The oxidant/antioxidant balance in healthy tissues is maintained with a predominance of antioxidants. Various factors that can lead to tissue damage disrupt the oxidant/antioxidant balance in favor of oxidants. In this study, disruptions of the oxidant/antioxidant balance in favor of oxidants were found to be a consequence of the over-consumption of antioxidants. For this reason, antioxidants are considered to be of importance in the prevention and treatment of various types of tissue damage that are aggravated by stress.
Key Words: Antioxidant, Ischemia, Oxidant
ÖzetSağlıklı dokularda oksidan/antioksidan denge antioksidanların üs-tünlüğüyle sürdürülür. Doku hasarına yol açabilecek çeşitli agresif faktörler oksidan/antioksidan dengenin oksidanların leyhine bozulmasını sağlar. Bu derleme çalışmasında, oksidan/antioksidan dengenin oksidanlar leyhine bozulmasının, antioksidan sistemlerin aşırı harcanmasına bağlı olarak geliştiği rapor edilmiştir. Bu nedenle oksidatif strese bağlı çeşitli doku hasarının önlenmesinde ve tedavisinde antioksidanların önemli olduğu anlaşılmaktadır.
INGEC, M., BOREKCI, B. and KADANALI, S. Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia. Tohoku J. Exp. Med., 2005, 206 (3), 225-231 Homocysteine is an essential amino acid required for the growth of cells and tissues in the human body. Maternal hyperhomocysteinemia is associated with a number of placenta-mediated diseases such as preeclampsia. The aim of this study was to evaluate the plasma level of homocysteine and its association with severity of preeclampsia. A case-control study was performed with 32 mild preeclamptic patients, 25 severe preeclamptic patients, 16 eclamptic patients and 34 controls. Maternal plasma homocysteine concentration was measured prospectively at antenatal period by high-performance liquid chromatography. There were no significant differences in demographic characteristics between the study and control groups. Mean plasma levels of homocysteine in women with severe preeclampsia (16.7 ± 10.1 μ mol/l, mean ± S.D., n = 25) and eclampsia (16.5 ± 9.6 μ mol/l, mean ± S.D., n = 16) were significantly higher than those in mild preeclampsia (7.7 ± 2.4 μ mol/l, mean ± S.D., n = 32) and controls (6.7 ± 1.6 μ mol/l, mean ± S.D., n = 34) (p < 0.0001). It should be noted that plasma levels of homocysteine are not significantly different between mild preeclampsia and controls. In conclusion, plasma homocysteine concentrations are increased in severe preeclampsia and eclampsia, but not in mild preeclampsia.
Ischemia-reperfusion damage is a complex pathological process that begins with tissue anoxia and continues with the production of free oxygen radicals, expanding with the inflammatory response. The literature suggests the importance of antioxidant and anti-inflammatory treatment to treat ischemia-reperfusion-related tissue damage.
Magnesium assimilation is known to be defective when iodine levels are insufficient. In northeast Anatolia, where iodine deficiency is common, clinical trials of iodine supplementation should be considered for pre-eclamptic therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.