Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery

Linares, Vicente; Casas, Marta; Caraballo, Isidoro

doi:10.1016/j.ejpb.2018.11.021

Cited by 64 publications

(29 citation statements)

References 39 publications

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“…Three-dimensional printing (3DP) is an innovative additive manufacturing technology that has come to the fore in the preparation of personalised dose printlets (3D printed tablets) [10][11][12][13][14]. 3D printing is an umbrella term that encompasses various technologies, many of which have already been evaluated in the pharmaceutical field [15][16][17][18], including powder bed inkjet printing, fused deposition modelling (FDM) [19][20][21][22][23][24][25][26][27], semi-solid extrusion (SSE) [28][29][30][31][32][33], selective laser sintering (SLS), direct powder extrusion (DPE) [34] and stereolithography (SLA) [15,[35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

142

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The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

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Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

142

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“…Ordinarily, the automated filling process is realized upon modifying a dualextruder 3D printer, by replacing a printhead with a syringe [20,21]. Recently, a modular 3D printer, previously used only for tissue applications, provided the ability of both FFF printing and injection volume filling [22]; this device facilitated the development of capsules with unique drug release profiles of solutions and suspensions.…”

Section: Filled Formulationsmentioning

confidence: 99%

Manufacturing of hybrid drug delivery systems by utilizing the fused filament fabrication (FFF) technology

Eleftheriadis

Katsiotis

Genina

et al. 2020

Expert Opinion on Drug Delivery

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The potential of fused filament fabrication (FFF) for the administration of active pharmaceutical compounds is a recent approach to develop complex and custom-made drug delivery systems (DDSs). However, the FFF technology is characterized by certain limitations, which are associated with the nature of the process, i.e., the required mechanical properties of the feedstock, as well as the thermal stability of the incorporated polymers, excipients and active compounds. Thus, hybrid DDSs have been recently introduced, to overcome these boundaries. The concept of these systems is defined by the effective coupling of FFF with conventional manufacturing technologies, as a novel pathway to expand the available pool of raw materials and pharmaceutical applications of FFF.

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“…Bioprinters are thought with the purpose of being suitable for working with cells and biocompatible materials. These “3D bioprinting technologies” can also be used for pharmaceutical systems [ 19 ], in addition to other areas like nourishment [ 20 ], which have similar requirements [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

Self Cite

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In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.

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Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery

Cited by 64 publications

References 39 publications

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Manufacturing of hybrid drug delivery systems by utilizing the fused filament fabrication (FFF) technology

3D Printed Drug Delivery Systems Based on Natural Products

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