Ischemia-Reperfusion Damage

Abstract

Ischemia-reperfusion damage is a complex pathological process that begins with tissue anoxia and continues with the production of free oxygen radicals, expanding with the inflammatory response. The literature suggests the importance of antioxidant and anti-inflammatory treatment to treat ischemia-reperfusion-related tissue damage.

Effect of Kineret® on ovarian ischemia reperfusion injury in a rat model

“…IR injury begins when tissues become deprived of oxygen, continues with the production of free oxygen radicals and expands with an inflammatory response. 3 Our biochemical results indicated that MDA and MPO levels were increased and the tGSH level was decreased in the ovarian tissue of the IRG group, which was subjected to the IR process alone. Yapca et al reported that reperfusion application on the ischemic ovarian tissue leads to an increase in MDA and MPO production and a decrease in both tGSH and enzymatic antioxidants, causing oxidative stress.…”

“…22 MDA, as an oxidant parameter, is a toxic product occurring during oxidation of the cellular membrane lipids by free oxygen radicals, known as reperfusion mediators. 3,23 Demiryilmaz et al reported a significantly increased MDA level in rat ovarian tissue subjected to IR. 24 In the present study, a significant increase was also noted in MPO activity in the ovarian tissue of the IRG group, in addition to an increase in MDA levels.…”

“…When intervention to ischemic tissue caused by ovarian torsion is not taken, a series of chemical events occur, extending to cellular dysfunction and necrosis. 3 Therefore, the first intervention for ischemic ovarian tissue is to provide detorsion of the ovaries and reperfusion of the affected tissue. 4 However, supplying oxygen to the ischemic tissue with abundant blood starts a reaction process that further injures the tissue.…”

“…6 Free oxygen radicals, known as reperfusion mediators, oxidize cellular membrane lipids, causing the formation of toxic products, such as aldehyde and malondialdehyde (MDA), from the lipids. 3 Although a number of studies have been conducted to determine the mechanism of IR injury, the pathophysiology of this event is not yet fully understood. Increased oxidative stress, as a result of the activation of free oxygen radicals and polymorphonuclear leukocytes (PNL), is considered the major component.…”

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

“…However, it was also reported that even lower doses of MTX (2.5 mg/kg) leads to marked oxidative damage in rat small intestines [3]. Oxidative stress is a change in oxidant/antioxidant balance in any tissue in favour of oxidants [31]. The increased levels of MDA and MPO, and decreased levels of tGSH, GSHRd, GSHPx, CAT and SOD in the rats given MTX in the present study confirm the results of Kolli et al [13].…”