Formulation of Fast-Dissolving Tablets of Doxazosin Mesylate Drug by Direct Compression Method

Preethi, G. B.; Banerjee, Sayan; Shivakumar, H.N.; Kumar, Mukesh

doi:10.22159/ijap.2017v9i5.18168

Cited by 16 publications

(17 citation statements)

References 16 publications

(21 reference statements)

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“…Then, magnesium stearate and aerosil were added and mixed well [9,10]. All materials were directly compressible, so the uniformly mixed blend was compressed into tablets using 7 mm punches on a twelve station tablet punching machine (Remek Minipress) [11]. All formulations were evaluated for different pre-compression and post-compression parameters.…”

Section: Formulation Of Fdtmentioning

confidence: 99%

Preparation and Evaluation of Fast Dissolving Tablets of Pitavastatin by 32 Full Factorial Design

Nirmala¹,

Maruvajala²

2019

Int J App Pharm

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Objective:The objective of the present work was to prepare an optimized, fast dissolving tablet (FDT) of Pitavastatin to increase its dissolution by applying 3 2 full factorial design.Methods: Nine formulations (PF1 to PF9) with all possible combinations according to 3 2 full factorial design by selecting two factors i.e. concentration of super disintegrant, Indion414 (5-15%) (A) and sublimating agent, camphor (40-60%) (B) as independent variables at three levels of-1, 0 and 1. The effect of these two variables on three dependent parameters, water absorption ratio (Y1), disintegration time (Y2) and in vitro drug release (Y3) was studied. All the powder blends were evaluated for precompression parameters, and the tablets were prepared by direct compression method which were further evaluated for post-compression parameters. The effect of change in concentration of two selected factors on dependent parameters was studied through 3D surface response plots and polynomial equations using Design expert software version11. Optimized formula was obtained by desirability and overlay plots for which compatibility stability was assessed.Results: Precompression and post-compression parameters were satisfactorily within acceptable limits. Optimized formulation was prepared to prove the validity of the evolved mathematical model, which contained 6.75 mg of indion414(0.9) and 54 mg of camphor(0.9) with a disintegration time of 21 sec., water absorption ratio of 113 and 93% of drug release within 12 min. The compatibility between drugs and excipients was proved. The dissolution profiles of optimized formulation and commercially available conventional film-coated tablets of Pitavastatin were compared. Conclusion:The optimized formulation showed significantly (P>0.05) increased drug release compared to commercially available film-coated tablets. No changes in disintegration time, drug content and in in vitro drug release from optimized formulation on storage for 3months at 40 °C±2 °C/75% RH±5% RH were observed during stability studies which confirmed the stability of the optimized formulation.

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Section: Formulation Of Fdtmentioning

confidence: 99%

Preparation and Evaluation of Fast Dissolving Tablets of Pitavastatin by 32 Full Factorial Design

Nirmala¹,

Maruvajala²

2019

Int J App Pharm

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“…Coprocessed mixture played an important role in decreasing disintegration time and enhanced the drug release [27].…”

Section: Parfati Et Almentioning

confidence: 99%

The Effect of Coprocessed Superdisintegrants Ratio (Crospovidone-Sodium Starch Glycolate) to the Physicochemical Characteristics of Atenolol Orally Disintegrating Tablets

Parfati

Rani

Meilany

2018

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets. Methods:Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation). Results:The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p<0.05). Dissolution test showed that all the formulas met the specification of dissolution from atenolol tablet (not <85% of atenolol was dissolved in 30 min). Formula 1 showed the highest dissolution efficiency (92.91±0.11)% and area under the curve value (11149.13±13.15) compared to formula 2 and formula 3. Conclusion:The results from this study showed that coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio affect the physicochemical characteristics of atenolol orally disintegrating tablet. Based on pre-compression evaluation and post-compression evaluation, formula 1 was the best formula.

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“…was entirely sealed into aluminum pans and under nitrogen atmosphere was heated at constant temperature of 10°C/min [12].…”

Section: Sehgal Et Almentioning

confidence: 99%

Fabrication and Evaluation of Solid Dispersion Containing Glibenclamide

Sehgal

et al. 2018

Asian J Pharm Clin Res

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Objective:The aim of the present study was to increase the dissolution rate of glibenclamide (GLIB) by molecular dispersion of drug in the polymeric matrix of Pluronic F-127.Methods: GLIB-loaded solid dispersions were formulated by fusion method. The formulated solid dispersions were characterized for scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and evaluated for percentage yield, drug content, solubility, and in vitro dissolution profile, and stability studies were conducted as per International Conference on Harmonisation guidelines Q1A in stability chamber, both at intermediate and accelerated conditions. Results: Both XRD and DSC studies suggested that crystalline GLIB was converted to amorphous form after loading into carrier. SEM studies revealed that the prepared solid dispersions were in the form of irregular particles with the absence of crystalline material. Due to this conversion of crystalline to amorphous state, formulated solid dispersions had shown improved dissolution rate profile of GLIB and stability studies suggested that formulated solid dispersions showed no significant changes in appearance and also in drug content. Conclusion:Thus, from the obtained results, it can be concluded that dissolution profile of GLIB can be improved by formulating as solid dispersion.

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Formulation of Fast-Dissolving Tablets of Doxazosin Mesylate Drug by Direct Compression Method

Cited by 16 publications

References 16 publications

Preparation and Evaluation of Fast Dissolving Tablets of Pitavastatin by 32 Full Factorial Design

Preparation and Evaluation of Fast Dissolving Tablets of Pitavastatin by 32 Full Factorial Design

The Effect of Coprocessed Superdisintegrants Ratio (Crospovidone-Sodium Starch Glycolate) to the Physicochemical Characteristics of Atenolol Orally Disintegrating Tablets

Fabrication and Evaluation of Solid Dispersion Containing Glibenclamide

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