Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat

Abstract

Cisplatin is one of the most active cytotoxic agents in the treatment of cancer. High doses of cisplatin have also been known to produce hepatotoxicity. Several studies suggest that supplementation with an antioxidant can influence cisplatin-induced hepatotoxicity. The present study was designed to determine the effects of cisplatin on the liver oxidant/antioxidant system, and the possible protective effects of caffeic acid phenethyl ester (CAPE) on liver toxicity induced by cisplatin. Twenty-four adult female Wistar albino rats were divided into four groups of six rats each: control, cisplatin, CAPE, and cisplatin+CAPE. Cisplatin and CAPE were injected intraperitoneally. Liver tissue was removed to study the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), myeloperoxidase (MPO), xanthine oxidase (XO), adenosine deaminase (ADA), and the levels of malondialdehyde and nitric oxide (NO). The activities of SOD and GSH-Px increased in the cisplatin+CAPE and CAPE groups compared with the cisplatin group. CAT activity was higher in the cisplatin +CAPE group than the other three groups. XO activity was lower in the cisplatin group than the control group. MPO activity was also increased in the cisplatin group compared to the control and CAPE groups. It can be concluded that CAPE may prevent cisplatin-induced oxidative changes in liver by strengthening the antioxidant defence system by reducing reactive oxygen species and increasing antioxidant enzyme activities.

Antioxidant Effects of <i>Nigella Sativa</i> in the Treatment of Experimentally Induced Rhinosinusitis

“…The present study has demonstrated one important result to explain the sources of the ROS: high MPO activity in the experimental induced rhinosinusitis. It seems that the source of ROS is mostly due to neutrophil activity rather than from the experimental induced rhinosinusitis mucosa itself [29].…”

The Yeast Genes ROX1, IXR1, SKY1 and Their Effect upon Enzymatic Activities Related to Oxidative Stress

“…It has been proposed that oxidative stress exists in the early stage of cisplatin-induced nephrotoxicity and also in hepatotoxicity (Iraz et al, 2006;Mansour et al, 2006;Pratibha et al, 2006;Satoh et al, 2000). In rats, mitochondrial dysfunction in kidney and liver was evidenced after cisplatin treatment.…”

Tissue Damage and Oxidant/Antioxidant Balance

“…The occurrence of tissue damage is determined by the oxidant/antioxidant balance [3]. The oxidant/antioxidant balance changes in favor of oxidants in various damage models created in living tissues, and decreases in antioxidant levels are observed, whereas the oxidant levels increase [4]. Uzar et al [5] reported decreases in the total antioxidant level and increases in the oxidant level in the context of brain ischemia-reperfusion damage.…”