Prenatal cocaine exposure accelerates morphological changes and transient expression of tyrosine hydroxylase in the cochlea of developing rats

Trigueiros-Cunha, Nuno; Leão, Pedro; Renard, Nathalie; Tavares, M. A.; Eybalin, Michel

doi:10.1016/j.brainres.2006.02.066

Cited by 5 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with a growing body of results in the animal and human literatures showing that IUCE is associated with alterations in auditory processes [27,74,86,108,122,131,134]. Specifically, results of our covariate-controlled analyses show that IUCE is associated with mild compromises on two age-referenced indices of auditory processes assessed by the NEPSY at preadolescence: Auditory Attention and Narrative Memory .…”

Section: Discussionsupporting

confidence: 91%

“…In the animal literature, IUCE has been shown to accelerate aspects of the cochlear sensorineural maturation process, which may desynchronize development of the auditory pathway and lead to auditory dysfunction, and may in turn be associated with altered auditory brainstem response identified in experimental animals postnatally [134]. Similarly, using a protocol designed to capture primary features of human recreational cocaine usage, Mactutus et al showed that IUCE in rats was associated with persistent alterations in auditory information processing and with dysfunction in the central noradrenergic circuitry modulating these responses [86].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory

Rose-Jacobs

Martin

Cabral

et al. 2014

Neurotoxicology and Teratology

View full text Add to dashboard Cite

Neuropsychological processes such as attention and memory contribute to children's higher-level cognitive and language functioning and predict academic achievement. The goal of this analysis was to evaluate whether level of intrauterine cocaine exposure (IUCE) alters multiple aspects of preadolescents' neuropsychological functioning assessed using a single age-referenced instrument, the NEPSY: A Developmental Neuropsychological Assessment (NEPSY) [71], after controlling for relevant covariates. Participants included 137 term 9.5-year-old children from low-income urban backgrounds (51% male, 90% African American/Caribbean) from an ongoing prospective longitudinal study. Level of IUCE was assessed in the newborn period using infant meconium and maternal report. 52% of the children had IUCE (65% with lighter IUCE, and 35% with heavier IUCE), and 48% were unexposed. Infants with Fetal Alcohol Syndrome, HIV seropositivity, or intrauterine exposure to illicit substances other than cocaine and marijuana were excluded. At the 9.5-year follow-up visit, trained examiners masked to IUCE and background variables evaluated children's neuropsychological functioning using the NEPSY. The association between level of IUCE and NEPSY outcomes was evaluated in a series of linear regressions controlling for intrauterine exposure to other substances and relevant child, caregiver, and demographic variables. Results indicated that level of IUCE was associated with lower scores on the Auditory Attention and Narrative Memory tasks, both of which require auditory information processing and sustained attention for successful performance. However, results did not follow the expected ordinal, dose-dependent pattern. Children's neuropsychological test scores were also altered by a variety of other biological and psychosocial factors.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory

Rose-Jacobs

Martin

Cabral

et al. 2014

Neurotoxicology and Teratology

View full text Add to dashboard Cite

show abstract

“…Crianças expostas à cocaína durante o período pré-natal mostraram latências absolutas e interpicos prolongados referentes aos Potenciais Evocados Auditivos de Tronco Encefálico (PEATE), no primeiro ano de vida. Estas mesmas alterações eletrofisiológicas foram observadas em ratos, além do aumento dos limiares eletrofisiológicos (6)(7) . Estas alterações podem ser causadas por falhas na função dos neurotransmissores ou por imaturidade mielínica; a hipóxia também pode contribuir para este aumento das latências, uma vez que o tronco encefálico é particularmente sensível à privação de oxigênio (6) .…”

unclassified

Potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas

Nigri¹,

Samelli

Schochat

2009

Rev. soc. bras. fonoaudiol.

View full text Add to dashboard Cite

RESUMOObjetivo: Analisar os potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas, bem como levantar as possíveis queixas auditivas e de equilíbrio nesta população. Métodos: Foram avaliados 40 usuários de drogas (20 com uso há mais de cinco anos e 20 há menos de cinco anos) e 20 não usuários, do sexo masculino, com idades entre 19 e 46 anos, com limiares auditivos dentro da normalidade. Resultados: Não houve diferenças significativas dos potenciais evocados auditivos de tronco encefálico dos usuários de drogas quando comparados ao grupo controle. Conclusão: Os potenciais evocados auditivos de tronco encefálico dos usuários de drogas não diferiram significantemente do grupo controle. As queixas apresentadas pelos usuários de drogas foram hiperacusia, alucinação auditiva, zumbido e alteração de equilíbrio.Descritores: Audição; Potenciais evocados auditivos do tronco encefálico; Efeitos de drogas; Cocaína/efeitos adversos; Cocaína crack/efeitos adversos; Drogas ilícitas/efeitos adversos INTRODUÇÃO O consumo de substâncias psicoativas tem gerado, em todas as partes do mundo, problemas sociais e de saúde pública de grande importância, devido a sua crescente prevalência (1)(2)(3) . A cocaína é um alcalóide extraído da folha da Erythroxylon coca; pode ser encontrada em duas formas: sal de hidrocloreto e "base livre". A primeira forma pode ser utilizada por via oral, injetada ou inalada; já a "base livre" é a mistura da cocaína com a amônia e o bicarbonato de sódio, que é usada para fumar (crack), sendo considerada a forma mais potente da droga (4) . A cocaína, quando inalada, é absorvida rapidamente pe los vasos pulmonares e atinge a circulação cerebral em aproximadamente seis a oito segundos, produzindo intensa euforia. As maiores concentrações da droga são encontradas no cérebro, no baço, nos rins e no pulmão (4) . Pesquisas têm mostrado que a cocaína promove alterações degenerativas nos neurônios e células gliais, assim como modificações nas funções dos receptores, na produção e na liberação de alguns neurotransmissores. Contudo, os processos neuroquímicos e vasculares envolvidos nesta aparente neurotoxicidade não foram ainda esclarecidos totalmente (3) . O uso de drogas por mulheres grávidas é um assunto bem conhecido e estudado. Sabe-se que o uso de drogas materno tem efeito no desenvolvimento do cérebro fetal, podendo ocorrer de duas formas principais: nas primeiras 20 semanas de gestação, atuando sobre a citogênese e a migração celular; na segunda metade da gestação, atuando sobre o crescimento do cérebro e sua diferenciação. A cocaína tem livre acesso na barreira placentária e pode causar hipóxia fetal em virtude da vasoconstrição placentária. Além disso, estudos animais mostraram alterações na organização e migração de neurônios e células da glia (5) . A cocaína utilizada durante a gestação pode alterar também o sistema auditivo. Crianças expostas à cocaína durante o período pré-natal mostraram latências absolutas e interpicos prolongados referentes aos Potenciais Evocados ...

show abstract

“…In animals, PCE accelerated maturation of the cochlea in rat pups, which appeared to cause auditory dysfunction by desynchronizing the development of the auditory pathway (Trigueiros-Cunha, Leão, Renard, Tavares, & Eybalin, 2006). …”

Section: Review Of Language Findings By Age At Assessmentmentioning

confidence: 99%

Language Outcomes at 12 Years for Children Exposed Prenatally to Cocaine

Lewis

Minnes

Short

et al. 2013

J Speech Lang Hear Res

View full text Add to dashboard Cite

Purpose In this study, the authors aimed to examine the long-term effects of prenatal cocaine exposure (PCE) on the language development of 12-year-old children using a prospective design, controlling for confounding prenatal drug exposure and environmental factors. Method Children who were exposed to cocaine in utero (PCE; n = 183) and children who were not exposed to cocaine (i.e., no cocaine exposure [NCE]; n = 181) were followed prospectively from birth to 12 years of age and were compared on language subtests of the Test of Language Development—Intermediate, Third Edition (Hammill & Newcomer, 1997b), and phonological processing as measured by the Comprehensive Test of Phonological Processing (Wagner & Torgesen, 1999). The authors evaluated the relationship of PCE to language development through a multivariate analysis of covariance and regression analyses while controlling for confounders. Results Results show that PCE has small effects on specific aspects of language, including syntax and phonological processing. The caregiver variables of lower maternal vocabulary, more psychological symptoms, and a poorer home environment also had consistent effects on language and phonological processing scores. Conclusions These findings suggest that PCE continues to have small, subtle effects on specific aspects of language at age 12 years. Phonological processing skills were significantly related to the reading outcomes of letter–word identification, reading fluency, and reading comprehension, indicating that PCE also has small but lasting effects on the language skills that are related to later literacy skills.

show abstract

Prenatal cocaine exposure accelerates morphological changes and transient expression of tyrosine hydroxylase in the cochlea of developing rats

Cited by 5 publications

References 55 publications

Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory

Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory

Potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas

Language Outcomes at 12 Years for Children Exposed Prenatally to Cocaine

Contact Info

Product

Resources

About