Genotype Distribution and Prevalence of High-Risk Human Papillomavirus Infection among Women in Samsun Province of Turkey

Taşkın, Mehmet Hakan; Nursal, Ayse; Oruç, Muhammet Ali; Kariptaş, Ergin

doi:10.31557/apjcp.2022.23.7.2477

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…For instance, a study in South Korea, comprising 18,170 women had a HR-HPV positive rate of 12.5% (Ouh et al, 2018). Similarly, a study in Turkey showed that the incidence rate of HR-HPV infection was ∼9.17% (Taskin et al, 2022). Meanwhile, in countries with relatively underdeveloped economies, such as sub-Sahara Africa and Bangladesh, the HR-HPV infection rate was 34% (Seyoum et al, 2022) and ∼41.86% (Sharmin et al, 2021), respectively.…”

Section: Discussionmentioning

confidence: 98%

Status and epidemiological characteristics of high-risk human papillomavirus infection in multiple centers in Shenyang

Yang

Zhang²,

Cui³

et al. 2022

Front. Microbiol.

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Section: Discussionmentioning

confidence: 98%

Status and epidemiological characteristics of high-risk human papillomavirus infection in multiple centers in Shenyang

Yang

Zhang²,

Cui³

et al. 2022

Front. Microbiol.

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“…However, the ranking of the prevalence of these types varies by region [ 7 ]. For instance, in Western Europe, HPV16, 18, 31, 35, and 33, and in North America, HPV16, 53, 18, 51, and 31 are the five most prevalent high-risk HPV strains [ 8 ]. HPV16, 52, and 58 have the highest infection rates in some areas of China [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and genotypes analysis of human papillomavirus infection in Beijing, China

Wang,

Li,

Zhang

et al. 2024

Virol J

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Background This study aimed to investigate the epidemiology of high-risk human papillomavirus (HPV) in the female population in Beijing, China, and identify the relationship between HPV genotypes and host factors. Methods HPV testing was performed on women aged 15–89 (mean age 38.0 ± 10.9 years) from Beijing in 2020. High-risk HPV genotyping real-time polymerase chain reaction was used to determine HPV genotypes. The overall prevalence, age-specific prevalence, genotype distribution, and the correlation between HPV genotypes and cervical cytology were analyzed. Results Among the 25,344 study participants, the single and double infection rates were 18.8% (4,777/25,344) and 4.2% (1,072/25,344), respectively. A total of 6,119 HPV-positive individuals were found to have 91.6% negative results for intraepithelial lesion or malignancy (NILM), 5.8% atypical squamous cells of undetermined significance (ASC-US), 0.9% low-grade squamous intraepithelial lesion (LSIL), and 1.7% high-grade squamous intraepithelial lesion (HSIL). In single HPV infections, the HPV16 genotype was highly associated with cervical cytology severity (χ2 trend = 172.487, P < 0.001). Additionally, HPV infection rates increased gradually with age, and statistical differences were observed across age groups (χ2 = 180.575; P < 0.001). High-risk HPV genotypes were highly prevalent in women below 25 years of age and those aged 55–59 years. Cluster analysis revealed that the 13 HPV genotypes could be roughly divided into two groups in a single infection; however, patterns of infection consistent with biological characteristics were not observed. Conclusion High-risk HPV was found in 24.1% of outpatients, with HPV52, HPV58, HPV16, HPV39, and HPV51 being the most common high-risk genotypes. Single high-risk HPV infection was predominant. HPV16, HPV39, HPV51, and HPV52 were associated with cervical lesion progression. HPV16 infection was especially worrying since it aggravates cervical lesions. Because the infection rates of the 13 HPV genotypes differed by age, the peak HPV infection rate should not guide vaccination, screening, and prevention programs. Instead, these initiatives should be tailored based on the regional HPV distribution characteristics. Moreover, it was determined that Beijing’s populace needed to receive treatment for HPV39 infection.

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“…The leading cause of cervical cancer has been revealed to be human papillomavirus (HPV) infection, which has led to the recognition of CC as a malignancy with a preventable and treatable etiology. Currently, most countries support the prompt deployment of CC screening, using a thorough strategy that includes cervical cytology and HPV testing [ 2 ]. An increasing amount of evidence suggests that HPV vaccinations may significantly reduce the prevalence of HPV infections.…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, HR-HPVs are associated with the development of various cancers, including anogenital cancers (such as anal, vulvar, vaginal, and cervical cancers) as well as oropharyngeal cancers [ 4 ]. To date, about 200 genotypes of HPV have been identified, with approximately 40 of those infecting the genital tract [ 2 ]. Low-risk (LR) HPV types encompass a range of viral strains, namely, types 6, 11, 42, 43, 42, and 44.…”

Section: Introductionmentioning

confidence: 99%

“…is one of the sexually transmitted infectious agents and is a part of the human commensal flora, causing superficial and systemic infections. It has been suggested that these microorganisms alter the inflamed cervical epithelium, which increases the chance of HPV infection by enabling the virus to enter the basal cells of the epithelium [ 2 , 3 ]. Despite these hypothetical possibilities, it is currently unclear how HPV and Candida spp.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Candida albicans in High-Risk Human Papillomavirus-Positive Women: A Study in Diyarbakır Province, Turkey

Oktay Gultekin,

Can

2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

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The human papillomavirus (HPV) is a significant public health concern due to its association with the development of cervical cancer. Although inflammation caused by Candida spp. has been shown to facilitate oncogenesis, the interactions between HPV and Candida spp. remain unclear. This study aimed to determine the prevalence and genotype distribution of HR-HPV infection HR-HPV-positiveCandida albicans in HR-HPV-positive individuals in Diyarbakır province in Turkey. Cervical samples were taken from 350 participants aged 20–69 years who applied to Diyarbakır Gazi Yaşargil Training and Research Hospital, Gynecology and Obstetrics Clinic. For detection of HPV presence and HR-HPV genotyping, PCR/direct cycle sequencing was used. E6/E7 mRNA expression of HPV-16, -18, -31, -33, and -45 was determined by type-specific real-time NASBA assay (NucliSENS EasyQ(®)HPV v1.1). The presence of Candida albicans in cervical specimens of HR-HPV-positive women was investigated by RAPD-PCR and culture methods. Results. Of the 350 women who participated in the study, 24% were HPV positive and 10.5% were found to be HR-HPV positive. HR-HPV positivity was most frequently detected in the age range of 40–49 years. Among HR-HPV-positive women, C. albicans was found in 59.4%. Conclusion. The most frequent HR-HPV genotype was HPV16, followed by HPV31. Of women who tested positive for HR-HPV, C. albicans was discovered in 59.4%. C. albicans infection may occur when the immune system is weakened or the balance of the vaginal flora is disturbed, increasing tissue damage in the vaginal area and the risk of carcinogenesis of HR-HPV. Therefore, knowing the presence of Candida infection in HR-HPV-positive women is essential to plan the treatment and prevent the risk of secondary disease.

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Genotype Distribution and Prevalence of High-Risk Human Papillomavirus Infection among Women in Samsun Province of Turkey

Cited by 5 publications

References 28 publications

Status and epidemiological characteristics of high-risk human papillomavirus infection in multiple centers in Shenyang

Status and epidemiological characteristics of high-risk human papillomavirus infection in multiple centers in Shenyang

Epidemiology and genotypes analysis of human papillomavirus infection in Beijing, China

Prevalence of Candida albicans in High-Risk Human Papillomavirus-Positive Women: A Study in Diyarbakır Province, Turkey

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