radicals caused by exposure to lots of free radicals molecules from pollutant, wrongly food intake, or too much sun bathing. These free radicals can be tackled by a treatment using antioxidants. Prevention of aging can be done by escalating antioxidant intake. Protocatechuic acid (PCA) and Ferulic acid (FA) have been known for their scavenging properties on free radicals and antiaging activity. Antioxidant and antiaging activity of both compounds have not been compared comprehensively before. Hence, current study was conducted to compare the potential of PCA and FA for their antioxidant and antiaging activities using various methods.Materials and Methods: Antioxidant analysis of PCA and FA was conducted using H2O2 scavenging assay, 2,2’-azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazil (DPPH), and ferric reducing antioxidant power (FRAP). Meanwhile, antiaging activities of PCA and FA were examined using inhibitory activities of tyrosinase, collagenase, elastase, hyaluronidase and tyrosinase.Results: IC50 of scavenging activity of ABTS were 125.18 µg/mL (PCA) and 35.55 µg/mL (FA), inhibition activity of collagenase were 126.16 µg/mL (PCA) and 52.85 µg/mL (FA) and inhibition activity of tyrosinase were 246.42 µg/mL (PCA), 253.58 µg/mL (FA).Conclusion: In conclusion, FA has better ABTS scavenging and collagenase inhibition activities compared to PCA. Meanwhile, PCA has better activity of tyrosinase inhibition than FA.Keywords: antioxidant, antiaging, ferulic acid, protocatechuic acid</jats:p>

Development of a Novel Electrochemical Biosensor Based on Carbon Nanofibers–Gold Nanoparticles–Tyrosinase for the Detection of Ferulic Acid in Cosmetics

“…[ 1 , 2 ]. FA is known as an antiaging [ 3 ], anti-inflammatory [ 4 ], antithrombotic [ 5 ], antidiabetic [ 6 ], antiulcerigen [ 7 ], antihemolitic [ 8 ], antiviral [ 9 ] and even anti-carcinogenic agent [ 10 ]. Due to the antibacterial effect, it may also be used in certain implants [ 11 ].…”

The Potential of Tamarillo (Solanum betaceum) Peel as an Antioxidant by Radical Scavenging DPPH and Antiaging by Collagenase Inhibition

“…Other studies have shown that gallic acid coated with gold nanoparticles has a superior ability to inhibit the degradation of type I collagen mediated by high glucose in dermal fibroblast cells (Wu et al, 2021). Another study illustrated that the collagenase inhibition activity of ferulic acid is 52.85 µg/mL, which falls into the strong category (Girsang et al, 2020). With collagenase inhibition activity and DPPH scavenging, SBPE shows promising potential as a good antioxidant and anti-aging agent.…”

Indonesian Purple Rice Ferulic Acid as a Candidate for Anti-aging through the Inhibition of Collagenase and Tyrosinase Activities

“…Kojic acid was used as the positive control. The collagenase and tyrosinase inhibitory activity was calculated using the following equation [31]:…”

“…Compounds with antioxidant activity could prevent aging by inhibiting the activities of ROS and aging enzymes [31]. The ROS activates the MAPK pathway, which increases microphthalmia-associated transcription factor (MITF) expression and thus tyrosinase-regulated melanogenesis [5].…”