Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity.

Bi, Yunxia; Sunada, Hisakazu; Yonezawa, Yorinobu; Danjo, Kazumi; Otsuka, Akihiro; Iida, Kotaro

doi:10.1248/cpb.44.2121

Cited by 282 publications

(221 citation statements)

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“…All formulations were evaluated for pre compression parameters such as angle of repose, bulk density, tapped density, Carr's consolidation index, and Hausner's ratio as per the official methods (Bi Y, 1996). 10 10 10 10 10 10 10 Total weight of each tablet was 450 mg; % was mentioned on the basis of concentration of polymer in tablet.…”

Section: Pre Compression Parametersmentioning

confidence: 99%

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Formulation and evaluation of lamivudine sustained release tablet using okra mucilage

Palei¹,

Mamidi²,

Rajangam³

2016

J App Pharm Sci

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The present study was to extract the mucilage from the Okra plant (Abelmoschus esculentus) and to study the effect of mucilage concentration on in vitro release of Lamivudine from it's sustained release matrix tablets. Mucilage was extracted from the fruits of Abelmoschus esclentus using organic solvent Acetone. The extracted mucilage was subjected to various physiological properties for its suitability as an excipient in the preparation of tablet. Lamivudine sustained release tablets were prepared using different concentration of Okra mucilage as a sustained release matrix excipient. The formulated tablets were evaluated for post compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, and in vitro drug release studies. Stability studies of optimized formulation were carried out for three months. The results of in vitro release revealed that the release rate decreased with increase in the concentration of mucilage. The release kinetics indicated that the nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation and therefore followed non-fickian or anomalous release. No incompatibility was observed between the drug and excipients used in the formulation of matrix tablets. The Okra mucilage showed promising results in terms of sustaining the release behavior of Lamivudine from the matrix. The developed sustained release tablets of Lamivudine, with extension of release up to 12 hours, can overcome all the disadvantages of conventional Lamivudine tablets.

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Section: Pre Compression Parametersmentioning

confidence: 99%

“…The tablets were dedusted and weighed again. The percentage of weight loss was calculated using the following formula (Bi YX et al, 1996):…”

Section: Friability Testmentioning

confidence: 99%

Formulation and evaluation of lamivudine sustained release tablet using okra mucilage

Palei¹,

Mamidi²,

Rajangam³

2016

J App Pharm Sci

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“…Distilled water, used as a disintegration medium, was kept at 37 °C±0.5 °C. The time consumed by each FDT to disintegrate completely without any residue remaining was recorded [28][29][30][31][32].…”

Section: Disintegration Testmentioning

confidence: 99%

Formulation of Fast-Dissolving Tablets of Doxazosin Mesylate Drug by Direct Compression Method

et al. 2017

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Objective: The rationale of the current research work was to formulate and evaluate fast-dissolving tablets of doxazosin mesylate with minimum disintegration time and improved dissolution efficiency using solid dispersion method.Methods: Solid dispersions of doxazosin mesylate and polyethylene glycol 8000 in different ratios were prepared using the kneading method. The prepared solid dispersions were subjected to drug interaction and dissolution studies to select the effective solid dispersion for the formulation of fast-dissolving tablets. Fast dissolving tablets containing drug-polyethylene glycol 8000 solid dispersion (1:3) were prepared using various superdisintegrants such as crospovidone, croscarmellose sodium, mixture and coprocessed crospovidone and croscarmellose sodium in concentration range of 2% and 5% by direct compression technique. The prepared formulations (F1-F16) were evaluated for post compression parameters; hardness, thickness, friability, wetting time, disintegration time, and in-vitro drug release.Results: Drug doxazosin mesylate showed enhanced aqueous solubility of 13.3µg/ml in the presence of polyethylene glycol 8000. Differential scanning calorimetery and Fourier transform infrared spectroscopy studies confirmed no interaction between drug and polyethylene glycol 8000and, drug-polyethylene glycol 8000 solid dispersion showed cumulative drug release of 44.48% in 60 min. Formulated FDT of drugpolyethylene glycol 8000 solid dispersion, containing coprocessed mixture of crospovidone and croscarmellose sodium (5%) exhibited disintegration time of 14.5s with percentage cumulative release of 92.46% in 60 min. Conclusion:The work reasonably concludes that for the formulated doxazosin mesylate-fast dissolving tablets, disintegration time was effectively reduced by the presence of coprocessed mixture of crospovidone and croscarmellose sodium and dissolution efficiency was improved by preparation of solid dispersion with polyethylene glycol 8000.

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“…Excipients affect the behavior and effectiveness of the drug product more and more functionality and significantly. The variability of active compounds, excipients and process are obvious components for the product variability [4].…”

Section: Pharmaceutical Excipientsmentioning

confidence: 99%

Herbal excipients in Novel Drug Delivery Systems

Chavhan¹,

Shinde²,

Sapkal³

et al. 2017

IRJDPL

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Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfil specific functions and in some cases, they directly or indirectly influence the extent and/or rate of drug release and drug absorption. Recent trends towards use of plant based and natural products demand the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural materials have many advantages over synthetic ones as they are chemically inert, nontoxic, less expensive, biodegradable, improve the shelf life of product and widely available. This article gives an overview of natural excipients which are used in conventional dosage forms as well as novel drug delivery systems.

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Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity.

Cited by 282 publications

References 0 publications

Formulation and evaluation of lamivudine sustained release tablet using okra mucilage

Formulation and evaluation of lamivudine sustained release tablet using okra mucilage

Formulation of Fast-Dissolving Tablets of Doxazosin Mesylate Drug by Direct Compression Method

Herbal excipients in Novel Drug Delivery Systems

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