Antioxidant Effects of <i>Nigella Sativa</i> in the Treatment of Experimentally Induced Rhinosinusitis

Abstract

Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental bacterial rhinosinusitis. Material and Methods.Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into control, NS 50, NS 100 and NS 200 mg/kg/d groups. NS was given orally for 7 days. The same volume of normal saline was given as a vehicle to the control group for the same period. At 7 days post-treatment, mucosal samples were excised from the treated and control groups for measurements of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), myeloperoxidase (MPO) and malondialdehyde (MDA). Conclusion. These findings show that administration of NS increased the SOD, GSH-Px activities and decreased the lipid peroxidation and MPO activity in experimental rhinosinusitis in rabbits. NS prevented oxidative stress by scavenging reactive oxygen species generated in rhinosinusitis model in rabbits. Results. SOD and GSH-Px activities significantly increased in the NS

<b><i>Nigella Sativa</i></b> Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

“…In addition, they have anti-inflammatory effects and have been consumed as condiment [29,30,31]. NS contains fixed and volatile oils.…”

Antioxidant potential of some Sudanese medicinal plants used in traditional medicine

“…Essential oil of black cumin provided antioxidant activity equivalent to or higher than those of synthetic antioxidants and could be a better natural antioxidant [49].N. sativa extract and Curcumin revealed reducing power and antioxidative potentials attributed to high total phenolic contents and possessed valuable as food preservative and nutritional health supplements [50] .N. sativa increased the superoxide dismutase, glutathione peroxidase activities and decreased the lipid peroxidation, myeloperoxidase activity, preserve the cell membrane integrity and prevented oxidative stress by scavenging reactive oxygen species [51][52][53][54][55].Black cumin seed oil, and its fractions exhibited moderate antioxidant; the phospholipid exhibited greater antioxidant followed by glycolipids and neutral lipids [56].…”

Down-regulation of GST and CAT gene expression by methanolic extract of Nigella sativa seed in human peripheral blood mononuclear cells

“…Moreover, NS oil has been an antioxidant activity (Machmudah et al, 2005). One of the potential properties of NS is the ability of its constituents to reduce toxicity due to its antioxidant activities (Yoruk et al, 2010). The consequences of consuming high levels of antioxidants, even naturally occurring ones, over the long period of *Corresponding authors.…”

“…Oxidative stress is recognized as one of the major contributors for the increased risk of chronic diseases such as cancer and cardiovascular diseases (Moylan and Reid, 2007). NS has clear antioxidant properties and can be used as an antioxidant against oxidative stress (Sen et al, 2010;Yoruk et al, 2010). NS seeds are good source of natural antioxidants such as selenium, thymoquinone, vitamins E and A.…”