Manufacturing of hybrid drug delivery systems by utilizing the fused filament fabrication (FFF) technology

Eleftheriadis, Georgios K.; Katsiotis, Christos S.; Genina, Natalja; Boetker, Johan; Fatouros, Dimitrios G.

doi:10.1080/17425247.2020.1776260

Cited by 20 publications

(6 citation statements)

References 38 publications

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“…It has also been demonstrated that amorphization via hot-melt extrusion and subsequent FDM can produce formulations in which the drug quickly recrystallizes [44]. These limitations of FDM are starting to be addressed via the use of a combinatorial approach involving novel hybrid systems, comprising one part produced via FDM and another part produced by a different technique to overcome the shortcomings of their respective techniques [45].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs

et al. 2021

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Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms. In the present study, mesoporous materials were incorporated into a thermoplastic filament produced via hot-melt extrusion and used to produce oral dosage forms via FDM. Mesoporous materials are known to be highly effective for the amorphization and stabilization of poorly soluble drugs, and were therefore studied in order to determine their ability to enhance the drug-release properties in 3D-printed tablets. Celecoxib was selected as the model poorly soluble drug, and was loaded into mesoporous silica (MCM-41) or mesoporous magnesium carbonate. In vitro drug release tests showed that the printed tablets produced up to 3.6 and 1.5 times higher drug concentrations, and up to 4.4 and 1.9 times higher release percentages, compared to the crystalline drug or the corresponding plain drug-loaded mesoporous materials, respectively. This novel approach utilizing drug-loaded mesoporous materials in a printed tablet via FDM shows great promise in achieving personalized oral dosage forms for poorly soluble drugs.

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Section: Introductionmentioning

confidence: 99%

3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs

et al. 2021

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“…Moreover, FDM provides a competent alternative to the conventional manufacturing techniques for substrates (e.g., solvent casting and injection molding), by avoiding time-demanding steps (e.g., drying) and the need for incorporating additional equipment (e.g., molds). The current approach is built on the general hybridization concept for additive manufacturing of drug delivery systems [21,22]. It has been claimed that the administration of drugs via the oral cavity may provide a dependable and useful alternative to the peroral route, as the formulation avoids the environmental challenges imposed by the segments of the gastrointestinal tract and circumvents the first-pass effect [23].…”

Section: Introductionmentioning

confidence: 99%

Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation

Eleftheriadis

Katsiotis

Andreadis

et al. 2020

Drug Development and Industrial Pharmacy

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Objective: The inkjet printing (IP) and fused deposition modeling (FDM) technologies have emerged in the pharmaceutical field as novel and personalized formulation approaches. Specific manufacturing factors must be considered in each adopted methodology, i.e., the development of suitable substrates for IP and the incorporation of highly thermostable active pharmaceutical compounds (APIs) for FDM. In this study, IP and FDM printing technologies were investigated for the fabrication of hydroxypropyl methylcellulose-based mucoadhesive films for the buccal delivery of a thermolabile model drug. Significance: This proof-of-concept approach was expected to provide an alternative formulation methodology for personalized mucoadhesive buccal films. Methods: Mucoadhesive substrates were prepared by FDM and were subjected to sequential IP of an ibuprofen-loaded liquid ink. The interactions between these processes and the performance of the films were evaluated by various analytical and spectroscopic techniques, as well as by in vitro and ex vivo studies. Results: The model drug was efficiently deposited by sequential IP passes onto the FDM-printed substrates. Significant variations were revealed on the morphological, physicochemical and mechanical properties of the prepared films, and linked to the number of IP passes.The mechanism of drug release, the mucoadhesion and the permeation of the drug through the buccal epithelium were evaluated, in view of the extent of ink deposition onto the buccal films, as well as the distribution of the API. Conclusions: The presented methodology provided a proof-of-concept formulation approach for the development of personalized mucoadhesive films.

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“…Furthermore, the 2D inkjet printing technology provides the potential to advance the loading of poorly soluble drugs in a medicinal formulation, following the exploitation of suitable solvents in the development of inks [6]. The inkjet printing technique has been coupled with other formulation approaches, to fabricate hybrid drug delivery systems [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

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Manufacturing of hybrid drug delivery systems by utilizing the fused filament fabrication (FFF) technology

Cited by 20 publications

References 38 publications

3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs

3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs

Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

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