Formulation and evaluation of lamivudine sustained release tablet using okra mucilage

Abstract

The present study was to extract the mucilage from the Okra plant (Abelmoschus esculentus) and to study the effect of mucilage concentration on in vitro release of Lamivudine from it's sustained release matrix tablets. Mucilage was extracted from the fruits of Abelmoschus esclentus using organic solvent Acetone. The extracted mucilage was subjected to various physiological properties for its suitability as an excipient in the preparation of tablet. Lamivudine sustained release tablets were prepared using different concentration of Okra mucilage as a sustained release matrix excipient. The formulated tablets were evaluated for post compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, and in vitro drug release studies. Stability studies of optimized formulation were carried out for three months. The results of in vitro release revealed that the release rate decreased with increase in the concentration of mucilage. The release kinetics indicated that the nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation and therefore followed non-fickian or anomalous release. No incompatibility was observed between the drug and excipients used in the formulation of matrix tablets. The Okra mucilage showed promising results in terms of sustaining the release behavior of Lamivudine from the matrix. The developed sustained release tablets of Lamivudine, with extension of release up to 12 hours, can overcome all the disadvantages of conventional Lamivudine tablets.

Formulation and evaluation of functional attributes of low‐fat mozzarella cheese using okra mucilage as a fat replacer

“…The results of the current study show great compatibility with the results of a study performed in the past, that is, mucilage showed good solubility in warm water as compared to cold water, and is completely insoluble in organic solvents (Farooq et al, 2013). Moreover, 1% okra mucilage has a viscosity of 240 cP and was well compatible with previous findings of Palei et al (2016), which reported okra mucilage viscosity of 247.34 cP.…”

“…Moreover, 1% okra mucilage has a viscosity of 240 cP and was well compatible with previous findings of Palei et al . (2016), which reported okra mucilage viscosity of 247.34 cP.…”

Evaluation of mucilage and powder of Okra as bio-flocculant in water treatment

“…In Figure 5, the larger band in the region of 3600-3100 cm -1 with a sharp peak centered at 3271 cm -1 is characteristic O-H stretching vibration and hydrogen bond of the hydroxyl groups [17]. These groups serve as active sites for the attachment of colloidal particles and okra powder [2].…”

Okra (Abelmoschus esculentus L.) as a Potential Functional Food Source of Mucilage and Bioactive Compounds with Technological Applications and Health Benefits

“…Palei, Mamidi, and Rajangam [ 98 ] prepared lamivudine controlled release tablets using different concentrations of okra mucilage as an excipient and observed that the in vitro release decreased with the increasing mucilage concentration, thus confirming its ability to control the release of lamivudine from the matrix. Table 2 shows other applications of okra mucilage as an excipient in pharmaceutical preparations.…”