Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Abstract

Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose

“…A key advantage of PAM over most 3DP technologies is that it can process a wide variety of polymers, whereas FDM is limited to thermoplastics. The film thicknesses were comparable with those reported by inkjet printing (IJP), a 3DP technology widely used for OFs, although lower thicknesses can be achieved by IJP (Dodoo et al, 2020;Eleftheriadis et al, 2020;Öblom et al, 2020). However, IJP is limited with regards to drug loading, whereas PAM can achieve loading as high as 80 % w/w (Keikhosravi et al, 2020;Khaled et al, 2018).…”

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

“…Thiamine hydrochloride (THCl) and nicotinic acid (NA)-loaded propyleneglycol (PG) buccal films have been developed using a two-dimensional (2D) inkjet printing method [43]. The rough surface and formation of a pore network in the films were revealed by SEM images.…”

Methods to Produce Nicotinic Acid with Potential Industrial Applications

“…NA is also sold in the form of dietary supplements and mixtures for the prevention of venous insufficiency [4], leukemia [5], heart disease and anemia [6], atherosclerosis [7], insulin resistance [8], diabetic nephropathy [9], peptic ulcer disease [10], Alzheimer's disease [11], Parkinson's disease [12], or neoplastic diseases [13,14]. Modern preparations can be found such as cheek foils containing NA as the active substance [15]. NA has a potential anti-inflammatory and analgesic effect [16], and in dermatology, NA is used to treat acne vulgaris and rosacea [17] and is a popular ingredient in cosmetics to care for the skin and hair [18,19].…”