In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.
In the present paper we combine functionalization and biodegradation in the rational design of polymers
that can be used as carrier systems for drug delivery in the colon. Functionalization of new
polyurethanes (PUs) was achieved by thiol–ene coupling reactions, a simple and straightforward
procedure included among the so-called click reactions, which are currently accepted as one of the
most powerful tools in organic chemistry. Enhancement of the degradability of the new materials by the
introduction of disulfide linkages into the polymer backbone has led to a new group of stimulusresponsive
sugar-based polyurethanes able to be degraded by tripeptide glutathione under physiological
conditions. Atomic Force Microscopy (AFM) on solid-supported multilayered dry polymer films—
prepared by spin-coating from dimethylsulfoxide solutions—was used to study the morphology of the
polymers and the degradation process in reductive environments. Matrix systems containing polymers
selected according to their rheological properties were also investigated as modulated methotrexaterelease
system
To formulate a HPMC matrix, the system must be above the polymer's critical point, that is, allowing HPMC to act as outer phase. In this way, a coherent gel layer will be obtained because the first moment and the drug release will be controlled by this layer. Furthermore, knowing the critical points allows the vicinity of these points to be avoided, which are regions of high variability. In this way, robust dosage forms can be obtained.
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