Prevalence of high–risk human papillomavirus in women from turkey

Abstract

Objectives: Data on the seroprevalence of Human papillomavirus (HPV) in Turkey are limited. The aim of this study was to characterize the high risk types of HPV in cervical cytology specimens of women in Turkey during routine cervical cancer screening. Methods:Women aged 30 years and older who had been admitted to Tepecik Education and Research Hospital in İzmir province for routine cervical cancer screening between June 2012 and December 2014 were enrolled to the study. Cervical swab samples were collected for HPV-DNA examination. For identifying HPV genotypes, cervical samples were analyzed by Cobas® 4800 HPV Test qualitative real-time PCR system (Roche Molecular Systems Inc., Alameda, CA, USA) for HPV types 16, 18 and the other 12 high risk HPV (hrHPV) types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68). Results:In this study, the overall HPV positivity was detected in 10.07% (539/5350 samples) of women during routine cervical cancer screening. Of these; HPV type 16 was detected in 187 samples (31.59%), HPV type 18 in 46 samples (7.77%), and other hrHPV (pool of 12 genotypes) in 359 samples (60.64%), either as single or multiple infections combined. Of 539 HPV positive samples, 489 (90.72%) were single type HPV infections and the remainder (n=50, 9.28%) were multiple type infections. There was no significant difference in HPV prevalence by decades of life. Conclusions:Our results showed that hrHPV types other than type 16 or type 18 are the most detected genotypes in women undergoing routine cervical cancer screening. Data of the heterogeneity in HPV type distribution must be taken into account for the decision of vaccination and screening modalities.

Genotype Distribution and Prevalence of High-Risk Human Papillomavirus Infection among Women in Samsun Province of Turkey

“…Some studies have been performed to evaluate the prevalence and genotype of HPV in Turkey, most of which are based on small samples. The prevalence of HR-HPV was reported to be 33.5%, 36.3%, 8.5%, 10.07%, 23.9%, and 2.79% in their studies, respectively (Aydogan et al, 2018, Alacam et al, 2021, Akcali et al, 2013, Bayram et al, 2015, Eroglu and Asgin 2020, Kulhan et al, 2017. In a study conducted on 2234 Turkish women, HPV positivity was found 38.05%, and the most common type was HPV 16 (Hancer et al, 2018).…”

Concordance of the frequency, typing, and results of high risk human papilloma virus in cervical cytology materials with biopsy: Retrospective analysis of 5604 patients

“…In our study, hrHPV prevalence was found to be 1.2% in cases with normal cytology results and 7.5% in general population and 73.4% in cases with abnormal cytology. In other studies in which hrHPV subtypes were evaluated in our country, this rate ranges between 3.4% and 33.7% (5,(11)(12)(13)(14)(15). The reason for this wide range is that instead of general population, HPV was studied in cases in which the cervical anomaly is detected with smear in the majority of the studies.…”

“…With the exception of three of the studies in our country, including our study, the most common type was found to be HPV 16. This is followed by HPV 18, 31, and 51 (5,6,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Of the three studies with different findings, the most common HPV type was found to be HPV 18 in two studies and HPV 66 in one study (4,22,23).…”

Human Papillomavirus Prevalence and Genotype Distribution in Servical Swab Samples: Outcomes of a Three-Year Analysis

“…Ülkemizdeki HPV prevalansını ve genotip dağılımlarını sunan çalışmalar, farklı coğrafi bölgelerde ve zaman aralıklarındaki verileri içermektedir. Ülkemizde yapılan HPV tarama sonuçlarına ait bazı çalışmalar ise Tablo 2'de sunulmuştur (13,(16)(17)(18)(19)(20) . Ancak, HPV analizinde ve genotiplendirmede kullanılan test metotlarındaki farklılıklar elde edilen verilerin analizini güçleştirmektedir.…”