Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham, Nour; Fina, Fabrizio; Marcuta, Carmen; Kraschew, Lilia; Mohr, W.; Gaisford, Simon; Basit, Abdul W.; Goyanes, Álvaro

doi:10.3390/pharmaceutics12020110

Cited by 142 publications

(99 citation statements)

References 52 publications

(57 reference statements)

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“…To date, although only a few papers related to the production of SODFs by SLS have been issued [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ], they demonstrated clearly that it is possible to manufacture oral medicines with a sintering machine using different pharmaceutical thermoplastic polymers (copovidone, cellulose derivatives and Eudragit ® ). These contributions distinctly highlight the most important benefit that SLS could have in pharmaceutical manufacturing: its ability to create more or less porous forms by modulating the printing parameters and hence control the drug release from the printed SODFs.…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that although all the aforementioned work was conducted with SLS machines that use a blue diode laser, none of the evaluated polymers absorbed at the wavelength of the laser. Therefore, a colorant e.g., “Candurin ® ” was added to enhance the absorbance and allow the sintering process [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Nonetheless, the majority of commercially available SLS printers use a different laser beam, which is the carbon dioxide (CO 2 ) laser beam (λ = 10.6 μm).…”

Section: Introductionmentioning

confidence: 99%

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Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser

et al. 2021

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Material suitability needs to be considered for the 3D printing of solid oral dosage forms (SODFs). This work aims to assess the suitability of a CO2 laser (λ = 10.6 μm) for selective laser sintering of SODFs containing copovidone and paracetamol. First, physicochemical characterization of powders (two grades of copovidone, two grades of paracetamol and their mixtures at various proportions) was conducted: particle size distribution, morphology, infrared absorbance, flowability, and compactness. Then, printing was launched, and printability of the powders was linked to their physicochemical characteristics. The properties of the sintered SODFs were evaluated (solid state, general aspect, porosity, hardness, drug content and release). Hence, it was found that as copovidone absorbs at the laser’s wavelength, sintering was feasible without using an absorbance enhancer. Also, flowability, which mainly depends on the particle size, represents the first control line for “sinterability” as a fair flow is at least required. Low compactness of copovidone and mixtures reduces the mechanical properties of the SODFs but also increases porosity, which can modulate drug release. Moreover, the drug did not undergo degradation and demonstrated a plasticizer effect by lowering the heating temperature. In conclusion, this work proves the applicability of CO2 laser SLS printer to produce SODFs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser

et al. 2021

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“…Selective laser sintering (SLS) is a powder-based 3D printing technology in which a laser beam is used to selectively bind powder particles together to create 3D objects [48][49][50]. SLS 3D printing is used in the fields of tissue engineering to produce scaffolds [51][52][53][54][55], and drug delivery to fabricate printlets with different release characteristics such as orally disintegrating [56][57][58], immediate release and modified release dosage forms [59]. Due to the high resolution of the laser, novel structures, such as 3D-gyroid lattices, bi-layer printlets [60] and dual miniprintlets [61], can be easily fabricated using different polymers, which could be engineered to exhibit customised drug release profiles tailored to individual patient needs.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

et al. 2020

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Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment.

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“…Extensive research has been conducted on the application of using SLS in the printing of medicine [ 11 ], selected works include printing of immediate-release [ 5 ], sustained/controlled/modified release [ 12 , 13 ], multi-drug containing [ 14 ], and orally disintegrating dosage forms [ 15 ]. Although SLS has proven to be a versatile solvent-free technique for printing dosage forms, most of the drug candidates used in the conducted research belong to the class I of the biopharmaceutical classification system (BCS).…”

Section: Introductionmentioning

confidence: 99%

Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool

et al. 2020

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This research demonstrates the use of fill density as an effective tool for controlling the drug release without changing the formulation composition. The merger of hot-melt extrusion (HME) with fused deposition modeling (FDM)-based 3-dimensional (3-D) printing processes over the last decade has directed pharmaceutical research towards the possibility of printing personalized medication. One key aspect of printing patient-specific dosage forms is controlling the release dynamics based on the patient’s needs. The purpose of this research was to understand the impact of fill density and interrelate it with the release of a poorly water-soluble, weakly acidic, active pharmaceutical ingredient (API) from a hydroxypropyl methylcellulose acetate succinate (HPMC-AS) matrix, both mathematically and experimentally. Amorphous solid dispersions (ASDs) of ibuprofen with three grades of AquaSolveTM HPMC-AS (HG, MG, and LG) were developed using an HME process and evaluated using solid-state characterization techniques. Differential scanning calorimetry (DSC), powder X-ray diffraction (pXRD), and polarized light microscopy (PLM) confirmed the amorphous state of the drug in both polymeric filaments and 3D printed tablets. The suitability of the manufactured filaments for FDM processes was investigated using texture analysis (TA) which showed robust mechanical properties of the developed filament compositions. Using FDM, tablets with different fill densities (20–80%) and identical dimensions were printed for each polymer. In vitro pH shift dissolution studies revealed that the fill density has a significant impact (F(11, 24) = 15,271.147, p < 0.0001) and a strong negative correlation (r > −0.99; p < 0.0001) with the release performance, where 20% infill demonstrated the fastest and most complete release, whereas 80% infill depicted a more controlled release. The results obtained from this research can be used to develop a robust formulation strategy to control the drug release from 3D printed dosage forms as a function of fill density.

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Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Cited by 142 publications

References 52 publications

Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser

Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool

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